DNA Virus Vectors for Vaccine Production in Plants: Spotlight on Geminiviruses
Plants represent a safe, efficacious and inexpensive production platform by which to provide vaccines and other therapeutic proteins to the world’s poor. Plant virus expression vector technology has rapidly become one of the most popular methods to express pharmaceutical proteins in plants. This rev...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2014-08-01
|
| Series: | Vaccines |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2076-393X/2/3/642 |
| _version_ | 1811278846057512960 |
|---|---|
| author | Kathleen L. Hefferon |
| author_facet | Kathleen L. Hefferon |
| author_sort | Kathleen L. Hefferon |
| collection | DOAJ |
| description | Plants represent a safe, efficacious and inexpensive production platform by which to provide vaccines and other therapeutic proteins to the world’s poor. Plant virus expression vector technology has rapidly become one of the most popular methods to express pharmaceutical proteins in plants. This review discusses several of the state-of-the-art plant expression systems based upon geminiviruses that have been engineered for vaccine production. An overview of the advantages of these small, single-stranded DNA viruses is provided and comparisons are made with other virus expression systems. Advances in the design of several different geminivirus vectors are presented in this review, and examples of vaccines and other biologics generated from each are described. |
| first_indexed | 2024-04-13T00:43:50Z |
| format | Article |
| id | doaj.art-e918675d9d3844299cdedbaa99d37d1c |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-04-13T00:43:50Z |
| publishDate | 2014-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-e918675d9d3844299cdedbaa99d37d1c2022-12-22T03:10:05ZengMDPI AGVaccines2076-393X2014-08-012364265310.3390/vaccines2030642vaccines2030642DNA Virus Vectors for Vaccine Production in Plants: Spotlight on GeminivirusesKathleen L. Hefferon0Cell and Systems Biology, University of Toronto, Toronto, Ontario M5S 2J7, CanadaPlants represent a safe, efficacious and inexpensive production platform by which to provide vaccines and other therapeutic proteins to the world’s poor. Plant virus expression vector technology has rapidly become one of the most popular methods to express pharmaceutical proteins in plants. This review discusses several of the state-of-the-art plant expression systems based upon geminiviruses that have been engineered for vaccine production. An overview of the advantages of these small, single-stranded DNA viruses is provided and comparisons are made with other virus expression systems. Advances in the design of several different geminivirus vectors are presented in this review, and examples of vaccines and other biologics generated from each are described.http://www.mdpi.com/2076-393X/2/3/642vaccinevirus expression vectorgeminivirusplant |
| spellingShingle | Kathleen L. Hefferon DNA Virus Vectors for Vaccine Production in Plants: Spotlight on Geminiviruses Vaccines vaccine virus expression vector geminivirus plant |
| title | DNA Virus Vectors for Vaccine Production in Plants: Spotlight on Geminiviruses |
| title_full | DNA Virus Vectors for Vaccine Production in Plants: Spotlight on Geminiviruses |
| title_fullStr | DNA Virus Vectors for Vaccine Production in Plants: Spotlight on Geminiviruses |
| title_full_unstemmed | DNA Virus Vectors for Vaccine Production in Plants: Spotlight on Geminiviruses |
| title_short | DNA Virus Vectors for Vaccine Production in Plants: Spotlight on Geminiviruses |
| title_sort | dna virus vectors for vaccine production in plants spotlight on geminiviruses |
| topic | vaccine virus expression vector geminivirus plant |
| url | http://www.mdpi.com/2076-393X/2/3/642 |
| work_keys_str_mv | AT kathleenlhefferon dnavirusvectorsforvaccineproductioninplantsspotlightongeminiviruses |