The Cross Talk between Underlying Mechanisms of Multiple Sclerosis and Epilepsy May Provide New Insights for More Efficient Therapies
Despite the significant differences in pathological background of neurodegenerative diseases, epileptic seizures are a comorbidity in many disorders such as Huntington disease (HD), Alzheimer’s disease (AD), and multiple sclerosis (MS). Regarding the last one, specifically, it has been shown that th...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-10-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/14/10/1031 |
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| author | Atefeh Rayatpour Sahar Farhangi Ester Verdaguer Jordi Olloquequi Jesus Ureña Carme Auladell Mohammad Javan |
| author_facet | Atefeh Rayatpour Sahar Farhangi Ester Verdaguer Jordi Olloquequi Jesus Ureña Carme Auladell Mohammad Javan |
| author_sort | Atefeh Rayatpour |
| collection | DOAJ |
| description | Despite the significant differences in pathological background of neurodegenerative diseases, epileptic seizures are a comorbidity in many disorders such as Huntington disease (HD), Alzheimer’s disease (AD), and multiple sclerosis (MS). Regarding the last one, specifically, it has been shown that the risk of developing epilepsy is three to six times higher in patients with MS compared to the general population. In this context, understanding the pathological processes underlying this connection will allow for the targeting of the common and shared pathological pathways involved in both conditions, which may provide a new avenue in the management of neurological disorders. This review provides an outlook of what is known so far about the bidirectional association between epilepsy and MS. |
| first_indexed | 2024-03-10T06:17:43Z |
| format | Article |
| id | doaj.art-e91b56059eca49b1a05129bb8c9acd71 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T06:17:43Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-e91b56059eca49b1a05129bb8c9acd712023-11-22T19:36:23ZengMDPI AGPharmaceuticals1424-82472021-10-011410103110.3390/ph14101031The Cross Talk between Underlying Mechanisms of Multiple Sclerosis and Epilepsy May Provide New Insights for More Efficient TherapiesAtefeh Rayatpour0Sahar Farhangi1Ester Verdaguer2Jordi Olloquequi3Jesus Ureña4Carme Auladell5Mohammad Javan6Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran 14117-13116, IranDepartment of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran 14117-13116, IranDepartment of Cell Biology, Physiology and Immunology, Biology Faculty, Universitat de Barcelona, 08028 Barcelona, SpainLaboratory of Cellular and Molecular Pathology, Biomedical Sciences Institute, Health Sciences Faculty, Universidad Autónoma de Chile, Talca 3460000, ChileDepartment of Cell Biology, Physiology and Immunology, Biology Faculty, Universitat de Barcelona, 08028 Barcelona, SpainDepartment of Cell Biology, Physiology and Immunology, Biology Faculty, Universitat de Barcelona, 08028 Barcelona, SpainDepartment of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran 14117-13116, IranDespite the significant differences in pathological background of neurodegenerative diseases, epileptic seizures are a comorbidity in many disorders such as Huntington disease (HD), Alzheimer’s disease (AD), and multiple sclerosis (MS). Regarding the last one, specifically, it has been shown that the risk of developing epilepsy is three to six times higher in patients with MS compared to the general population. In this context, understanding the pathological processes underlying this connection will allow for the targeting of the common and shared pathological pathways involved in both conditions, which may provide a new avenue in the management of neurological disorders. This review provides an outlook of what is known so far about the bidirectional association between epilepsy and MS.https://www.mdpi.com/1424-8247/14/10/1031multiple sclerosisdemyelinationepilepsyseizureneurodegeneration |
| spellingShingle | Atefeh Rayatpour Sahar Farhangi Ester Verdaguer Jordi Olloquequi Jesus Ureña Carme Auladell Mohammad Javan The Cross Talk between Underlying Mechanisms of Multiple Sclerosis and Epilepsy May Provide New Insights for More Efficient Therapies Pharmaceuticals multiple sclerosis demyelination epilepsy seizure neurodegeneration |
| title | The Cross Talk between Underlying Mechanisms of Multiple Sclerosis and Epilepsy May Provide New Insights for More Efficient Therapies |
| title_full | The Cross Talk between Underlying Mechanisms of Multiple Sclerosis and Epilepsy May Provide New Insights for More Efficient Therapies |
| title_fullStr | The Cross Talk between Underlying Mechanisms of Multiple Sclerosis and Epilepsy May Provide New Insights for More Efficient Therapies |
| title_full_unstemmed | The Cross Talk between Underlying Mechanisms of Multiple Sclerosis and Epilepsy May Provide New Insights for More Efficient Therapies |
| title_short | The Cross Talk between Underlying Mechanisms of Multiple Sclerosis and Epilepsy May Provide New Insights for More Efficient Therapies |
| title_sort | cross talk between underlying mechanisms of multiple sclerosis and epilepsy may provide new insights for more efficient therapies |
| topic | multiple sclerosis demyelination epilepsy seizure neurodegeneration |
| url | https://www.mdpi.com/1424-8247/14/10/1031 |
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