MiR-212 value in prognosis and diagnosis of cancer and its association with patient characteristics: a systematic review and meta-analysis
Abstract Background Delayed cancer diagnosis and inefficient cancer prognosis determination are problems faced in cancer diagnosis and treatment. MicroRNAs (miRs), especially miR-212, have shown a promise in cancer diagnosis and prognosis. Herein, we performed a systematic review and meta-analysis t...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-04-01
|
| Series: | Cancer Cell International |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12935-022-02584-0 |
| _version_ | 1818266863995453440 |
|---|---|
| author | Sara Raji Mehrdad Sahranavard Mahdi Mottaghi Amirhossein Sahebkar |
| author_facet | Sara Raji Mehrdad Sahranavard Mahdi Mottaghi Amirhossein Sahebkar |
| author_sort | Sara Raji |
| collection | DOAJ |
| description | Abstract Background Delayed cancer diagnosis and inefficient cancer prognosis determination are problems faced in cancer diagnosis and treatment. MicroRNAs (miRs), especially miR-212, have shown a promise in cancer diagnosis and prognosis. Herein, we performed a systematic review and meta-analysis to assess the prognostic and diagnostic value of miR-212 level in cancer and evaluated its association with patient characteristics. Methods A fully electronic literature search using related keywords was performed in PubMed, Scopus, Web of Science, Embase, and ScienceDirect databases by June 6, 2021, with no time or language restriction. Meta-analysis was performed to pool survival prognosis data using hazard ratio (HR), association using odds ratio (OR), and diagnostic data using sensitivity, specificity, and diagnostic odds ratio (DOR). Sub-group analysis and meta-regression were performed as appropriate. Results Results of 28 studies on 1880 patients showed a poor cancer prognosis with high levels of miR-212 in pancreatic ductal adenocarcinoma (PDAC, HR = 2.451 [1.447–4.149]), and a poor cancer prognosis with low levels of miR-212 in other cancers (HR = 2.514 [2.162–2.923]). Higher alpha-fetoprotein (AFP) level and Edmondson-Steiner grade were factors associated with miR-212 low level incidence. Diagnostic odds ratio 10.688 (3.644–31.348) and SROC AUC of 0.84 confirmed high diagnostic performance of miR-212. Conclusion Our systematic review and meta-analysis results confirm miR-212 high value in cancer prognosis and diagnosis. High level of miR-212 showed poor prognosis in PDAC and low level of miR-212 showed poor prognosis in other cancers. in conclusion, miR-212 could be a novel potential biomarker in cancer diagnosis and prognosis. |
| first_indexed | 2024-12-12T20:13:28Z |
| format | Article |
| id | doaj.art-e92a664f7d7f4079a840c97f314a5573 |
| institution | Directory Open Access Journal |
| issn | 1475-2867 |
| language | English |
| last_indexed | 2024-12-12T20:13:28Z |
| publishDate | 2022-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Cell International |
| spelling | doaj.art-e92a664f7d7f4079a840c97f314a55732022-12-22T00:13:28ZengBMCCancer Cell International1475-28672022-04-0122111410.1186/s12935-022-02584-0MiR-212 value in prognosis and diagnosis of cancer and its association with patient characteristics: a systematic review and meta-analysisSara Raji0Mehrdad Sahranavard1Mahdi Mottaghi2Amirhossein Sahebkar3Persian Cohort Research Center, Mashhad University of Medical SciencesSchool of Pharmacy, Mashhad University of Medical SciencesKidney Transplantation Complications Research Center, Mashhad University of Medical SciencesBiotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical SciencesAbstract Background Delayed cancer diagnosis and inefficient cancer prognosis determination are problems faced in cancer diagnosis and treatment. MicroRNAs (miRs), especially miR-212, have shown a promise in cancer diagnosis and prognosis. Herein, we performed a systematic review and meta-analysis to assess the prognostic and diagnostic value of miR-212 level in cancer and evaluated its association with patient characteristics. Methods A fully electronic literature search using related keywords was performed in PubMed, Scopus, Web of Science, Embase, and ScienceDirect databases by June 6, 2021, with no time or language restriction. Meta-analysis was performed to pool survival prognosis data using hazard ratio (HR), association using odds ratio (OR), and diagnostic data using sensitivity, specificity, and diagnostic odds ratio (DOR). Sub-group analysis and meta-regression were performed as appropriate. Results Results of 28 studies on 1880 patients showed a poor cancer prognosis with high levels of miR-212 in pancreatic ductal adenocarcinoma (PDAC, HR = 2.451 [1.447–4.149]), and a poor cancer prognosis with low levels of miR-212 in other cancers (HR = 2.514 [2.162–2.923]). Higher alpha-fetoprotein (AFP) level and Edmondson-Steiner grade were factors associated with miR-212 low level incidence. Diagnostic odds ratio 10.688 (3.644–31.348) and SROC AUC of 0.84 confirmed high diagnostic performance of miR-212. Conclusion Our systematic review and meta-analysis results confirm miR-212 high value in cancer prognosis and diagnosis. High level of miR-212 showed poor prognosis in PDAC and low level of miR-212 showed poor prognosis in other cancers. in conclusion, miR-212 could be a novel potential biomarker in cancer diagnosis and prognosis.https://doi.org/10.1186/s12935-022-02584-0miR-212miRNA-212microRNA-212PrognosisDiagnosisCancer |
| spellingShingle | Sara Raji Mehrdad Sahranavard Mahdi Mottaghi Amirhossein Sahebkar MiR-212 value in prognosis and diagnosis of cancer and its association with patient characteristics: a systematic review and meta-analysis Cancer Cell International miR-212 miRNA-212 microRNA-212 Prognosis Diagnosis Cancer |
| title | MiR-212 value in prognosis and diagnosis of cancer and its association with patient characteristics: a systematic review and meta-analysis |
| title_full | MiR-212 value in prognosis and diagnosis of cancer and its association with patient characteristics: a systematic review and meta-analysis |
| title_fullStr | MiR-212 value in prognosis and diagnosis of cancer and its association with patient characteristics: a systematic review and meta-analysis |
| title_full_unstemmed | MiR-212 value in prognosis and diagnosis of cancer and its association with patient characteristics: a systematic review and meta-analysis |
| title_short | MiR-212 value in prognosis and diagnosis of cancer and its association with patient characteristics: a systematic review and meta-analysis |
| title_sort | mir 212 value in prognosis and diagnosis of cancer and its association with patient characteristics a systematic review and meta analysis |
| topic | miR-212 miRNA-212 microRNA-212 Prognosis Diagnosis Cancer |
| url | https://doi.org/10.1186/s12935-022-02584-0 |
| work_keys_str_mv | AT sararaji mir212valueinprognosisanddiagnosisofcanceranditsassociationwithpatientcharacteristicsasystematicreviewandmetaanalysis AT mehrdadsahranavard mir212valueinprognosisanddiagnosisofcanceranditsassociationwithpatientcharacteristicsasystematicreviewandmetaanalysis AT mahdimottaghi mir212valueinprognosisanddiagnosisofcanceranditsassociationwithpatientcharacteristicsasystematicreviewandmetaanalysis AT amirhosseinsahebkar mir212valueinprognosisanddiagnosisofcanceranditsassociationwithpatientcharacteristicsasystematicreviewandmetaanalysis |