Higher Body Mass Index is associated with increased arterial stiffness prior to target organ damage: a cross-sectional cohort study
Abstract Background Obesity is associated with several neurohumoral changes that play an essential role in organ damage. Increased arterial stiffness causes functional vessel wall changes and can therefore lead to accelerated target organ damage as well. Whether obesity causes an independent increas...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-09-01
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| Series: | BMC Cardiovascular Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12872-023-03503-5 |
| _version_ | 1797453983989628928 |
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| author | Nejc Piko Sebastjan Bevc Radovan Hojs Tadej Petreski Robert Ekart |
| author_facet | Nejc Piko Sebastjan Bevc Radovan Hojs Tadej Petreski Robert Ekart |
| author_sort | Nejc Piko |
| collection | DOAJ |
| description | Abstract Background Obesity is associated with several neurohumoral changes that play an essential role in organ damage. Increased arterial stiffness causes functional vessel wall changes and can therefore lead to accelerated target organ damage as well. Whether obesity causes an independent increase in central arterial stiffness is, however, not yet fully known. Methods One hundred thirty-three patients (63.2% male) were included. Body Mass Index (BMI) was defined as body weight in kilograms, divided by the square of body height in meters. Chronic Kidney Disease Epidemiology Collaboration creatinine 2009 equation was used to estimate the glomerular filtration rate (eGFR). Non-invasive applanation tonometry was used for arterial stiffness measurements (Sphygmocor Atcor Medical, Sydney, Australia). All patients underwent coronarography. Results The mean age of our patients was 65.0 ± 9.2 years. Their mean BMI was 28.5 ± 4.4 kg/m2, eGFR 75.5 ± 17.2 ml/min/1.73 m2 and ankle-brachial index (ABI) 1.0 ± 0.1. Their arterial stiffness measurements showed mean carotid-femoral pulse wave velocity (cfPWV) 10.3 ± 2.7 m/s, subendocardial viability ratio (SEVR) 164.4 ± 35.0%, and pulse pressure (PP) 47.8 ± 14.5 mmHg. Spearman's correlation test revealed a statistically significant correlation between BMI and SEVR (r = -0.193; p = 0.026), BMI and cfPWV (r = 0.417; p < 0.001) and between BMI and PP (r = 0.227; p = 0.009). Multiple regression analysis confirmed an independent connection between BMI and cfPWV (B = 0.303; p < 0.001) and between BMI and SEVR (B = -0.186; p = 0.040). There was no association between BMI and kidney function, ABI, or coronary artery disease. Conclusion Increased BMI is independently associated with augmented central arterial stiffness and reduced subendocardial perfusion but not with coronary artery disease, kidney function, or ABI. |
| first_indexed | 2024-03-09T15:30:41Z |
| format | Article |
| id | doaj.art-e932be495a7f449aa5be85c4bcdd6cdb |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-03-09T15:30:41Z |
| publishDate | 2023-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-e932be495a7f449aa5be85c4bcdd6cdb2023-11-26T12:16:42ZengBMCBMC Cardiovascular Disorders1471-22612023-09-012311910.1186/s12872-023-03503-5Higher Body Mass Index is associated with increased arterial stiffness prior to target organ damage: a cross-sectional cohort studyNejc Piko0Sebastjan Bevc1Radovan Hojs2Tadej Petreski3Robert Ekart4Department of Dialysis, Clinic for Internal Medicine, University Medical Centre MariborDepartment of Nephrology, Clinic for Internal Medicine, University Medical Centre MariborDepartment of Nephrology, Clinic for Internal Medicine, University Medical Centre MariborDepartment of Nephrology, Clinic for Internal Medicine, University Medical Centre MariborDepartment of Dialysis, Clinic for Internal Medicine, University Medical Centre MariborAbstract Background Obesity is associated with several neurohumoral changes that play an essential role in organ damage. Increased arterial stiffness causes functional vessel wall changes and can therefore lead to accelerated target organ damage as well. Whether obesity causes an independent increase in central arterial stiffness is, however, not yet fully known. Methods One hundred thirty-three patients (63.2% male) were included. Body Mass Index (BMI) was defined as body weight in kilograms, divided by the square of body height in meters. Chronic Kidney Disease Epidemiology Collaboration creatinine 2009 equation was used to estimate the glomerular filtration rate (eGFR). Non-invasive applanation tonometry was used for arterial stiffness measurements (Sphygmocor Atcor Medical, Sydney, Australia). All patients underwent coronarography. Results The mean age of our patients was 65.0 ± 9.2 years. Their mean BMI was 28.5 ± 4.4 kg/m2, eGFR 75.5 ± 17.2 ml/min/1.73 m2 and ankle-brachial index (ABI) 1.0 ± 0.1. Their arterial stiffness measurements showed mean carotid-femoral pulse wave velocity (cfPWV) 10.3 ± 2.7 m/s, subendocardial viability ratio (SEVR) 164.4 ± 35.0%, and pulse pressure (PP) 47.8 ± 14.5 mmHg. Spearman's correlation test revealed a statistically significant correlation between BMI and SEVR (r = -0.193; p = 0.026), BMI and cfPWV (r = 0.417; p < 0.001) and between BMI and PP (r = 0.227; p = 0.009). Multiple regression analysis confirmed an independent connection between BMI and cfPWV (B = 0.303; p < 0.001) and between BMI and SEVR (B = -0.186; p = 0.040). There was no association between BMI and kidney function, ABI, or coronary artery disease. Conclusion Increased BMI is independently associated with augmented central arterial stiffness and reduced subendocardial perfusion but not with coronary artery disease, kidney function, or ABI.https://doi.org/10.1186/s12872-023-03503-5ObesityAtherosclerosisArterial stiffnessCardiovascular diseaseChronic kidney disease |
| spellingShingle | Nejc Piko Sebastjan Bevc Radovan Hojs Tadej Petreski Robert Ekart Higher Body Mass Index is associated with increased arterial stiffness prior to target organ damage: a cross-sectional cohort study BMC Cardiovascular Disorders Obesity Atherosclerosis Arterial stiffness Cardiovascular disease Chronic kidney disease |
| title | Higher Body Mass Index is associated with increased arterial stiffness prior to target organ damage: a cross-sectional cohort study |
| title_full | Higher Body Mass Index is associated with increased arterial stiffness prior to target organ damage: a cross-sectional cohort study |
| title_fullStr | Higher Body Mass Index is associated with increased arterial stiffness prior to target organ damage: a cross-sectional cohort study |
| title_full_unstemmed | Higher Body Mass Index is associated with increased arterial stiffness prior to target organ damage: a cross-sectional cohort study |
| title_short | Higher Body Mass Index is associated with increased arterial stiffness prior to target organ damage: a cross-sectional cohort study |
| title_sort | higher body mass index is associated with increased arterial stiffness prior to target organ damage a cross sectional cohort study |
| topic | Obesity Atherosclerosis Arterial stiffness Cardiovascular disease Chronic kidney disease |
| url | https://doi.org/10.1186/s12872-023-03503-5 |
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