Atypical magnetic resonance imaging features in subacute sclerosing panencephalitis

Objectives: Subacute sclerosing panencephalitis (SSPE) is rare chronic, progressive encephalitis that affects primarily children and young adults, caused by a persistent infection with measles virus. No cure for SSPE exists, but the condition can be managed by medication if treatment is started at a...

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Main Authors: Biplab Das, Manoj Kumar Goyal, Manish Modi, Sahil Mehta, Sudheer Chakravarthi, Vivek Lal, Sameer Vyas
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2016-01-01
Series:Annals of Indian Academy of Neurology
Subjects:
Online Access:http://www.annalsofian.org/article.asp?issn=0972-2327;year=2016;volume=19;issue=2;spage=275;epage=276;aulast=Das
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author Biplab Das
Manoj Kumar Goyal
Manish Modi
Sahil Mehta
Sudheer Chakravarthi
Vivek Lal
Sameer Vyas
author_facet Biplab Das
Manoj Kumar Goyal
Manish Modi
Sahil Mehta
Sudheer Chakravarthi
Vivek Lal
Sameer Vyas
author_sort Biplab Das
collection DOAJ
description Objectives: Subacute sclerosing panencephalitis (SSPE) is rare chronic, progressive encephalitis that affects primarily children and young adults, caused by a persistent infection with measles virus. No cure for SSPE exists, but the condition can be managed by medication if treatment is started at an early stage. Methods and Results: Heterogeneity of imaging findings in SSPE is not very uncommon. But pial and gyral enhancements are very rarely noticed. Significant asymmetric onset as well as pial-gyral enhancements is not reported. Herein we present a case of 16 years adolescent of SSPE having remarkable asymmetric pial-gyral enhancements, which were misinterpreted as tubercular infection. Conclusion: Early diagnosis and treatment is encouraging in SSPE, although it is not curable with current therapy. Clinico-radiological and electrophysiological correlation is very important in diagnosis of SSPE, more gravely in patients having atypical image findings as in our index case.
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spelling doaj.art-e93558dab0f34ee5bf419fe3fbc806a12022-12-21T22:49:36ZengWolters Kluwer Medknow PublicationsAnnals of Indian Academy of Neurology0972-23271998-35492016-01-0119227527610.4103/0972-2327.173304Atypical magnetic resonance imaging features in subacute sclerosing panencephalitisBiplab DasManoj Kumar GoyalManish ModiSahil MehtaSudheer ChakravarthiVivek LalSameer VyasObjectives: Subacute sclerosing panencephalitis (SSPE) is rare chronic, progressive encephalitis that affects primarily children and young adults, caused by a persistent infection with measles virus. No cure for SSPE exists, but the condition can be managed by medication if treatment is started at an early stage. Methods and Results: Heterogeneity of imaging findings in SSPE is not very uncommon. But pial and gyral enhancements are very rarely noticed. Significant asymmetric onset as well as pial-gyral enhancements is not reported. Herein we present a case of 16 years adolescent of SSPE having remarkable asymmetric pial-gyral enhancements, which were misinterpreted as tubercular infection. Conclusion: Early diagnosis and treatment is encouraging in SSPE, although it is not curable with current therapy. Clinico-radiological and electrophysiological correlation is very important in diagnosis of SSPE, more gravely in patients having atypical image findings as in our index case.http://www.annalsofian.org/article.asp?issn=0972-2327;year=2016;volume=19;issue=2;spage=275;epage=276;aulast=DasEncephalitismeaslesmyoclonic jerkspial and gyral enhancementsubacute sclerosing panencephalitis (SSPE)
spellingShingle Biplab Das
Manoj Kumar Goyal
Manish Modi
Sahil Mehta
Sudheer Chakravarthi
Vivek Lal
Sameer Vyas
Atypical magnetic resonance imaging features in subacute sclerosing panencephalitis
Annals of Indian Academy of Neurology
Encephalitis
measles
myoclonic jerks
pial and gyral enhancement
subacute sclerosing panencephalitis (SSPE)
title Atypical magnetic resonance imaging features in subacute sclerosing panencephalitis
title_full Atypical magnetic resonance imaging features in subacute sclerosing panencephalitis
title_fullStr Atypical magnetic resonance imaging features in subacute sclerosing panencephalitis
title_full_unstemmed Atypical magnetic resonance imaging features in subacute sclerosing panencephalitis
title_short Atypical magnetic resonance imaging features in subacute sclerosing panencephalitis
title_sort atypical magnetic resonance imaging features in subacute sclerosing panencephalitis
topic Encephalitis
measles
myoclonic jerks
pial and gyral enhancement
subacute sclerosing panencephalitis (SSPE)
url http://www.annalsofian.org/article.asp?issn=0972-2327;year=2016;volume=19;issue=2;spage=275;epage=276;aulast=Das
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AT manojkumargoyal atypicalmagneticresonanceimagingfeaturesinsubacutesclerosingpanencephalitis
AT manishmodi atypicalmagneticresonanceimagingfeaturesinsubacutesclerosingpanencephalitis
AT sahilmehta atypicalmagneticresonanceimagingfeaturesinsubacutesclerosingpanencephalitis
AT sudheerchakravarthi atypicalmagneticresonanceimagingfeaturesinsubacutesclerosingpanencephalitis
AT viveklal atypicalmagneticresonanceimagingfeaturesinsubacutesclerosingpanencephalitis
AT sameervyas atypicalmagneticresonanceimagingfeaturesinsubacutesclerosingpanencephalitis