Repair of Hypoxanthine in DNA Revealed by DNA Glycosylases and Endonucleases From Hyperthermophilic Archaea

Repair of Hypoxanthine in DNA Revealed by DNA Glycosylases and Endonucleases From Hyperthermophilic Archaea

Since hyperthermophilic Archaea (HA) thrive in high-temperature environments, which accelerate the rates of deamination of base in DNA, their genomic stability is facing a severe challenge. Hypoxanthine (Hx) is one of the common deaminated bases in DNA. Generally, replication of Hx in DNA before rep...

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Bibliographic Details
Main Authors: Tan Lin, Likui Zhang, Mai Wu, Donghao Jiang, Zheng Li, Zhihui Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Microbiology
Subjects:
hyperthermophilic archaea
DNA glycosylase
endonuclease
hypoxanthine
base deamination
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2021.736915/full

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