Pharmacological Features of 18β-Glycyrrhetinic Acid: A Pentacyclic Triterpenoid of Therapeutic Potential
<i>Glycyrrhiza glabra</i> L. (belonging to the family Leguminosae), commonly known as Licorice, is a popular medicinal plant that has been used in traditional medicine worldwide for its ethnopharmacological efficacy in treating several ailments. Natural herbal substances with strong biol...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Plants |
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| Online Access: | https://www.mdpi.com/2223-7747/12/5/1086 |
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| author | Pottathil Shinu Girdhari Lal Gupta Manu Sharma Shahzad Khan Manoj Goyal Anroop B. Nair Manish Kumar Wafaa E. Soliman Aminur Rahman Mahesh Attimarad Katharigatta N. Venugopala Abdullah Abdulhamid Ahmed Altaweel |
| author_facet | Pottathil Shinu Girdhari Lal Gupta Manu Sharma Shahzad Khan Manoj Goyal Anroop B. Nair Manish Kumar Wafaa E. Soliman Aminur Rahman Mahesh Attimarad Katharigatta N. Venugopala Abdullah Abdulhamid Ahmed Altaweel |
| author_sort | Pottathil Shinu |
| collection | DOAJ |
| description | <i>Glycyrrhiza glabra</i> L. (belonging to the family Leguminosae), commonly known as Licorice, is a popular medicinal plant that has been used in traditional medicine worldwide for its ethnopharmacological efficacy in treating several ailments. Natural herbal substances with strong biological activity have recently received much attention. The main metabolite of glycyrrhizic acid is 18β-glycyrrhetinic acid (18βGA), a pentacyclic triterpene. A major active plant component derived from licorice root, 18βGA has sparked a lot of attention due to its pharmacological properties. The current review thoroughly examines the literature on 18βGA, a major active plant component obtained from <i>Glycyrrhiza glabra</i> L. The current work provides insight into the pharmacological activities of 18βGA and the potential mechanisms of action involved. The plant contains a variety of phytoconstituents such as 18βGA, which has a variety of biological effects including antiasthmatic, hepatoprotective, anticancer, nephroprotective, antidiabetic, antileishmanial, antiviral, antibacterial, antipsoriasis, antiosteoporosis, antiepileptic, antiarrhythmic, and anti-inflammatory, and is also useful in the management of pulmonary arterial hypertension, antipsychotic-induced hyperprolactinemia, and cerebral ischemia. This review examines research on the pharmacological characteristics of 18βGA throughout recent decades to demonstrate its therapeutic potential and any gaps that may exist, presenting possibilities for future drug research and development. |
| first_indexed | 2024-03-11T07:14:04Z |
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| id | doaj.art-e9285c43f43f4a8f95b4b78e53ecb6aa |
| institution | Directory Open Access Journal |
| issn | 2223-7747 |
| language | English |
| last_indexed | 2024-03-11T07:14:04Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Plants |
| spelling | doaj.art-e9285c43f43f4a8f95b4b78e53ecb6aa2023-11-17T08:23:55ZengMDPI AGPlants2223-77472023-03-01125108610.3390/plants12051086Pharmacological Features of 18β-Glycyrrhetinic Acid: A Pentacyclic Triterpenoid of Therapeutic PotentialPottathil Shinu0Girdhari Lal Gupta1Manu Sharma2Shahzad Khan3Manoj Goyal4Anroop B. Nair5Manish Kumar6Wafaa E. Soliman7Aminur Rahman8Mahesh Attimarad9Katharigatta N. Venugopala10Abdullah Abdulhamid Ahmed Altaweel11Department of Biomedical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi ArabiaDepartment of Pharmacology, School of Pharmacy and Technology Management, SVKM’s NMIMS University, Shirpur 425405, IndiaDepartment of Chemistry, National Forensic Sciences University Delhi Campus, New Delhi 110085, IndiaDepartment of Biomedical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi ArabiaDepartment of Anesthesia Technology, College of Applied Medical Sciences in Jubail, Imam Abdul Rahman Bin Faisal University, Jubail 35816, Saudi ArabiaDepartment of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi ArabiaDepartment of Pharmaceutics, M. M. College of Pharmacy, Maharishi Markandeshwar (Deemed to Be University), Ambala 133201, IndiaDepartment of Biomedical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi ArabiaDepartment of Biomedical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi ArabiaDepartment of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi ArabiaDepartment of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi ArabiaDepartment of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa 31982, Saudi Arabia<i>Glycyrrhiza glabra</i> L. (belonging to the family Leguminosae), commonly known as Licorice, is a popular medicinal plant that has been used in traditional medicine worldwide for its ethnopharmacological efficacy in treating several ailments. Natural herbal substances with strong biological activity have recently received much attention. The main metabolite of glycyrrhizic acid is 18β-glycyrrhetinic acid (18βGA), a pentacyclic triterpene. A major active plant component derived from licorice root, 18βGA has sparked a lot of attention due to its pharmacological properties. The current review thoroughly examines the literature on 18βGA, a major active plant component obtained from <i>Glycyrrhiza glabra</i> L. The current work provides insight into the pharmacological activities of 18βGA and the potential mechanisms of action involved. The plant contains a variety of phytoconstituents such as 18βGA, which has a variety of biological effects including antiasthmatic, hepatoprotective, anticancer, nephroprotective, antidiabetic, antileishmanial, antiviral, antibacterial, antipsoriasis, antiosteoporosis, antiepileptic, antiarrhythmic, and anti-inflammatory, and is also useful in the management of pulmonary arterial hypertension, antipsychotic-induced hyperprolactinemia, and cerebral ischemia. This review examines research on the pharmacological characteristics of 18βGA throughout recent decades to demonstrate its therapeutic potential and any gaps that may exist, presenting possibilities for future drug research and development.https://www.mdpi.com/2223-7747/12/5/108618β-glycyrrhetinic acidlicoricepharmacological actiontriterpenoid |
| spellingShingle | Pottathil Shinu Girdhari Lal Gupta Manu Sharma Shahzad Khan Manoj Goyal Anroop B. Nair Manish Kumar Wafaa E. Soliman Aminur Rahman Mahesh Attimarad Katharigatta N. Venugopala Abdullah Abdulhamid Ahmed Altaweel Pharmacological Features of 18β-Glycyrrhetinic Acid: A Pentacyclic Triterpenoid of Therapeutic Potential Plants 18β-glycyrrhetinic acid licorice pharmacological action triterpenoid |
| title | Pharmacological Features of 18β-Glycyrrhetinic Acid: A Pentacyclic Triterpenoid of Therapeutic Potential |
| title_full | Pharmacological Features of 18β-Glycyrrhetinic Acid: A Pentacyclic Triterpenoid of Therapeutic Potential |
| title_fullStr | Pharmacological Features of 18β-Glycyrrhetinic Acid: A Pentacyclic Triterpenoid of Therapeutic Potential |
| title_full_unstemmed | Pharmacological Features of 18β-Glycyrrhetinic Acid: A Pentacyclic Triterpenoid of Therapeutic Potential |
| title_short | Pharmacological Features of 18β-Glycyrrhetinic Acid: A Pentacyclic Triterpenoid of Therapeutic Potential |
| title_sort | pharmacological features of 18β glycyrrhetinic acid a pentacyclic triterpenoid of therapeutic potential |
| topic | 18β-glycyrrhetinic acid licorice pharmacological action triterpenoid |
| url | https://www.mdpi.com/2223-7747/12/5/1086 |
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