PRState: Incorporating genetic ancestry in prostate cancer risk scores for men of African ancestry

PRState: Incorporating genetic ancestry in prostate cancer risk scores for men of African ancestry

Abstract Background Prostate cancer (PrCa) is one of the most genetically driven solid cancers with heritability estimates as high as 57%. Men of African ancestry are at an increased risk of PrCa; however, current polygenic risk score (PRS) models are based on European ancestry groups and may not be...

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Bibliographic Details
Main Authors: Meghana S. Pagadala, Joshua A. Linscott, James V. Talwar, Tyler M. Seibert, Brent Rose, Julie Lynch, Matthew Panizzon, Richard Hauger, Moritz H. Hansen, Jesse D. Sammon, Matthew H. Hayn, Karim Kader, Hannah Carter, Stephen T. Ryan
Format: Article
Language:English
Published: BMC 2022-12-01
Series:BMC Cancer
Subjects:
Prostate Cancer
Prostate Cancer Risk
Single nucleotide polymorphism (SNP)
Ancestry
African
Polygenic Risk Score (PRS)
Online Access:https://doi.org/10.1186/s12885-022-10258-3

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