Acetazolamide for the treatment of acute mountain sickness
INTRODUCTION Acute mountain sickness is the most prevalent illness related to acute exposure to high altitude, secondary to the hypobaric hypoxia effects in our body. Acetazolamide has been traditionally used for its prevention and treatment, however, there is still controversy regarding the degree...
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| Format: | Article |
| Language: | English |
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Medwave Estudios Limitada
2019-12-01
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| Series: | Medwave |
| Subjects: | |
| Online Access: | https://www.medwave.cl/link.cgi/English/Updates/Epistemonikos/7736.act |
| _version_ | 1831724734222434304 |
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| author | Luciano Tapia Sebastián Irarrázaval |
| author_facet | Luciano Tapia Sebastián Irarrázaval |
| author_sort | Luciano Tapia |
| collection | DOAJ |
| description | INTRODUCTION
Acute mountain sickness is the most prevalent illness related to acute exposure to high altitude, secondary to the hypobaric hypoxia effects in our body. Acetazolamide has been traditionally used for its prevention and treatment, however, there is still controversy regarding the degree of usefulness of this medication as monotherapy.
METHODS
We searched in Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE, EMBASE, Cochrane, among others. We extracted data from the systematic reviews, reanalyzed data of primary studies, conducted a meta-analysis and generated a summary of findings table using the GRADE approach.
RESULTS AND CONCLUSIONS
We identified a systematic review that included two primary studies, both corresponding to randomized trials. We conclude that it is not possible to establish clearly whether treatment with acetazolamide reduces the symptoms of acute mountain disease or increases the risk of adverse effects, because the certainty of the existing evidence has been evaluated as very low. |
| first_indexed | 2024-12-21T04:26:59Z |
| format | Article |
| id | doaj.art-e922e57bbea64659bc88bf5cd82657c4 |
| institution | Directory Open Access Journal |
| issn | 0717-6384 0717-6384 |
| language | English |
| last_indexed | 2024-12-21T04:26:59Z |
| publishDate | 2019-12-01 |
| publisher | Medwave Estudios Limitada |
| record_format | Article |
| series | Medwave |
| spelling | doaj.art-e922e57bbea64659bc88bf5cd82657c42022-12-21T19:16:02ZengMedwave Estudios LimitadaMedwave0717-63840717-63842019-12-011911e7736e773610.5867/medwave.2019.11.7736Acetazolamide for the treatment of acute mountain sicknessLuciano Tapia0Sebastián Irarrázaval1Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile; Proyecto Epistemonikos, Santiago, ChileProyecto Epistemonikos, Santiago, Chile; Departamento de Traumatología, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago, ChileINTRODUCTION Acute mountain sickness is the most prevalent illness related to acute exposure to high altitude, secondary to the hypobaric hypoxia effects in our body. Acetazolamide has been traditionally used for its prevention and treatment, however, there is still controversy regarding the degree of usefulness of this medication as monotherapy. METHODS We searched in Epistemonikos, the largest database of systematic reviews in health, which is maintained by screening multiple information sources, including MEDLINE, EMBASE, Cochrane, among others. We extracted data from the systematic reviews, reanalyzed data of primary studies, conducted a meta-analysis and generated a summary of findings table using the GRADE approach. RESULTS AND CONCLUSIONS We identified a systematic review that included two primary studies, both corresponding to randomized trials. We conclude that it is not possible to establish clearly whether treatment with acetazolamide reduces the symptoms of acute mountain disease or increases the risk of adverse effects, because the certainty of the existing evidence has been evaluated as very low.https://www.medwave.cl/link.cgi/English/Updates/Epistemonikos/7736.actaltitudeacute mountain sicknessacetazolamideepistemonikosgrade |
| spellingShingle | Luciano Tapia Sebastián Irarrázaval Acetazolamide for the treatment of acute mountain sickness Medwave altitude acute mountain sickness acetazolamide epistemonikos grade |
| title | Acetazolamide for the treatment of acute mountain sickness |
| title_full | Acetazolamide for the treatment of acute mountain sickness |
| title_fullStr | Acetazolamide for the treatment of acute mountain sickness |
| title_full_unstemmed | Acetazolamide for the treatment of acute mountain sickness |
| title_short | Acetazolamide for the treatment of acute mountain sickness |
| title_sort | acetazolamide for the treatment of acute mountain sickness |
| topic | altitude acute mountain sickness acetazolamide epistemonikos grade |
| url | https://www.medwave.cl/link.cgi/English/Updates/Epistemonikos/7736.act |
| work_keys_str_mv | AT lucianotapia acetazolamideforthetreatmentofacutemountainsickness AT sebastianirarrazaval acetazolamideforthetreatmentofacutemountainsickness |