Is Associated with Bucillamine-Induced Proteinuria in Japanese Rheumatoid Arthritis Patients
Background Drug-induced proteinuria can occur in rheumatoid arthritis (RA) patients treated with d-penicillamine, gold salts, or bucillamine (Buc), and represents a drug hypersensitivity reaction. Striking associations of human leukocyte antigen (HLA) alleles with adverse reactions have recently bee...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2014-01-01
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| Series: | Biomarker Insights |
| Online Access: | https://doi.org/10.4137/BMI.S13654 |
| _version_ | 1818776844872187904 |
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| author | Hiroshi Furukawa Shomi Oka Kota Shimada Shoji Sugii Atsushi Hashimoto Akiko Komiya Naoshi Fukui Taiichiro Miyashita Kiyoshi Migita Akiko Suda Shouhei Nagaoka Naoyuki Tsuchiya Shigeto Tohma |
| author_facet | Hiroshi Furukawa Shomi Oka Kota Shimada Shoji Sugii Atsushi Hashimoto Akiko Komiya Naoshi Fukui Taiichiro Miyashita Kiyoshi Migita Akiko Suda Shouhei Nagaoka Naoyuki Tsuchiya Shigeto Tohma |
| author_sort | Hiroshi Furukawa |
| collection | DOAJ |
| description | Background Drug-induced proteinuria can occur in rheumatoid arthritis (RA) patients treated with d-penicillamine, gold salts, or bucillamine (Buc), and represents a drug hypersensitivity reaction. Striking associations of human leukocyte antigen (HLA) alleles with adverse reactions have recently been reported for many drugs. Methods We investigated the association of HLA class II with Buc-induced proteinuria (BI-Pro) in 485 Japanese RA patients treated with Buc, of whom 25 had developed BI-Pro. Results and Conclusion This preliminary study showed a highly significant association of DRB1*08:02 with BI-Pro ( P = 1.09 × 10 −6 , corrected P [ Pc ] = 1.96 × 10 −5 , odds ratio [OR] 25.17, 95% confidence interval [CI] 7.98-79.38). DQB1*04:02 was also significantly associated with increased risk of BI-Pro ( P = 2.44 × 10 −5 , Pc = 2.69 × 10 −4 , OR 10.35, 95%CI 3.99–26.83). These findings provide useful information for promoting personalized medicine for RA. |
| first_indexed | 2024-12-18T11:19:24Z |
| format | Article |
| id | doaj.art-e928ac3bdc0d41b69b10c100ab875f80 |
| institution | Directory Open Access Journal |
| issn | 1177-2719 |
| language | English |
| last_indexed | 2024-12-18T11:19:24Z |
| publishDate | 2014-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Biomarker Insights |
| spelling | doaj.art-e928ac3bdc0d41b69b10c100ab875f802022-12-21T21:09:51ZengSAGE PublishingBiomarker Insights1177-27192014-01-01910.4137/BMI.S13654Is Associated with Bucillamine-Induced Proteinuria in Japanese Rheumatoid Arthritis PatientsHiroshi Furukawa0Shomi Oka1Kota Shimada2Shoji Sugii3Atsushi Hashimoto4Akiko Komiya5Naoshi Fukui6Taiichiro Miyashita7Kiyoshi Migita8Akiko Suda9Shouhei Nagaoka10Naoyuki Tsuchiya11Shigeto Tohma12Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sakuradai, Minami-ku, Sagamihara, Japan.Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sakuradai, Minami-ku, Sagamihara, Japan.Department of Rheumatology, Sagamihara Hospital, National Hospital Organization, Sakuradai, Minami-ku, Sagamihara, Japan.Department of Rheumatology, Tokyo Metropolitan Tama Medical Center, Musashidai, Fuchu, Japan.Department of Rheumatology, Sagamihara Hospital, National Hospital Organization, Sakuradai, Minami-ku, Sagamihara, Japan.Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sakuradai, Minami-ku, Sagamihara, Japan.Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sakuradai, Minami-ku, Sagamihara, Japan.Nagasaki Medical Center, National Hospital Organization, Kubara, Omura, Japan.Nagasaki Medical Center, National Hospital Organization, Kubara, Omura, Japan.Department of Rheumatology, Yokohama Minami Kyosai Hospital, Rokuura Higashi, Kanazawa-ku, Yokohama, Japan.Department of Rheumatology, Yokohama Minami Kyosai Hospital, Rokuura Higashi, Kanazawa-ku, Yokohama, Japan.Molecular and Genetic Epidemiology Laboratory, Faculty of Medicine, University of Tsukuba, Tennodai, Tsukuba, Japan.Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sakuradai, Minami-ku, Sagamihara, Japan.Background Drug-induced proteinuria can occur in rheumatoid arthritis (RA) patients treated with d-penicillamine, gold salts, or bucillamine (Buc), and represents a drug hypersensitivity reaction. Striking associations of human leukocyte antigen (HLA) alleles with adverse reactions have recently been reported for many drugs. Methods We investigated the association of HLA class II with Buc-induced proteinuria (BI-Pro) in 485 Japanese RA patients treated with Buc, of whom 25 had developed BI-Pro. Results and Conclusion This preliminary study showed a highly significant association of DRB1*08:02 with BI-Pro ( P = 1.09 × 10 −6 , corrected P [ Pc ] = 1.96 × 10 −5 , odds ratio [OR] 25.17, 95% confidence interval [CI] 7.98-79.38). DQB1*04:02 was also significantly associated with increased risk of BI-Pro ( P = 2.44 × 10 −5 , Pc = 2.69 × 10 −4 , OR 10.35, 95%CI 3.99–26.83). These findings provide useful information for promoting personalized medicine for RA.https://doi.org/10.4137/BMI.S13654 |
| spellingShingle | Hiroshi Furukawa Shomi Oka Kota Shimada Shoji Sugii Atsushi Hashimoto Akiko Komiya Naoshi Fukui Taiichiro Miyashita Kiyoshi Migita Akiko Suda Shouhei Nagaoka Naoyuki Tsuchiya Shigeto Tohma Is Associated with Bucillamine-Induced Proteinuria in Japanese Rheumatoid Arthritis Patients Biomarker Insights |
| title | Is Associated with Bucillamine-Induced Proteinuria in Japanese Rheumatoid Arthritis Patients |
| title_full | Is Associated with Bucillamine-Induced Proteinuria in Japanese Rheumatoid Arthritis Patients |
| title_fullStr | Is Associated with Bucillamine-Induced Proteinuria in Japanese Rheumatoid Arthritis Patients |
| title_full_unstemmed | Is Associated with Bucillamine-Induced Proteinuria in Japanese Rheumatoid Arthritis Patients |
| title_short | Is Associated with Bucillamine-Induced Proteinuria in Japanese Rheumatoid Arthritis Patients |
| title_sort | is associated with bucillamine induced proteinuria in japanese rheumatoid arthritis patients |
| url | https://doi.org/10.4137/BMI.S13654 |
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