Red cell distribution width is increased in patients with ascending aortic dilatation
Objectives: The prognostic importance of red cell distribution width (RDW) and neutrophil/lymphocyte ratio (NLR) in cardiovascular diseases has been shown. Ascending aortic dilatation (AAD) is a common cardiovascular disease and is associated with aortic wall inflammation and cystic degeneration. I...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
KARE Publishing
2014-04-01
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| Series: | Türk Kardiyoloji Derneği Arşivi |
| Subjects: | |
| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tkd&un=TKDA-77508 |
| _version_ | 1797909371584249856 |
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| author | Barış Güngör Kazım Serhan Özcan Fatma Özpamuk Karadeniz Ahmet Ekmekçi Ahmet Taha Alpwe Damirbek Osmonov Mahmut Uluganyan Baran Karataş Ercan Toprak İzzet Celal Erdinler Osman Bolca |
| author_facet | Barış Güngör Kazım Serhan Özcan Fatma Özpamuk Karadeniz Ahmet Ekmekçi Ahmet Taha Alpwe Damirbek Osmonov Mahmut Uluganyan Baran Karataş Ercan Toprak İzzet Celal Erdinler Osman Bolca |
| author_sort | Barış Güngör |
| collection | DOAJ |
| description | Objectives: The prognostic importance of red cell distribution width (RDW) and neutrophil/lymphocyte ratio (NLR) in cardiovascular diseases has been shown. Ascending aortic dilatation (AAD) is a common cardiovascular disease and is associated with aortic wall inflammation and cystic degeneration. In this study, we aimed to investigate the relationship between serum levels of RDW, NLR and the presence of AAD.
Study design: Two-hundred consecutive patients with AAD diagnosed by transthoracic echocardiography were prospectively recruited and were compared to 170 age-gendermatched subjects with normal aortic diameters. Complete blood counts (CBCs) were analyzed for hemoglobin, RDW and NLR counts, as well as mean corpuscular volume (MCV). If possible, results of CBC tests within the previous two years were also included and the averages were used.
Results: RDW [median 13.9, interquartile range (IQR) 1.40 vs. median 13.3, IQR 1.05%, p=0.01], NLR (median 2.04, IQR 1.09 vs. median 1.78, IQR 0.90, p=0.01) and high-sensitive Creactive protein (hs-CRP) (median 0.60, IQR 0.80 vs. median 0.44, IQR 0.68 mg/L, p=0.01) levels were significantly higher in the AAD group compared to the control group. In univariate correlation analysis, ascending aortic diameters were correlated with RDW levels (r=0.31, p=0.01), NLR levels (r=0.15, p=0.01) and hs-CRP levels (r=0.12, p=0.03). In multivariate logistic regression analysis, increased levels of RDW and hs- CRP remained as the independent correlates of AAD in the study population. Receiver operating characteristic (ROC) curve analysis revealed that a RDW measurement higher than >13.8% predicted AAD with a sensitivity of 49.5% and a specificity of 82.8% (area under the curve [AUC] 0.681, p=0.01).
Conclusion: In patients with AAD, RDW and hs-CRP levels are increased, which may indicate the role of inflammation in the pathogenesis of AAD. |
| first_indexed | 2024-04-10T11:07:10Z |
| format | Article |
| id | doaj.art-e92d0eb89ee9450c95710e8cb4a9dd55 |
| institution | Directory Open Access Journal |
| issn | 1016-5169 |
| language | English |
| last_indexed | 2024-04-10T11:07:10Z |
| publishDate | 2014-04-01 |
| publisher | KARE Publishing |
| record_format | Article |
| series | Türk Kardiyoloji Derneği Arşivi |
| spelling | doaj.art-e92d0eb89ee9450c95710e8cb4a9dd552023-02-15T16:19:22ZengKARE PublishingTürk Kardiyoloji Derneği Arşivi1016-51692014-04-0142322723510.5543/tkda.2014.77508TKDA-77508Red cell distribution width is increased in patients with ascending aortic dilatationBarış Güngör0Kazım Serhan Özcan1Fatma Özpamuk Karadeniz2Ahmet Ekmekçi3Ahmet Taha Alpwe4Damirbek Osmonov5Mahmut Uluganyan6Baran Karataş7Ercan Toprak8İzzet Celal Erdinler9Osman Bolca10Department of Cardiovasculary Surgery, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Center, Training and Research Hospital, İstanbulDepartment of Cardiovasculary Surgery, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Center, Training and Research Hospital, İstanbulDepartment of Cardiovasculary Surgery, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Center, Training and Research Hospital, İstanbulDepartment of Cardiovasculary Surgery, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Center, Training and Research Hospital, İstanbulDepartment of Cardiovasculary Surgery, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Center, Training and Research Hospital, İstanbulDepartment of Cardiovasculary Surgery, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Center, Training and Research Hospital, İstanbulDepartment of Cardiovasculary Surgery, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Center, Training and Research Hospital, İstanbulDepartment of Cardiovasculary Surgery, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Center, Training and Research Hospital, İstanbulDepartment of Cardiovasculary Surgery, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Center, Training and Research Hospital, İstanbulDepartment of Cardiovasculary Surgery, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Center, Training and Research Hospital, İstanbulDepartment of Cardiovasculary Surgery, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Center, Training and Research Hospital, İstanbulObjectives: The prognostic importance of red cell distribution width (RDW) and neutrophil/lymphocyte ratio (NLR) in cardiovascular diseases has been shown. Ascending aortic dilatation (AAD) is a common cardiovascular disease and is associated with aortic wall inflammation and cystic degeneration. In this study, we aimed to investigate the relationship between serum levels of RDW, NLR and the presence of AAD. Study design: Two-hundred consecutive patients with AAD diagnosed by transthoracic echocardiography were prospectively recruited and were compared to 170 age-gendermatched subjects with normal aortic diameters. Complete blood counts (CBCs) were analyzed for hemoglobin, RDW and NLR counts, as well as mean corpuscular volume (MCV). If possible, results of CBC tests within the previous two years were also included and the averages were used. Results: RDW [median 13.9, interquartile range (IQR) 1.40 vs. median 13.3, IQR 1.05%, p=0.01], NLR (median 2.04, IQR 1.09 vs. median 1.78, IQR 0.90, p=0.01) and high-sensitive Creactive protein (hs-CRP) (median 0.60, IQR 0.80 vs. median 0.44, IQR 0.68 mg/L, p=0.01) levels were significantly higher in the AAD group compared to the control group. In univariate correlation analysis, ascending aortic diameters were correlated with RDW levels (r=0.31, p=0.01), NLR levels (r=0.15, p=0.01) and hs-CRP levels (r=0.12, p=0.03). In multivariate logistic regression analysis, increased levels of RDW and hs- CRP remained as the independent correlates of AAD in the study population. Receiver operating characteristic (ROC) curve analysis revealed that a RDW measurement higher than >13.8% predicted AAD with a sensitivity of 49.5% and a specificity of 82.8% (area under the curve [AUC] 0.681, p=0.01). Conclusion: In patients with AAD, RDW and hs-CRP levels are increased, which may indicate the role of inflammation in the pathogenesis of AAD.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tkd&un=TKDA-77508ascending aortic dilatationc-reactive protein/metabolism; echocardiography; erythrocyte indices; red cell distribution width; roc curve. |
| spellingShingle | Barış Güngör Kazım Serhan Özcan Fatma Özpamuk Karadeniz Ahmet Ekmekçi Ahmet Taha Alpwe Damirbek Osmonov Mahmut Uluganyan Baran Karataş Ercan Toprak İzzet Celal Erdinler Osman Bolca Red cell distribution width is increased in patients with ascending aortic dilatation Türk Kardiyoloji Derneği Arşivi ascending aortic dilatation c-reactive protein/metabolism; echocardiography; erythrocyte indices; red cell distribution width; roc curve. |
| title | Red cell distribution width is increased in patients with ascending aortic dilatation |
| title_full | Red cell distribution width is increased in patients with ascending aortic dilatation |
| title_fullStr | Red cell distribution width is increased in patients with ascending aortic dilatation |
| title_full_unstemmed | Red cell distribution width is increased in patients with ascending aortic dilatation |
| title_short | Red cell distribution width is increased in patients with ascending aortic dilatation |
| title_sort | red cell distribution width is increased in patients with ascending aortic dilatation |
| topic | ascending aortic dilatation c-reactive protein/metabolism; echocardiography; erythrocyte indices; red cell distribution width; roc curve. |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tkd&un=TKDA-77508 |
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