Neural Basis of Response Bias on the Stop Signal Task in Misophonia
Objective: Misophonia is a newly described condition in which specific ordinary sounds provoke disproportionately strong negative affect. Since evidence for psychobiological dysfunction underlying misophonia is scarce, we tested whether misophonia patients, like many patients with impulse control or...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-10-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fpsyt.2019.00765/full |
| _version_ | 1828878367455182848 |
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| author | Nadine Eijsker Nadine Eijsker Arjan Schröder Arjan Schröder Dirk J. A. Smit Dirk J. A. Smit Guido van Wingen Guido van Wingen Damiaan Denys Damiaan Denys |
| author_facet | Nadine Eijsker Nadine Eijsker Arjan Schröder Arjan Schröder Dirk J. A. Smit Dirk J. A. Smit Guido van Wingen Guido van Wingen Damiaan Denys Damiaan Denys |
| author_sort | Nadine Eijsker |
| collection | DOAJ |
| description | Objective: Misophonia is a newly described condition in which specific ordinary sounds provoke disproportionately strong negative affect. Since evidence for psychobiological dysfunction underlying misophonia is scarce, we tested whether misophonia patients, like many patients with impulse control or obsessive-compulsive spectrum disorders, show impaired ability to inhibit an ongoing motor response.Methods: We collected functional magnetic resonance imaging data during a stop signal task in 22 misophonia patients and 21 matched healthy controls.Results: Compared to controls, patients tended to show longer stop signal delays, which is the time between stimuli signaling response initiation and inhibition. Additionally, patients tended to activate left dorsolateral prefrontal cortex more during responding rather than successful inhibition, as was seen in controls. Furthermore, patients lacked inhibition success-related activity in posterior cingulate cortices and activated the superior medial frontal gyri less during inhibition success compared to failure, a feature correlated with stop signal delays over the sample.Conclusions: Misophonia patients did not show impaired response inhibition. However, they tended to show a response bias on the stop signal task, favoring accuracy over speed. This implies perfectionism and compulsive, rather than impulsive, behavior. Moreover, brain activations were in line with patients, compared to controls, engaging more cognitive control for slowing responses, while employing more attentional resources for successful inhibition. |
| first_indexed | 2024-12-13T09:05:01Z |
| format | Article |
| id | doaj.art-e9354394a8b8421fb21d0df76beedae4 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-13T09:05:01Z |
| publishDate | 2019-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-e9354394a8b8421fb21d0df76beedae42022-12-21T23:53:06ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402019-10-011010.3389/fpsyt.2019.00765432128Neural Basis of Response Bias on the Stop Signal Task in MisophoniaNadine Eijsker0Nadine Eijsker1Arjan Schröder2Arjan Schröder3Dirk J. A. Smit4Dirk J. A. Smit5Guido van Wingen6Guido van Wingen7Damiaan Denys8Damiaan Denys9Department of Psychiatry, Amsterdam Neuroscience, Amsterdam UMC, University of Amsterdam, Amsterdam, NetherlandsAmsterdam Brain and Cognition, University of Amsterdam, Amsterdam, NetherlandsDepartment of Psychiatry, Amsterdam Neuroscience, Amsterdam UMC, University of Amsterdam, Amsterdam, NetherlandsAmsterdam Brain and Cognition, University of Amsterdam, Amsterdam, NetherlandsDepartment of Psychiatry, Amsterdam Neuroscience, Amsterdam UMC, University of Amsterdam, Amsterdam, NetherlandsAmsterdam Brain and Cognition, University of Amsterdam, Amsterdam, NetherlandsDepartment of Psychiatry, Amsterdam Neuroscience, Amsterdam UMC, University of Amsterdam, Amsterdam, NetherlandsAmsterdam Brain and Cognition, University of Amsterdam, Amsterdam, NetherlandsDepartment of Psychiatry, Amsterdam Neuroscience, Amsterdam UMC, University of Amsterdam, Amsterdam, NetherlandsAmsterdam Brain and Cognition, University of Amsterdam, Amsterdam, NetherlandsObjective: Misophonia is a newly described condition in which specific ordinary sounds provoke disproportionately strong negative affect. Since evidence for psychobiological dysfunction underlying misophonia is scarce, we tested whether misophonia patients, like many patients with impulse control or obsessive-compulsive spectrum disorders, show impaired ability to inhibit an ongoing motor response.Methods: We collected functional magnetic resonance imaging data during a stop signal task in 22 misophonia patients and 21 matched healthy controls.Results: Compared to controls, patients tended to show longer stop signal delays, which is the time between stimuli signaling response initiation and inhibition. Additionally, patients tended to activate left dorsolateral prefrontal cortex more during responding rather than successful inhibition, as was seen in controls. Furthermore, patients lacked inhibition success-related activity in posterior cingulate cortices and activated the superior medial frontal gyri less during inhibition success compared to failure, a feature correlated with stop signal delays over the sample.Conclusions: Misophonia patients did not show impaired response inhibition. However, they tended to show a response bias on the stop signal task, favoring accuracy over speed. This implies perfectionism and compulsive, rather than impulsive, behavior. Moreover, brain activations were in line with patients, compared to controls, engaging more cognitive control for slowing responses, while employing more attentional resources for successful inhibition.https://www.frontiersin.org/article/10.3389/fpsyt.2019.00765/fullmisophoniafunctional magnetic resonance imagingstop signal taskresponse biasperfectionismcompulsivity |
| spellingShingle | Nadine Eijsker Nadine Eijsker Arjan Schröder Arjan Schröder Dirk J. A. Smit Dirk J. A. Smit Guido van Wingen Guido van Wingen Damiaan Denys Damiaan Denys Neural Basis of Response Bias on the Stop Signal Task in Misophonia Frontiers in Psychiatry misophonia functional magnetic resonance imaging stop signal task response bias perfectionism compulsivity |
| title | Neural Basis of Response Bias on the Stop Signal Task in Misophonia |
| title_full | Neural Basis of Response Bias on the Stop Signal Task in Misophonia |
| title_fullStr | Neural Basis of Response Bias on the Stop Signal Task in Misophonia |
| title_full_unstemmed | Neural Basis of Response Bias on the Stop Signal Task in Misophonia |
| title_short | Neural Basis of Response Bias on the Stop Signal Task in Misophonia |
| title_sort | neural basis of response bias on the stop signal task in misophonia |
| topic | misophonia functional magnetic resonance imaging stop signal task response bias perfectionism compulsivity |
| url | https://www.frontiersin.org/article/10.3389/fpsyt.2019.00765/full |
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