Comparison of Different Antibiotic Regimes for Preventive Tooth Extractions in Patients with Antiresorptive Intake—A Retrospective Cohort Study
In the present study, the impacts on success rates between three different antibiotic regimes in patients receiving preventive tooth extraction during/after antiresorptive treatment were compared. For the retrospective analysis, we enrolled patients who had undergone tooth extraction from 2009 to 20...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/12/6/997 |
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| author | Oliver Ristow Thomas Rückschloß Gregor Schnug Julius Moratin Moritz Bleymehl Sven Zittel Maximilian Pilz Caroline Sekundo Christian Mertens Michael Engel Jürgen Hoffmann Maximilian Smielowski |
| author_facet | Oliver Ristow Thomas Rückschloß Gregor Schnug Julius Moratin Moritz Bleymehl Sven Zittel Maximilian Pilz Caroline Sekundo Christian Mertens Michael Engel Jürgen Hoffmann Maximilian Smielowski |
| author_sort | Oliver Ristow |
| collection | DOAJ |
| description | In the present study, the impacts on success rates between three different antibiotic regimes in patients receiving preventive tooth extraction during/after antiresorptive treatment were compared. For the retrospective analysis, we enrolled patients who had undergone tooth extraction from 2009 to 2019 according to the specified preventive conditions under antiresorptive therapy. Three antibiotic regimens were distinguished: (Group 1) intravenous for 7 days, (Group 2) oral for 14 days, and (Group 3) oral for 7 days of application. The primary endpoint was the occurrence of medication-related osteonecrosis of the jaw at 12 weeks after surgery. A total of 760 patients and 1143 extraction regions were evaluated (Group 1 <i>n</i> = 719; Group 2 <i>n</i> = 126; Group 3 <i>n</i> = 298). The primary endpoint showed no significant difference in the development of medication-related osteonecrosis of the jaw between the groups studied (Group 1 <i>n</i> = 50/669 (7%); Group 2 <i>n</i> = 9/117 (7%); Group 3 <i>n</i> = 17/281 (6%); <i>p</i> = 0.746). Overall, the success rate was 93% after intervention when preventive measures were followed. With the same success rate, a reduced, oral administration of antibiotics seems to be sufficient regarding the possible spectrum of side effects, the development of resistance and the health economic point of view. |
| first_indexed | 2024-03-11T02:51:14Z |
| format | Article |
| id | doaj.art-e923ffaf46ec497fbf8cd5a41760b895 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-11T02:51:14Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-e923ffaf46ec497fbf8cd5a41760b8952023-11-18T09:00:36ZengMDPI AGAntibiotics2079-63822023-06-0112699710.3390/antibiotics12060997Comparison of Different Antibiotic Regimes for Preventive Tooth Extractions in Patients with Antiresorptive Intake—A Retrospective Cohort StudyOliver Ristow0Thomas Rückschloß1Gregor Schnug2Julius Moratin3Moritz Bleymehl4Sven Zittel5Maximilian Pilz6Caroline Sekundo7Christian Mertens8Michael Engel9Jürgen Hoffmann10Maximilian Smielowski11Department of Oral and Maxillofacial Surgery, University of Heidelberg, Im Neuenheimer Feld 400, D-69120 Heidelberg, GermanyDepartment of Oral and Maxillofacial Surgery, University of Heidelberg, Im Neuenheimer Feld 400, D-69120 Heidelberg, GermanyDepartment of Oral and Maxillofacial Surgery, University of Heidelberg, Im Neuenheimer Feld 400, D-69120 Heidelberg, GermanyDepartment of Oral and Maxillofacial Surgery, University of Heidelberg, Im Neuenheimer Feld 400, D-69120 Heidelberg, GermanyDepartment of Oral and Maxillofacial Surgery, University of Heidelberg, Im Neuenheimer Feld 400, D-69120 Heidelberg, GermanyDepartment of Oral and Maxillofacial Surgery, University of Heidelberg, Im Neuenheimer Feld 400, D-69120 Heidelberg, GermanyDepartment of Biometry, Institute of Medical Biometry, University of Heidelberg, Im Neuenheimer Feld 130.3, D-69120 Heidelberg, GermanyDepartment of Conservative Dentistry, University of Heidelberg, Im Neuenheimer Feld 400, D-69120 Heidelberg, GermanyDepartment of Oral and Maxillofacial Surgery, University of Heidelberg, Im Neuenheimer Feld 400, D-69120 Heidelberg, GermanyDepartment of Oral and Maxillofacial Surgery, University of Heidelberg, Im Neuenheimer Feld 400, D-69120 Heidelberg, GermanyDepartment of Oral and Maxillofacial Surgery, University of Heidelberg, Im Neuenheimer Feld 400, D-69120 Heidelberg, GermanyDepartment of Oral and Maxillofacial Surgery, University of Heidelberg, Im Neuenheimer Feld 400, D-69120 Heidelberg, GermanyIn the present study, the impacts on success rates between three different antibiotic regimes in patients receiving preventive tooth extraction during/after antiresorptive treatment were compared. For the retrospective analysis, we enrolled patients who had undergone tooth extraction from 2009 to 2019 according to the specified preventive conditions under antiresorptive therapy. Three antibiotic regimens were distinguished: (Group 1) intravenous for 7 days, (Group 2) oral for 14 days, and (Group 3) oral for 7 days of application. The primary endpoint was the occurrence of medication-related osteonecrosis of the jaw at 12 weeks after surgery. A total of 760 patients and 1143 extraction regions were evaluated (Group 1 <i>n</i> = 719; Group 2 <i>n</i> = 126; Group 3 <i>n</i> = 298). The primary endpoint showed no significant difference in the development of medication-related osteonecrosis of the jaw between the groups studied (Group 1 <i>n</i> = 50/669 (7%); Group 2 <i>n</i> = 9/117 (7%); Group 3 <i>n</i> = 17/281 (6%); <i>p</i> = 0.746). Overall, the success rate was 93% after intervention when preventive measures were followed. With the same success rate, a reduced, oral administration of antibiotics seems to be sufficient regarding the possible spectrum of side effects, the development of resistance and the health economic point of view.https://www.mdpi.com/2079-6382/12/6/997MRONJBRONJpreventionrisk reductiontooth extractionantibiotics |
| spellingShingle | Oliver Ristow Thomas Rückschloß Gregor Schnug Julius Moratin Moritz Bleymehl Sven Zittel Maximilian Pilz Caroline Sekundo Christian Mertens Michael Engel Jürgen Hoffmann Maximilian Smielowski Comparison of Different Antibiotic Regimes for Preventive Tooth Extractions in Patients with Antiresorptive Intake—A Retrospective Cohort Study Antibiotics MRONJ BRONJ prevention risk reduction tooth extraction antibiotics |
| title | Comparison of Different Antibiotic Regimes for Preventive Tooth Extractions in Patients with Antiresorptive Intake—A Retrospective Cohort Study |
| title_full | Comparison of Different Antibiotic Regimes for Preventive Tooth Extractions in Patients with Antiresorptive Intake—A Retrospective Cohort Study |
| title_fullStr | Comparison of Different Antibiotic Regimes for Preventive Tooth Extractions in Patients with Antiresorptive Intake—A Retrospective Cohort Study |
| title_full_unstemmed | Comparison of Different Antibiotic Regimes for Preventive Tooth Extractions in Patients with Antiresorptive Intake—A Retrospective Cohort Study |
| title_short | Comparison of Different Antibiotic Regimes for Preventive Tooth Extractions in Patients with Antiresorptive Intake—A Retrospective Cohort Study |
| title_sort | comparison of different antibiotic regimes for preventive tooth extractions in patients with antiresorptive intake a retrospective cohort study |
| topic | MRONJ BRONJ prevention risk reduction tooth extraction antibiotics |
| url | https://www.mdpi.com/2079-6382/12/6/997 |
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