Diagnostic performance of platelet count/spleen diameter ratio to detect esophageal varices in patients with cirrhosis
Introduction: The platelet count/spleen diameter (PC/SD) ratio is a noninvasive method for the diagnosis of esophageal varices (EV) used as an alternative to endoscopy in patients with cirrhosis. Objective: To evaluate the diagnostic performance of the PC/SD ratio (cut-off point <909) to detec...
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| Format: | Article |
| Language: | English |
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Universidad Nacional de Colombia
2021-05-01
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| Series: | Revista de la Facultad de Medicina |
| Subjects: | |
| Online Access: | https://revistas.unal.edu.co/index.php/revfacmed/article/view/78786 |
| _version_ | 1797824742814646272 |
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| author | Julián David Martínez-Marín Katherine Marrugo-Padilla Martín Alonso Garzón-Olarte |
| author_facet | Julián David Martínez-Marín Katherine Marrugo-Padilla Martín Alonso Garzón-Olarte |
| author_sort | Julián David Martínez-Marín |
| collection | DOAJ |
| description |
Introduction: The platelet count/spleen diameter (PC/SD) ratio is a noninvasive method for the diagnosis of esophageal varices (EV) used as an alternative to endoscopy in patients with cirrhosis.
Objective: To evaluate the diagnostic performance of the PC/SD ratio (cut-off point <909) to detect EV in patients with cirrhosis treated at a tertiary referral hospital in Bogotá D.C., Colombia.
Materials and methods: A prospective diagnostic test accuracy study was conducted in 66 patients with cirrhosis treated at the Hospital Universitario de La Samaritana between July and December 2018. A descriptive analysis of the data was performed. In addition, the diagnostic performance of the PC/SD ratio (cut-off point <909) for the detection of EV was compared with the findings reported in the esophagogastroduodenoscopy (gold standard), calculating its sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), positive likelihood ratio (LR+), and negative likelihood ratio (LR-). A significance level of p<0.05 was considered.
Results: The mean age of the participants was 65.5 years, 53.03% were female, and the most common causes of cirrhosis were alcohol consumption (40.90%) and autoimmune hepatitis (22.72%). EV was diagnosed in 48 patients (72.72%). The PC/SC ratio showed sensitivity of 60%, specificity of 78%, PPV of 0.88, NPV of 0.42, LR+ of 2.73, and LR- of 0.51.
Conclusion: The low sensitivity, specificity, and NPV found in the present study suggest that the PC/SD ratio (cut-off point <909) may not be a useful diagnostic test for detecting EV in patients with cirrhosis.
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| first_indexed | 2024-03-13T10:43:42Z |
| format | Article |
| id | doaj.art-e91fe410b34f46ae813d7f1043a7a68b |
| institution | Directory Open Access Journal |
| issn | 0120-0011 2357-3848 |
| language | English |
| last_indexed | 2024-03-13T10:43:42Z |
| publishDate | 2021-05-01 |
| publisher | Universidad Nacional de Colombia |
| record_format | Article |
| series | Revista de la Facultad de Medicina |
| spelling | doaj.art-e91fe410b34f46ae813d7f1043a7a68b2023-05-17T22:03:12ZengUniversidad Nacional de ColombiaRevista de la Facultad de Medicina0120-00112357-38482021-05-0169310.15446/revfacmed.v69n3.78786Diagnostic performance of platelet count/spleen diameter ratio to detect esophageal varices in patients with cirrhosisJulián David Martínez-Marín0Katherine Marrugo-Padilla1Martín Alonso Garzón-Olarte2Universidad Nacional de Colombia - Bogotá Campus - Faculty of Medicine - Department of Gastroenterology - Bogotá D.C. - Colombia. | Hospital Universitario de La Samaritana Empresa Social del Estado - Gastroenterology Service - Bogotá D.C. - Colombia.Hospital Universitario de La Samaritana Empresa Social del Estado - Gastroenterology Service - Bogotá, D.C. - Colombia. | Universidad del Rosario - School of Health Sciences - Department of Gastroenterology - Bogotá, D.C. - Colombia.Hospital Universitario de La Samaritana Empresa Social del Estado - Gastroenterology Service - Bogotá, D.C. - Colombia. | Universidad del Rosario - School of Health Sciences - Department of Gastroenterology - Bogotá, D.C. - Colombia. Introduction: The platelet count/spleen diameter (PC/SD) ratio is a noninvasive method for the diagnosis of esophageal varices (EV) used as an alternative to endoscopy in patients with cirrhosis. Objective: To evaluate the diagnostic performance of the PC/SD ratio (cut-off point <909) to detect EV in patients with cirrhosis treated at a tertiary referral hospital in Bogotá D.C., Colombia. Materials and methods: A prospective diagnostic test accuracy study was conducted in 66 patients with cirrhosis treated at the Hospital Universitario de La Samaritana between July and December 2018. A descriptive analysis of the data was performed. In addition, the diagnostic performance of the PC/SD ratio (cut-off point <909) for the detection of EV was compared with the findings reported in the esophagogastroduodenoscopy (gold standard), calculating its sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), positive likelihood ratio (LR+), and negative likelihood ratio (LR-). A significance level of p<0.05 was considered. Results: The mean age of the participants was 65.5 years, 53.03% were female, and the most common causes of cirrhosis were alcohol consumption (40.90%) and autoimmune hepatitis (22.72%). EV was diagnosed in 48 patients (72.72%). The PC/SC ratio showed sensitivity of 60%, specificity of 78%, PPV of 0.88, NPV of 0.42, LR+ of 2.73, and LR- of 0.51. Conclusion: The low sensitivity, specificity, and NPV found in the present study suggest that the PC/SD ratio (cut-off point <909) may not be a useful diagnostic test for detecting EV in patients with cirrhosis. https://revistas.unal.edu.co/index.php/revfacmed/article/view/78786Platelet CountEsophageal VaricesLiver Cirrhosis |
| spellingShingle | Julián David Martínez-Marín Katherine Marrugo-Padilla Martín Alonso Garzón-Olarte Diagnostic performance of platelet count/spleen diameter ratio to detect esophageal varices in patients with cirrhosis Revista de la Facultad de Medicina Platelet Count Esophageal Varices Liver Cirrhosis |
| title | Diagnostic performance of platelet count/spleen diameter ratio to detect esophageal varices in patients with cirrhosis |
| title_full | Diagnostic performance of platelet count/spleen diameter ratio to detect esophageal varices in patients with cirrhosis |
| title_fullStr | Diagnostic performance of platelet count/spleen diameter ratio to detect esophageal varices in patients with cirrhosis |
| title_full_unstemmed | Diagnostic performance of platelet count/spleen diameter ratio to detect esophageal varices in patients with cirrhosis |
| title_short | Diagnostic performance of platelet count/spleen diameter ratio to detect esophageal varices in patients with cirrhosis |
| title_sort | diagnostic performance of platelet count spleen diameter ratio to detect esophageal varices in patients with cirrhosis |
| topic | Platelet Count Esophageal Varices Liver Cirrhosis |
| url | https://revistas.unal.edu.co/index.php/revfacmed/article/view/78786 |
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