Recent Advances in Chitosan and its Derivatives in Cancer Treatment
Cancer has become a main public health issue globally. The conventional treatment measures for cancer include surgery, radiotherapy and chemotherapy. Among the various available treatment measures, chemotherapy is still one of the most important treatments for most cancer patients. However, chemothe...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-04-01
|
| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.888740/full |
| _version_ | 1811319070879907840 |
|---|---|
| author | Jingxian Ding Yonghong Guo |
| author_facet | Jingxian Ding Yonghong Guo |
| author_sort | Jingxian Ding |
| collection | DOAJ |
| description | Cancer has become a main public health issue globally. The conventional treatment measures for cancer include surgery, radiotherapy and chemotherapy. Among the various available treatment measures, chemotherapy is still one of the most important treatments for most cancer patients. However, chemotherapy for most cancers still faces many problems associated with a lot of adverse effects, which limit its therapeutic potency, low survival quality and discount cancer prognosis. In order to decrease these side effects and improve treatment effectiveness and patient’s compliance, more targeted treatments are needed. Sustainable and controlled deliveries of drugs with controllable toxicities are expected to address these hurdles. Chitosan is the second most abundant natural polysaccharide, which has excellent biocompatibility and notable antitumor activity. Its biodegradability, biocompatibility, biodistribution, nontoxicity and immunogenicity free have made chitosan become a widely used polymer in the pharmacology, especially in oncotherapy. Here, we make a brief review of the main achievements in chitosan and its derivatives in pharmacology with a special focus on their agents delivery applications, immunomodulation, signal pathway modulation and antitumor activity to highlight their role in cancer treatment. Despite a large number of successful studies, the commercialization of chitosan copolymers is still a big challenge. The further development of polymerization technology may satisfy the unmet medical needs. |
| first_indexed | 2024-04-13T12:35:52Z |
| format | Article |
| id | doaj.art-e9305404bc694925a780ea8b285922d8 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-13T12:35:52Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-e9305404bc694925a780ea8b285922d82022-12-22T02:46:40ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-04-011310.3389/fphar.2022.888740888740Recent Advances in Chitosan and its Derivatives in Cancer TreatmentJingxian Ding0Yonghong Guo1Department of Radiation Oncology, The Breast Cancer Institute, The Third Hospital of Nanchang, Nanchang, ChinaDepartment of Radiation Oncology, The Fourth Affiliated Hospital of Nanchang University, Nanchang, ChinaCancer has become a main public health issue globally. The conventional treatment measures for cancer include surgery, radiotherapy and chemotherapy. Among the various available treatment measures, chemotherapy is still one of the most important treatments for most cancer patients. However, chemotherapy for most cancers still faces many problems associated with a lot of adverse effects, which limit its therapeutic potency, low survival quality and discount cancer prognosis. In order to decrease these side effects and improve treatment effectiveness and patient’s compliance, more targeted treatments are needed. Sustainable and controlled deliveries of drugs with controllable toxicities are expected to address these hurdles. Chitosan is the second most abundant natural polysaccharide, which has excellent biocompatibility and notable antitumor activity. Its biodegradability, biocompatibility, biodistribution, nontoxicity and immunogenicity free have made chitosan become a widely used polymer in the pharmacology, especially in oncotherapy. Here, we make a brief review of the main achievements in chitosan and its derivatives in pharmacology with a special focus on their agents delivery applications, immunomodulation, signal pathway modulation and antitumor activity to highlight their role in cancer treatment. Despite a large number of successful studies, the commercialization of chitosan copolymers is still a big challenge. The further development of polymerization technology may satisfy the unmet medical needs.https://www.frontiersin.org/articles/10.3389/fphar.2022.888740/fullcancer treatmentanticancer drugsdrug delivery systemchitosanpolysaccharides |
| spellingShingle | Jingxian Ding Yonghong Guo Recent Advances in Chitosan and its Derivatives in Cancer Treatment Frontiers in Pharmacology cancer treatment anticancer drugs drug delivery system chitosan polysaccharides |
| title | Recent Advances in Chitosan and its Derivatives in Cancer Treatment |
| title_full | Recent Advances in Chitosan and its Derivatives in Cancer Treatment |
| title_fullStr | Recent Advances in Chitosan and its Derivatives in Cancer Treatment |
| title_full_unstemmed | Recent Advances in Chitosan and its Derivatives in Cancer Treatment |
| title_short | Recent Advances in Chitosan and its Derivatives in Cancer Treatment |
| title_sort | recent advances in chitosan and its derivatives in cancer treatment |
| topic | cancer treatment anticancer drugs drug delivery system chitosan polysaccharides |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.888740/full |
| work_keys_str_mv | AT jingxianding recentadvancesinchitosananditsderivativesincancertreatment AT yonghongguo recentadvancesinchitosananditsderivativesincancertreatment |