Correlation between ketones and mental fatigue in high fat‐induced obese and non‐obese rats
Abstract Obesity, often caused by a diet high in calories and low physical activity, may induce physical fatigue, as experienced via decreased locomotor activity and mental fatigue such as impaired cognition. This study aims to evaluate glucose and ketone levels secondary to high‐fat diet (HFD) expo...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-07-01
|
| Series: | Physiological Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.14814/phy2.14930 |
| _version_ | 1818437766247088128 |
|---|---|
| author | Paige Niepoetter Carrie Butts‐Wilmsmeyer Sepideh Kaviani Coral Viernow Hannah Ruholl Chaya Gopalan |
| author_facet | Paige Niepoetter Carrie Butts‐Wilmsmeyer Sepideh Kaviani Coral Viernow Hannah Ruholl Chaya Gopalan |
| author_sort | Paige Niepoetter |
| collection | DOAJ |
| description | Abstract Obesity, often caused by a diet high in calories and low physical activity, may induce physical fatigue, as experienced via decreased locomotor activity and mental fatigue such as impaired cognition. This study aims to evaluate glucose and ketone levels secondary to high‐fat diet (HFD) exposure and signs of physical and mental fatigue. Fifty‐four 7‐week‐old male Sprague Dawley rats (Rattus norvegicus) were assigned to either an HFD (n = 28) or a standard diet (SD; n = 26) for a 6‐week period during which body weight, blood glucose, and ketones were measured twice per week. An open field (OF) paradigm was used to measure locomotor activity, while novel object recognition (NOR) test was used as an indicator of cognition. Animals in the HFD group weighed more than SD rats (8.4 g; p < 0.05) starting at Day 11, blood glucose levels were higher in the HFD group versus SD rats (3.9 mg/dl; p < 0.05) beginning in Week 5, and ketones were lower for the HFD versus the SD group throughout the study (0.34 mmol/L on average; p < 0.05). Although there was no significant difference in locomotor activity between the HFD and SD groups (p = 0.12), regardless of diet, higher ketone levels were associated with increased NOR time and ratio between the familiar and novel objects (p < 0.01). Thus, this study provides evidence that an increased level of ketones is associated with greater cognitive performance and a lesser probability of experiencing mental fatigue. |
| first_indexed | 2024-12-14T17:29:53Z |
| format | Article |
| id | doaj.art-e91fee3db79049d7978fbf6ca6dd055b |
| institution | Directory Open Access Journal |
| issn | 2051-817X |
| language | English |
| last_indexed | 2024-12-14T17:29:53Z |
| publishDate | 2021-07-01 |
| publisher | Wiley |
| record_format | Article |
| series | Physiological Reports |
| spelling | doaj.art-e91fee3db79049d7978fbf6ca6dd055b2022-12-21T22:53:07ZengWileyPhysiological Reports2051-817X2021-07-01913n/an/a10.14814/phy2.14930Correlation between ketones and mental fatigue in high fat‐induced obese and non‐obese ratsPaige Niepoetter0Carrie Butts‐Wilmsmeyer1Sepideh Kaviani2Coral Viernow3Hannah Ruholl4Chaya Gopalan5Department of Nurse Anesthesia Southern Illinois University Edwardsville Edwardsville IL USADepartment of Biological Sciences Southern Illinois University Edwardsville Edwardsville IL USADepartment of Applied Health Southern Illinois University Edwardsville Edwardsville IL USADepartment of Applied Health Southern Illinois University Edwardsville Edwardsville IL USADepartment of Nurse Anesthesia Southern Illinois University Edwardsville Edwardsville IL USADepartment of Nurse Anesthesia Southern Illinois University Edwardsville Edwardsville IL USAAbstract Obesity, often caused by a diet high in calories and low physical activity, may induce physical fatigue, as experienced via decreased locomotor activity and mental fatigue such as impaired cognition. This study aims to evaluate glucose and ketone levels secondary to high‐fat diet (HFD) exposure and signs of physical and mental fatigue. Fifty‐four 7‐week‐old male Sprague Dawley rats (Rattus norvegicus) were assigned to either an HFD (n = 28) or a standard diet (SD; n = 26) for a 6‐week period during which body weight, blood glucose, and ketones were measured twice per week. An open field (OF) paradigm was used to measure locomotor activity, while novel object recognition (NOR) test was used as an indicator of cognition. Animals in the HFD group weighed more than SD rats (8.4 g; p < 0.05) starting at Day 11, blood glucose levels were higher in the HFD group versus SD rats (3.9 mg/dl; p < 0.05) beginning in Week 5, and ketones were lower for the HFD versus the SD group throughout the study (0.34 mmol/L on average; p < 0.05). Although there was no significant difference in locomotor activity between the HFD and SD groups (p = 0.12), regardless of diet, higher ketone levels were associated with increased NOR time and ratio between the familiar and novel objects (p < 0.01). Thus, this study provides evidence that an increased level of ketones is associated with greater cognitive performance and a lesser probability of experiencing mental fatigue.https://doi.org/10.14814/phy2.14930cognitionfatiguehigh‐fat dietobesitySprague Dawley rats |
| spellingShingle | Paige Niepoetter Carrie Butts‐Wilmsmeyer Sepideh Kaviani Coral Viernow Hannah Ruholl Chaya Gopalan Correlation between ketones and mental fatigue in high fat‐induced obese and non‐obese rats Physiological Reports cognition fatigue high‐fat diet obesity Sprague Dawley rats |
| title | Correlation between ketones and mental fatigue in high fat‐induced obese and non‐obese rats |
| title_full | Correlation between ketones and mental fatigue in high fat‐induced obese and non‐obese rats |
| title_fullStr | Correlation between ketones and mental fatigue in high fat‐induced obese and non‐obese rats |
| title_full_unstemmed | Correlation between ketones and mental fatigue in high fat‐induced obese and non‐obese rats |
| title_short | Correlation between ketones and mental fatigue in high fat‐induced obese and non‐obese rats |
| title_sort | correlation between ketones and mental fatigue in high fat induced obese and non obese rats |
| topic | cognition fatigue high‐fat diet obesity Sprague Dawley rats |
| url | https://doi.org/10.14814/phy2.14930 |
| work_keys_str_mv | AT paigeniepoetter correlationbetweenketonesandmentalfatigueinhighfatinducedobeseandnonobeserats AT carriebuttswilmsmeyer correlationbetweenketonesandmentalfatigueinhighfatinducedobeseandnonobeserats AT sepidehkaviani correlationbetweenketonesandmentalfatigueinhighfatinducedobeseandnonobeserats AT coralviernow correlationbetweenketonesandmentalfatigueinhighfatinducedobeseandnonobeserats AT hannahruholl correlationbetweenketonesandmentalfatigueinhighfatinducedobeseandnonobeserats AT chayagopalan correlationbetweenketonesandmentalfatigueinhighfatinducedobeseandnonobeserats |