Evaluation of Relationship Between Uric Acid and CRP, RDW, and MPV as Cardiovascular Risk Factors in Patients with Hypertension
Objective:Many factors that are associated with both clinical outcomes and pathogenesis of disease in cases of essential hypertension have been reported. One of these is uric acid. In this study, we aimed to investigate the relationship between serum and spot urine uric acid levels and red blood cel...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2017-01-01
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| Series: | Bezmiâlem Science |
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http://bezmialemscience.org/archives/archive-detail/article-preview/evaluation-of-relationship-between-uric-acid-and-c/20310
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| author | Yasemin AKER KARAGÖZ İrfan ŞAHİN Ferdi KARAGÖZ Dede ŞİT |
| author_facet | Yasemin AKER KARAGÖZ İrfan ŞAHİN Ferdi KARAGÖZ Dede ŞİT |
| author_sort | Yasemin AKER KARAGÖZ |
| collection | DOAJ |
| description | Objective:Many factors that are associated with both clinical outcomes and pathogenesis of disease in cases of essential hypertension have been reported. One of these is uric acid. In this study, we aimed to investigate the relationship between serum and spot urine uric acid levels and red blood cell distribution width (RDW), mean platelet volume (MPV), and C-reactive protein (CRP) levels in patients with essential hypertension.Methods:Sixty-two patients with essential hypertension were enrolled in the study between January 01, 2013 and December 31, 2013. The presence of cardiovascular disease was assessed by echocardiography, coronary angiography, and stress test. The patients were divided into two groups according to the absence (group 1) or presence (group 2) of cardiovascular complications. Data were collected for serum and spot urine uric acid levels, serum CRP levels, MPV, and RDW and were compared between the two groups.Results:Cardiovascular complications were determined in 23 patients (37.1%). In groups 1 and 2, the CRP level was 4.89 and 3.64, RDW was 13.8 and 13.5, serum uric acid level was 5.57±1.23 and 5.33±0.8, spot urine uric acid level was 65.13±29.11 and 61.94±18.13, and MPV was 7.7 and 7.2, respectively. A significant difference was not found between the two groups in terms of serum and spot urine uric acid levels, serum CRP levels, MPV, and RDW (p>0.05). In group 2, there was a significant negative correlation between the glomerular filtration rate and RDW and between RDW and MPV and positive correlation between CRP levels and RDW (p<0.01, p <0.05, and p<0.05, respectively).Conclusions:Serum and spot urine uric acid levels, serum CRP levels, MPV, and RDW cannot predict the development of cardiovascular disease in patients with essential hypertension. |
| first_indexed | 2024-04-10T13:01:03Z |
| format | Article |
| id | doaj.art-e9196a1e41d14c97a95a8f462d066ca9 |
| institution | Directory Open Access Journal |
| issn | 2148-2373 2148-2373 |
| language | English |
| last_indexed | 2024-04-10T13:01:03Z |
| publishDate | 2017-01-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Bezmiâlem Science |
| spelling | doaj.art-e9196a1e41d14c97a95a8f462d066ca92023-02-15T16:13:12ZengGalenos Publishing HouseBezmiâlem Science2148-23732148-23732017-01-0151162110.14235/bs.2016.60013049054Evaluation of Relationship Between Uric Acid and CRP, RDW, and MPV as Cardiovascular Risk Factors in Patients with HypertensionYasemin AKER KARAGÖZ0İrfan ŞAHİN1Ferdi KARAGÖZ2Dede ŞİT3 Clinic of Family Practice, Söğüt State Hospital, Bilecik, Turkey Clinic of Internal Diseases - Nephrology, and Cardiology, Bağcılar Training and Research Hospital, İstanbul, Turkey Clinic of Internal Diseases, Bilecik State Hospital, Bilecik, Turkey Clinic of Internal Diseases - Nephrology, and Cardiology, Bağcılar Training and Research Hospital, İstanbul, Turkey Objective:Many factors that are associated with both clinical outcomes and pathogenesis of disease in cases of essential hypertension have been reported. One of these is uric acid. In this study, we aimed to investigate the relationship between serum and spot urine uric acid levels and red blood cell distribution width (RDW), mean platelet volume (MPV), and C-reactive protein (CRP) levels in patients with essential hypertension.Methods:Sixty-two patients with essential hypertension were enrolled in the study between January 01, 2013 and December 31, 2013. The presence of cardiovascular disease was assessed by echocardiography, coronary angiography, and stress test. The patients were divided into two groups according to the absence (group 1) or presence (group 2) of cardiovascular complications. Data were collected for serum and spot urine uric acid levels, serum CRP levels, MPV, and RDW and were compared between the two groups.Results:Cardiovascular complications were determined in 23 patients (37.1%). In groups 1 and 2, the CRP level was 4.89 and 3.64, RDW was 13.8 and 13.5, serum uric acid level was 5.57±1.23 and 5.33±0.8, spot urine uric acid level was 65.13±29.11 and 61.94±18.13, and MPV was 7.7 and 7.2, respectively. A significant difference was not found between the two groups in terms of serum and spot urine uric acid levels, serum CRP levels, MPV, and RDW (p>0.05). In group 2, there was a significant negative correlation between the glomerular filtration rate and RDW and between RDW and MPV and positive correlation between CRP levels and RDW (p<0.01, p <0.05, and p<0.05, respectively).Conclusions:Serum and spot urine uric acid levels, serum CRP levels, MPV, and RDW cannot predict the development of cardiovascular disease in patients with essential hypertension. http://bezmialemscience.org/archives/archive-detail/article-preview/evaluation-of-relationship-between-uric-acid-and-c/20310 Hypertensionuric acidCRPMPWRDW |
| spellingShingle | Yasemin AKER KARAGÖZ İrfan ŞAHİN Ferdi KARAGÖZ Dede ŞİT Evaluation of Relationship Between Uric Acid and CRP, RDW, and MPV as Cardiovascular Risk Factors in Patients with Hypertension Bezmiâlem Science Hypertension uric acid CRP MPW RDW |
| title | Evaluation of Relationship Between Uric Acid and CRP, RDW, and MPV as Cardiovascular Risk Factors in Patients with Hypertension |
| title_full | Evaluation of Relationship Between Uric Acid and CRP, RDW, and MPV as Cardiovascular Risk Factors in Patients with Hypertension |
| title_fullStr | Evaluation of Relationship Between Uric Acid and CRP, RDW, and MPV as Cardiovascular Risk Factors in Patients with Hypertension |
| title_full_unstemmed | Evaluation of Relationship Between Uric Acid and CRP, RDW, and MPV as Cardiovascular Risk Factors in Patients with Hypertension |
| title_short | Evaluation of Relationship Between Uric Acid and CRP, RDW, and MPV as Cardiovascular Risk Factors in Patients with Hypertension |
| title_sort | evaluation of relationship between uric acid and crp rdw and mpv as cardiovascular risk factors in patients with hypertension |
| topic | Hypertension uric acid CRP MPW RDW |
| url |
http://bezmialemscience.org/archives/archive-detail/article-preview/evaluation-of-relationship-between-uric-acid-and-c/20310
|
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