Clonal haematopoiesis - a novel entity that modifies pathological processes in elderly
Abstract Progress in the development of new sequencing techniques with wider accessibility and higher sensitivity of the protocol of deciphering genome particularities led to the discovery of a new phenomenon – clonal haematopoiesis. It is characterized by the presence in the bloodstream of elderly...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2023-09-01
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| Series: | Cell Death Discovery |
| Online Access: | https://doi.org/10.1038/s41420-023-01590-z |
| _version_ | 1797453913805291520 |
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| author | Ekaterina Belotserkovskaya Vasily Golotin Burhan Uyanik Oleg N. Demidov |
| author_facet | Ekaterina Belotserkovskaya Vasily Golotin Burhan Uyanik Oleg N. Demidov |
| author_sort | Ekaterina Belotserkovskaya |
| collection | DOAJ |
| description | Abstract Progress in the development of new sequencing techniques with wider accessibility and higher sensitivity of the protocol of deciphering genome particularities led to the discovery of a new phenomenon – clonal haematopoiesis. It is characterized by the presence in the bloodstream of elderly people a minor clonal population of cells with mutations in certain genes, but without any sign of disease related to the hematopoietic system. Here we will review this recent advancement in the field of clonal haematopoiesis and how it may affect the disease’s development in old age. |
| first_indexed | 2024-03-09T15:29:43Z |
| format | Article |
| id | doaj.art-e92960361f4c45cfacd91e55f4dfcd7f |
| institution | Directory Open Access Journal |
| issn | 2058-7716 |
| language | English |
| last_indexed | 2024-03-09T15:29:43Z |
| publishDate | 2023-09-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death Discovery |
| spelling | doaj.art-e92960361f4c45cfacd91e55f4dfcd7f2023-11-26T12:21:02ZengNature Publishing GroupCell Death Discovery2058-77162023-09-019111010.1038/s41420-023-01590-zClonal haematopoiesis - a novel entity that modifies pathological processes in elderlyEkaterina Belotserkovskaya0Vasily Golotin1Burhan Uyanik2Oleg N. Demidov3Institute of Cytology RAS, 4 Tikhoretskii prospectInstitute of Cytology RAS, 4 Tikhoretskii prospectINSERM UMR1231, Laboratory of Excellence LipSTIC and label Ligue Nationale contre le CancerInstitute of Cytology RAS, 4 Tikhoretskii prospectAbstract Progress in the development of new sequencing techniques with wider accessibility and higher sensitivity of the protocol of deciphering genome particularities led to the discovery of a new phenomenon – clonal haematopoiesis. It is characterized by the presence in the bloodstream of elderly people a minor clonal population of cells with mutations in certain genes, but without any sign of disease related to the hematopoietic system. Here we will review this recent advancement in the field of clonal haematopoiesis and how it may affect the disease’s development in old age.https://doi.org/10.1038/s41420-023-01590-z |
| spellingShingle | Ekaterina Belotserkovskaya Vasily Golotin Burhan Uyanik Oleg N. Demidov Clonal haematopoiesis - a novel entity that modifies pathological processes in elderly Cell Death Discovery |
| title | Clonal haematopoiesis - a novel entity that modifies pathological processes in elderly |
| title_full | Clonal haematopoiesis - a novel entity that modifies pathological processes in elderly |
| title_fullStr | Clonal haematopoiesis - a novel entity that modifies pathological processes in elderly |
| title_full_unstemmed | Clonal haematopoiesis - a novel entity that modifies pathological processes in elderly |
| title_short | Clonal haematopoiesis - a novel entity that modifies pathological processes in elderly |
| title_sort | clonal haematopoiesis a novel entity that modifies pathological processes in elderly |
| url | https://doi.org/10.1038/s41420-023-01590-z |
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