Synaptic plasticity in hippocampal CA1 neurons and learning behavior in acute kidney injury, and estradiol replacement in ovariectomized rats
Abstract Background Neurological complications may occur in patients with acute or chronic renal failure; however, in cases of acute renal failure, the signs and symptoms are usually more pronounced, and progressed rapidly. Oxidative stress and nitric oxide in the hippocampus, following kidney injur...
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| Format: | Article |
| Language: | English |
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BMC
2019-10-01
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| Series: | BMC Neuroscience |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12868-019-0534-4 |
| _version_ | 1819009874875383808 |
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| author | Fatemeh Sharifi Parham Reisi Maryam Malek |
| author_facet | Fatemeh Sharifi Parham Reisi Maryam Malek |
| author_sort | Fatemeh Sharifi |
| collection | DOAJ |
| description | Abstract Background Neurological complications may occur in patients with acute or chronic renal failure; however, in cases of acute renal failure, the signs and symptoms are usually more pronounced, and progressed rapidly. Oxidative stress and nitric oxide in the hippocampus, following kidney injury may be involved in cognitive impairment in patients with uremia. Although many women continue taking hormone therapy for menopausal symptom relief, but there are also some controversies about the efficacy of exogenous sex hormones, especially estrogen therapy alone, in postmenopausal women with kidney injury. Herein, to the best of our knowledge for the first time, spatial memory and synaptic plasticity at the CA1 synapse of a uremic ovariectomized rat model of menopause was characterized by estradiol replacement alone. Results While estradiol replacement in ovariectomized rats without uremia, promotes synaptic plasticity, it has an impairing effect on spatial memory through hippocampal oxidative stress under uremic conditions, with no change on synaptic plasticity. It seems that exogenous estradiol potentiated the deleterious effect of acute kidney injury (AKI) with increasing hippocampal oxidative stress. Conclusions Although, estrogen may have some positive effects on cognitive function in healthy subjects, but its efficacy in menopause subjects under uremic states such as renal transplantation, needs to be further investigated in terms of dosage and duration. |
| first_indexed | 2024-12-21T01:03:18Z |
| format | Article |
| id | doaj.art-e9319be98d4e486f94c8da7200d149da |
| institution | Directory Open Access Journal |
| issn | 1471-2202 |
| language | English |
| last_indexed | 2024-12-21T01:03:18Z |
| publishDate | 2019-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neuroscience |
| spelling | doaj.art-e9319be98d4e486f94c8da7200d149da2022-12-21T19:21:07ZengBMCBMC Neuroscience1471-22022019-10-0120111010.1186/s12868-019-0534-4Synaptic plasticity in hippocampal CA1 neurons and learning behavior in acute kidney injury, and estradiol replacement in ovariectomized ratsFatemeh Sharifi0Parham Reisi1Maryam Malek2Department of Physiology, School of Medicine, Isfahan University of Medical SciencesDepartment of Physiology, School of Medicine, Isfahan University of Medical SciencesDepartment of Physiology, School of Medicine, Isfahan University of Medical SciencesAbstract Background Neurological complications may occur in patients with acute or chronic renal failure; however, in cases of acute renal failure, the signs and symptoms are usually more pronounced, and progressed rapidly. Oxidative stress and nitric oxide in the hippocampus, following kidney injury may be involved in cognitive impairment in patients with uremia. Although many women continue taking hormone therapy for menopausal symptom relief, but there are also some controversies about the efficacy of exogenous sex hormones, especially estrogen therapy alone, in postmenopausal women with kidney injury. Herein, to the best of our knowledge for the first time, spatial memory and synaptic plasticity at the CA1 synapse of a uremic ovariectomized rat model of menopause was characterized by estradiol replacement alone. Results While estradiol replacement in ovariectomized rats without uremia, promotes synaptic plasticity, it has an impairing effect on spatial memory through hippocampal oxidative stress under uremic conditions, with no change on synaptic plasticity. It seems that exogenous estradiol potentiated the deleterious effect of acute kidney injury (AKI) with increasing hippocampal oxidative stress. Conclusions Although, estrogen may have some positive effects on cognitive function in healthy subjects, but its efficacy in menopause subjects under uremic states such as renal transplantation, needs to be further investigated in terms of dosage and duration.http://link.springer.com/article/10.1186/s12868-019-0534-4Synaptic plasticityHippocampusLearning and memoryAcute kidney injuryEstradiol replacementOvariectomized rats |
| spellingShingle | Fatemeh Sharifi Parham Reisi Maryam Malek Synaptic plasticity in hippocampal CA1 neurons and learning behavior in acute kidney injury, and estradiol replacement in ovariectomized rats BMC Neuroscience Synaptic plasticity Hippocampus Learning and memory Acute kidney injury Estradiol replacement Ovariectomized rats |
| title | Synaptic plasticity in hippocampal CA1 neurons and learning behavior in acute kidney injury, and estradiol replacement in ovariectomized rats |
| title_full | Synaptic plasticity in hippocampal CA1 neurons and learning behavior in acute kidney injury, and estradiol replacement in ovariectomized rats |
| title_fullStr | Synaptic plasticity in hippocampal CA1 neurons and learning behavior in acute kidney injury, and estradiol replacement in ovariectomized rats |
| title_full_unstemmed | Synaptic plasticity in hippocampal CA1 neurons and learning behavior in acute kidney injury, and estradiol replacement in ovariectomized rats |
| title_short | Synaptic plasticity in hippocampal CA1 neurons and learning behavior in acute kidney injury, and estradiol replacement in ovariectomized rats |
| title_sort | synaptic plasticity in hippocampal ca1 neurons and learning behavior in acute kidney injury and estradiol replacement in ovariectomized rats |
| topic | Synaptic plasticity Hippocampus Learning and memory Acute kidney injury Estradiol replacement Ovariectomized rats |
| url | http://link.springer.com/article/10.1186/s12868-019-0534-4 |
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