Neonatal sepsis, clinical manifestation, diagnosis and treatment
Sepsis is a severe illness during the neonatal period. Despite significant advances in the care of newborn infants, sepsis remains a leading cause of neonatal morbidity and mortality. The overall incidence of neonatal sepsis ranges from 1 to 5 cases per 1,000 births and case fatality rates (CFRs) ra...
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| Format: | Article |
| Language: | English |
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Kazimierz Wielki University
2019-04-01
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| Series: | Journal of Education, Health and Sport |
| Subjects: | |
| Online Access: | https://apcz.umk.pl/JEHS/article/view/25546 |
| _version_ | 1811303342137147392 |
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| author | Uliana Ivanivna Marusyk Olena Vasylivna Vlasova Maryana Ivanivna Hrytsiuk Valentyna Volodymyrivna Bebykh |
| author_facet | Uliana Ivanivna Marusyk Olena Vasylivna Vlasova Maryana Ivanivna Hrytsiuk Valentyna Volodymyrivna Bebykh |
| author_sort | Uliana Ivanivna Marusyk |
| collection | DOAJ |
| description | Sepsis is a severe illness during the neonatal period. Despite significant advances in the care of newborn infants, sepsis remains a leading cause of neonatal morbidity and mortality. The overall incidence of neonatal sepsis ranges from 1 to 5 cases per 1,000 births and case fatality rates (CFRs) range from 2 % to 60 %. Both rates depend on multiple factors, such as pathogen distribution, gestational age, Streptococcus agalactiae (group B Streptococcus, GBS) carriage rates and prevalence of other common specific pathogens.
Most types of microorganisms can cause sepsis, including bacteria, fungi, viruses and parasites, such as those that cause malaria. Bacteria such as Streptococcus pneumoniae, Haemophilus influenzae, Staphylococcus aureus, Escherichia coli, Salmonella and Neisseria meningitidis are the most common etiological pathogens. Manifestations of sepsis and septic shock can be the fatal frequent pathway of infections with seasonal influenza viruses, dengue viruses and highly transmissible pathogens of public health concern such as avian and swine influenza viruses, severe acute respiratory syndrome coronavirus, Middle East respiratory syndrome coronavirus and most recently, Ebola and yellow fever viruses.
It is descriptive, non-experimental study. The aim of it is to specify the etiologic factors, clinical manifestation, diagnostic criteria and treatment of sepsis.
Based on the results of the study conclusion is that the use of non-culture based diagnostics and sepsis scores to predict and diagnose septic neonates are areas of active investigation. The next frontier for antibiotic stewardship in the neonatal intensive care unit must be development of strategies to decrease antibiotic use and minimise adverse effects by a thorough study of duration of therapy. |
| first_indexed | 2024-04-13T07:46:17Z |
| format | Article |
| id | doaj.art-e936b0acbba74801a0989ca8c261fdfa |
| institution | Directory Open Access Journal |
| issn | 2391-8306 |
| language | English |
| last_indexed | 2024-04-13T07:46:17Z |
| publishDate | 2019-04-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj.art-e936b0acbba74801a0989ca8c261fdfa2022-12-22T02:55:41ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062019-04-0194Neonatal sepsis, clinical manifestation, diagnosis and treatmentUliana Ivanivna Marusyk0Olena Vasylivna Vlasova1Maryana Ivanivna Hrytsiuk2Valentyna Volodymyrivna Bebykh3Bukovinan State Medical UniversityBukovinan State Medical UniversityBukovinan State Medical UniversityBukovinan State Medical UniversitySepsis is a severe illness during the neonatal period. Despite significant advances in the care of newborn infants, sepsis remains a leading cause of neonatal morbidity and mortality. The overall incidence of neonatal sepsis ranges from 1 to 5 cases per 1,000 births and case fatality rates (CFRs) range from 2 % to 60 %. Both rates depend on multiple factors, such as pathogen distribution, gestational age, Streptococcus agalactiae (group B Streptococcus, GBS) carriage rates and prevalence of other common specific pathogens. Most types of microorganisms can cause sepsis, including bacteria, fungi, viruses and parasites, such as those that cause malaria. Bacteria such as Streptococcus pneumoniae, Haemophilus influenzae, Staphylococcus aureus, Escherichia coli, Salmonella and Neisseria meningitidis are the most common etiological pathogens. Manifestations of sepsis and septic shock can be the fatal frequent pathway of infections with seasonal influenza viruses, dengue viruses and highly transmissible pathogens of public health concern such as avian and swine influenza viruses, severe acute respiratory syndrome coronavirus, Middle East respiratory syndrome coronavirus and most recently, Ebola and yellow fever viruses. It is descriptive, non-experimental study. The aim of it is to specify the etiologic factors, clinical manifestation, diagnostic criteria and treatment of sepsis. Based on the results of the study conclusion is that the use of non-culture based diagnostics and sepsis scores to predict and diagnose septic neonates are areas of active investigation. The next frontier for antibiotic stewardship in the neonatal intensive care unit must be development of strategies to decrease antibiotic use and minimise adverse effects by a thorough study of duration of therapy.https://apcz.umk.pl/JEHS/article/view/25546Neonatal sepsiscomplete blood countblood cultureantimicrobial therapy |
| spellingShingle | Uliana Ivanivna Marusyk Olena Vasylivna Vlasova Maryana Ivanivna Hrytsiuk Valentyna Volodymyrivna Bebykh Neonatal sepsis, clinical manifestation, diagnosis and treatment Journal of Education, Health and Sport Neonatal sepsis complete blood count blood culture antimicrobial therapy |
| title | Neonatal sepsis, clinical manifestation, diagnosis and treatment |
| title_full | Neonatal sepsis, clinical manifestation, diagnosis and treatment |
| title_fullStr | Neonatal sepsis, clinical manifestation, diagnosis and treatment |
| title_full_unstemmed | Neonatal sepsis, clinical manifestation, diagnosis and treatment |
| title_short | Neonatal sepsis, clinical manifestation, diagnosis and treatment |
| title_sort | neonatal sepsis clinical manifestation diagnosis and treatment |
| topic | Neonatal sepsis complete blood count blood culture antimicrobial therapy |
| url | https://apcz.umk.pl/JEHS/article/view/25546 |
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