Analysis of Intestinal Microbiota and Metabolic Pathways before and after a 2-Month-Long Hydrolyzed Fish and Rice Starch Hypoallergenic Diet Trial in Pruritic Dogs
Intestinal microbiota alterations were described in allergic individuals and may improve with diets. Farmina Ultra Hypo (FUH), a hydrolyzed fish/rice starch hypoallergenic diet, is able to improve clinical signs in allergic dogs. Study objectives were to determine microbiota differences in allergic...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-07-01
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| Series: | Veterinary Sciences |
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| Online Access: | https://www.mdpi.com/2306-7381/10/7/478 |
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| author | Chiara Noli Antonella Varina Caterina Barbieri Alessandra Pirola Daniela Olivero |
| author_facet | Chiara Noli Antonella Varina Caterina Barbieri Alessandra Pirola Daniela Olivero |
| author_sort | Chiara Noli |
| collection | DOAJ |
| description | Intestinal microbiota alterations were described in allergic individuals and may improve with diets. Farmina Ultra Hypo (FUH), a hydrolyzed fish/rice starch hypoallergenic diet, is able to improve clinical signs in allergic dogs. Study objectives were to determine microbiota differences in allergic dogs before and after feeding with FUH for eight weeks. Forty skin allergic dogs were evaluated clinically before and after the diet. Unresponsive dogs were classified as canine atopic dermatitis (CAD); responsive dogs relapsing after challenge with previous foods were classified as being food reactive (AFR), and those not relapsing as doubtful (D). Sequencing of feces collected pre- and post-diet was performed, with comparisons between and within groups, pre- and post-diet, and correlations to possible altered metabolic pathways were sought. Microbiota in all dogs was dominated by <i>Bacteroidota</i>, <i>Fusobacteriota</i>, <i>Firmicutes</i> and <i>Proteobacteria</i>, albeit with large interindividual variations and with some prevalence changes after the diet. In general, bacteria producing short-chain fatty acids were increased in all samples. CAD dogs showed pre-and post-diet microbiota patterns different from the other two groups. Bacteria taxa were enriched post-diet only in the AFR group. Changes in metabolic pathways were observed mainly in the CAD group. FUH may be able to improve intestinal microbiota and thus clinical signs of skin allergy. |
| first_indexed | 2024-03-11T00:34:43Z |
| format | Article |
| id | doaj.art-e93ac31d0c6f41828ee848c2b9d4e2c9 |
| institution | Directory Open Access Journal |
| issn | 2306-7381 |
| language | English |
| last_indexed | 2024-03-11T00:34:43Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Veterinary Sciences |
| spelling | doaj.art-e93ac31d0c6f41828ee848c2b9d4e2c92023-11-18T21:43:11ZengMDPI AGVeterinary Sciences2306-73812023-07-0110747810.3390/vetsci10070478Analysis of Intestinal Microbiota and Metabolic Pathways before and after a 2-Month-Long Hydrolyzed Fish and Rice Starch Hypoallergenic Diet Trial in Pruritic DogsChiara Noli0Antonella Varina1Caterina Barbieri2Alessandra Pirola3Daniela Olivero4Servizi Dermatologici Veterinari, Strada Bedale della Ressia 2, 12016 Peveragno, ItalyAmbulatorio Veterinario Varina-Ghidella-Scarfone, Via Fréjus 54, 10139 Torino, ItalyGalSeq s.r.l., Via Ludovico Ariosto 21, 20091 Bresso, ItalyGalSeq s.r.l., Via Ludovico Ariosto 21, 20091 Bresso, ItalyLaboratorio Analisi Veterinarie BiEsseA Scilvet, Via Amedeo d’Aosta 7, 20129 Milano, ItalyIntestinal microbiota alterations were described in allergic individuals and may improve with diets. Farmina Ultra Hypo (FUH), a hydrolyzed fish/rice starch hypoallergenic diet, is able to improve clinical signs in allergic dogs. Study objectives were to determine microbiota differences in allergic dogs before and after feeding with FUH for eight weeks. Forty skin allergic dogs were evaluated clinically before and after the diet. Unresponsive dogs were classified as canine atopic dermatitis (CAD); responsive dogs relapsing after challenge with previous foods were classified as being food reactive (AFR), and those not relapsing as doubtful (D). Sequencing of feces collected pre- and post-diet was performed, with comparisons between and within groups, pre- and post-diet, and correlations to possible altered metabolic pathways were sought. Microbiota in all dogs was dominated by <i>Bacteroidota</i>, <i>Fusobacteriota</i>, <i>Firmicutes</i> and <i>Proteobacteria</i>, albeit with large interindividual variations and with some prevalence changes after the diet. In general, bacteria producing short-chain fatty acids were increased in all samples. CAD dogs showed pre-and post-diet microbiota patterns different from the other two groups. Bacteria taxa were enriched post-diet only in the AFR group. Changes in metabolic pathways were observed mainly in the CAD group. FUH may be able to improve intestinal microbiota and thus clinical signs of skin allergy.https://www.mdpi.com/2306-7381/10/7/478dogallergic dermatitisfood allergypruritusskincanine atopic dermatitis |
| spellingShingle | Chiara Noli Antonella Varina Caterina Barbieri Alessandra Pirola Daniela Olivero Analysis of Intestinal Microbiota and Metabolic Pathways before and after a 2-Month-Long Hydrolyzed Fish and Rice Starch Hypoallergenic Diet Trial in Pruritic Dogs Veterinary Sciences dog allergic dermatitis food allergy pruritus skin canine atopic dermatitis |
| title | Analysis of Intestinal Microbiota and Metabolic Pathways before and after a 2-Month-Long Hydrolyzed Fish and Rice Starch Hypoallergenic Diet Trial in Pruritic Dogs |
| title_full | Analysis of Intestinal Microbiota and Metabolic Pathways before and after a 2-Month-Long Hydrolyzed Fish and Rice Starch Hypoallergenic Diet Trial in Pruritic Dogs |
| title_fullStr | Analysis of Intestinal Microbiota and Metabolic Pathways before and after a 2-Month-Long Hydrolyzed Fish and Rice Starch Hypoallergenic Diet Trial in Pruritic Dogs |
| title_full_unstemmed | Analysis of Intestinal Microbiota and Metabolic Pathways before and after a 2-Month-Long Hydrolyzed Fish and Rice Starch Hypoallergenic Diet Trial in Pruritic Dogs |
| title_short | Analysis of Intestinal Microbiota and Metabolic Pathways before and after a 2-Month-Long Hydrolyzed Fish and Rice Starch Hypoallergenic Diet Trial in Pruritic Dogs |
| title_sort | analysis of intestinal microbiota and metabolic pathways before and after a 2 month long hydrolyzed fish and rice starch hypoallergenic diet trial in pruritic dogs |
| topic | dog allergic dermatitis food allergy pruritus skin canine atopic dermatitis |
| url | https://www.mdpi.com/2306-7381/10/7/478 |
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