The role of YAP/TAZ activity in cancer metabolic reprogramming
Abstract In contrast to normal cells, which use the aerobic oxidation of glucose as their main energy production method, cancer cells prefer to use anaerobic glycolysis to maintain their growth and survival, even under normoxic conditions. Such tumor cell metabolic reprogramming is regulated by fact...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2018-09-01
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| Series: | Molecular Cancer |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12943-018-0882-1 |
| _version_ | 1811268990898536448 |
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| author | Xiaodong Zhang Haiying Zhao Yan Li Di Xia Liang Yang Yingbo Ma Hangyu Li |
| author_facet | Xiaodong Zhang Haiying Zhao Yan Li Di Xia Liang Yang Yingbo Ma Hangyu Li |
| author_sort | Xiaodong Zhang |
| collection | DOAJ |
| description | Abstract In contrast to normal cells, which use the aerobic oxidation of glucose as their main energy production method, cancer cells prefer to use anaerobic glycolysis to maintain their growth and survival, even under normoxic conditions. Such tumor cell metabolic reprogramming is regulated by factors such as hypoxia and the tumor microenvironment. In addition, dysregulation of certain signaling pathways also contributes to cancer metabolic reprogramming. Among them, the Hippo signaling pathway is a highly conserved tumor suppressor pathway. The core oncosuppressive kinase cascade of Hippo pathway inhibits the nuclear transcriptional co-activators YAP and TAZ, which are the downstream effectors of Hippo pathway and oncogenic factors in many solid cancers. YAP/TAZ function as key nodes of multiple signaling pathways and play multiple regulatory roles in cancer cells. However, their roles in cancer metabolic reprograming are less clear. In the present review, we examine progress in research into the regulatory mechanisms of YAP/TAZ on glucose metabolism, fatty acid metabolism, mevalonate metabolism, and glutamine metabolism in cancer cells. Determining the roles of YAP/TAZ in tumor energy metabolism, particularly in relation to the tumor microenvironment, will provide new strategies and targets for the selective therapy of metabolism-related cancers. |
| first_indexed | 2024-04-12T21:34:02Z |
| format | Article |
| id | doaj.art-e930f413c1db4037ba184f0a5f796985 |
| institution | Directory Open Access Journal |
| issn | 1476-4598 |
| language | English |
| last_indexed | 2024-04-12T21:34:02Z |
| publishDate | 2018-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Cancer |
| spelling | doaj.art-e930f413c1db4037ba184f0a5f7969852022-12-22T03:15:58ZengBMCMolecular Cancer1476-45982018-09-0117111010.1186/s12943-018-0882-1The role of YAP/TAZ activity in cancer metabolic reprogrammingXiaodong Zhang0Haiying Zhao1Yan Li2Di Xia3Liang Yang4Yingbo Ma5Hangyu Li6Department of General Surgery, The Fourth Affiliated Hospital of China Medical UniversityDepartment of General Surgery, The Fourth Affiliated Hospital of China Medical UniversityDepartment of General Surgery, The Fourth Affiliated Hospital of China Medical UniversityDepartment of Gynecology, Beijing Obstetrics and Gynecology Hospital, Capital Medical UniversityDepartment of General Surgery, The Fourth Affiliated Hospital of China Medical UniversityDepartment of General Surgery, The Fourth Affiliated Hospital of China Medical UniversityDepartment of General Surgery, The Fourth Affiliated Hospital of China Medical UniversityAbstract In contrast to normal cells, which use the aerobic oxidation of glucose as their main energy production method, cancer cells prefer to use anaerobic glycolysis to maintain their growth and survival, even under normoxic conditions. Such tumor cell metabolic reprogramming is regulated by factors such as hypoxia and the tumor microenvironment. In addition, dysregulation of certain signaling pathways also contributes to cancer metabolic reprogramming. Among them, the Hippo signaling pathway is a highly conserved tumor suppressor pathway. The core oncosuppressive kinase cascade of Hippo pathway inhibits the nuclear transcriptional co-activators YAP and TAZ, which are the downstream effectors of Hippo pathway and oncogenic factors in many solid cancers. YAP/TAZ function as key nodes of multiple signaling pathways and play multiple regulatory roles in cancer cells. However, their roles in cancer metabolic reprograming are less clear. In the present review, we examine progress in research into the regulatory mechanisms of YAP/TAZ on glucose metabolism, fatty acid metabolism, mevalonate metabolism, and glutamine metabolism in cancer cells. Determining the roles of YAP/TAZ in tumor energy metabolism, particularly in relation to the tumor microenvironment, will provide new strategies and targets for the selective therapy of metabolism-related cancers.http://link.springer.com/article/10.1186/s12943-018-0882-1YAP/TAZMetabolic reprogramingGlycolysisGluconeogenesisFatty acidsMevalonate |
| spellingShingle | Xiaodong Zhang Haiying Zhao Yan Li Di Xia Liang Yang Yingbo Ma Hangyu Li The role of YAP/TAZ activity in cancer metabolic reprogramming Molecular Cancer YAP/TAZ Metabolic reprograming Glycolysis Gluconeogenesis Fatty acids Mevalonate |
| title | The role of YAP/TAZ activity in cancer metabolic reprogramming |
| title_full | The role of YAP/TAZ activity in cancer metabolic reprogramming |
| title_fullStr | The role of YAP/TAZ activity in cancer metabolic reprogramming |
| title_full_unstemmed | The role of YAP/TAZ activity in cancer metabolic reprogramming |
| title_short | The role of YAP/TAZ activity in cancer metabolic reprogramming |
| title_sort | role of yap taz activity in cancer metabolic reprogramming |
| topic | YAP/TAZ Metabolic reprograming Glycolysis Gluconeogenesis Fatty acids Mevalonate |
| url | http://link.springer.com/article/10.1186/s12943-018-0882-1 |
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