In Vitro Evaluation of a Nanoparticle-Based mRNA Delivery System for Cells in the Joint

In Vitro Evaluation of a Nanoparticle-Based mRNA Delivery System for Cells in the Joint

Biodegradable and bioresponsive polymer-based nanoparticles (NPs) can be used for oligonucleotide delivery, making them a promising candidate for mRNA-based therapeutics. In this study, we evaluated and optimized the efficiency of a cationic, hyperbranched poly(amidoamine)s-based nanoparticle system...

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Bibliographic Details
Main Authors: Lisa Sturm, Bettina Schwemberger, Ursula Menzel, Sonja Häckel, Christoph E. Albers, Christian Plank, Jaap Rip, Mauro Alini, Andreas Traweger, Sibylle Grad, Valentina Basoli
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Biomedicines
Subjects:
transfection
bioresponsive polymer-based nanoparticles
joint therapies
therapeutic mRNA
biologicals
Online Access:https://www.mdpi.com/2227-9059/9/7/794

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