Assessment of salivary levels of 8-OHdG in patients with periodontitis and/or obesity
Background: Periodontitis is universally agreed to be an inflammatory disorder which arises as a consequence of periodontal pathogens interacting with the host’s immune response. A significant and crucial element in the onset and advancement of periodontitis is oxidative stress. 8-OHdG is a molecu...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
university of basrah
2023-12-01
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| Series: | Basrah Journal of Surgery |
| Subjects: | |
| Online Access: | https://bjsrg.uobasrah.edu.iq/article_181776.html |
| Summary: | Background: Periodontitis is universally agreed to be an inflammatory disorder which arises as a
consequence of periodontal pathogens interacting with the host’s immune response. A significant and
crucial element in the onset and advancement of periodontitis is oxidative stress. 8-OHdG is a molecule
that’s considered a significant biomarker of oxidative stress.
Aim of the study: Analyzing the salivary levels of 8-OHdG in patients with periodontitis/obesity in
comparison to healthy controls with analysis of its correlation with various clinical periodontal parameters.
Materials and methods: 110 subjects (30 obese, 30 periodontitis, 30 obese periodontitis and 20 healthy
subjects) took part in this study. Samples of saliva were acquired from all subjects before clinical
examination. Full periodontal examination was conducted for each participant which entailed plaque index
PLI, bleeding on probing BOP, probing pocket depth PPD and clinical attachment loss CAL. We assessed
obesity utilizing body mass index BMI.
Results: It was showed that periodontitis patients and obese patients had significantly elevated
concentrations of salivary 8-OHdG when compared with healthy subjects. Also these levels correlated
positively with CAL in obese periodontitis patients.
Conclusions: This study revealed an association between 8-OHdG and periodontitis which implies that this
biomarker serves a vital part in the periodontal disease process. Moreover, this study showed an association
between this biomarker and obesity measures, which suggests that periodontitis and obesity are
interconnected via oxidative stress. |
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| ISSN: | 1683-3589 2409-501X |