Age-specific association between non-HDL-C and arterial stiffness in the Chinese population
BackgroundWhile some epidemiological studies have found correlations between non-high-density lipoprotein cholesterol (non-HDL-C) and arterial stiffness, there are still exist controversial and age-stratified analysis are scarce yet.MethodsAll individuals in this study were recruited in the Third Xi...
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Frontiers Media S.A.
2022-09-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.981028/full |
| _version_ | 1811258688554401792 |
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| author | Jie Wang Jie Wang Rujia Miao Zhiheng Chen Jiangang Wang Hong Yuan Jing Li Zheng Huang |
| author_facet | Jie Wang Jie Wang Rujia Miao Zhiheng Chen Jiangang Wang Hong Yuan Jing Li Zheng Huang |
| author_sort | Jie Wang |
| collection | DOAJ |
| description | BackgroundWhile some epidemiological studies have found correlations between non-high-density lipoprotein cholesterol (non-HDL-C) and arterial stiffness, there are still exist controversial and age-stratified analysis are scarce yet.MethodsAll individuals in this study were recruited in the Third Xiangya Hospital of Central South University from 2012 to 2016. Arterial stiffness was defined as brachial-ankle pulse wave velocity (baPWV) ≥1,400 cm/s. Association between non-HDL-C and arterial stiffness were explored using Cox proportional-hazards model. We also conducted subanalysis stratified by age. Furthermore, restricted cubic splines were used to model exposure-response relationships in cohort sample.ResultsThis cohort study included 7,276 participants without arterial stiffness at baseline. Over a median follow-up of 1.78 years (IQR, 1.03–2.49), 1,669 participants have identified with incident arterial stiffness. In multivariable-adjusted analyses, higher non-HDL-C concentration was associated with incident arterial stiffness with an adjusted hazard ratio (HR) of 1.09 [95% confidence interval (CI), 1.02–1.17] per 1 mmol/L increase. Compared with the lowest tertile, the HR for arterial stiffness with respect to the highest tertile of non-HDL-C was 1.26 (95% CI, 1.07–1.48). The results were similar in the analysis of young participants (age <60 years).ConclusionOur study identified that non-HDL-C as a potential risk factor of arterial stiffness, especially for younger. The clinical benefits of decreasing non-HDL-C concentration should be further considered in the future. |
| first_indexed | 2024-04-12T18:18:20Z |
| format | Article |
| id | doaj.art-e93b83a2ed16422a8c7dce84ef9b7c18 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-12T18:18:20Z |
| publishDate | 2022-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-e93b83a2ed16422a8c7dce84ef9b7c182022-12-22T03:21:32ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-09-01910.3389/fcvm.2022.981028981028Age-specific association between non-HDL-C and arterial stiffness in the Chinese populationJie Wang0Jie Wang1Rujia Miao2Zhiheng Chen3Jiangang Wang4Hong Yuan5Jing Li6Zheng Huang7Clinical Research Center, The Third Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Cardiology, The Third Xiangya Hospital, Central South University, Changsha, ChinaHealth Management Center, The Third Xiangya Hospital, Central South University, Changsha, ChinaHealth Management Center, The Third Xiangya Hospital, Central South University, Changsha, ChinaHealth Management Center, The Third Xiangya Hospital, Central South University, Changsha, ChinaClinical Research Center, The Third Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Rehabilitation, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Neurosurgery, Xiangya Hospital, Central South University, Changsha, ChinaBackgroundWhile some epidemiological studies have found correlations between non-high-density lipoprotein cholesterol (non-HDL-C) and arterial stiffness, there are still exist controversial and age-stratified analysis are scarce yet.MethodsAll individuals in this study were recruited in the Third Xiangya Hospital of Central South University from 2012 to 2016. Arterial stiffness was defined as brachial-ankle pulse wave velocity (baPWV) ≥1,400 cm/s. Association between non-HDL-C and arterial stiffness were explored using Cox proportional-hazards model. We also conducted subanalysis stratified by age. Furthermore, restricted cubic splines were used to model exposure-response relationships in cohort sample.ResultsThis cohort study included 7,276 participants without arterial stiffness at baseline. Over a median follow-up of 1.78 years (IQR, 1.03–2.49), 1,669 participants have identified with incident arterial stiffness. In multivariable-adjusted analyses, higher non-HDL-C concentration was associated with incident arterial stiffness with an adjusted hazard ratio (HR) of 1.09 [95% confidence interval (CI), 1.02–1.17] per 1 mmol/L increase. Compared with the lowest tertile, the HR for arterial stiffness with respect to the highest tertile of non-HDL-C was 1.26 (95% CI, 1.07–1.48). The results were similar in the analysis of young participants (age <60 years).ConclusionOur study identified that non-HDL-C as a potential risk factor of arterial stiffness, especially for younger. The clinical benefits of decreasing non-HDL-C concentration should be further considered in the future.https://www.frontiersin.org/articles/10.3389/fcvm.2022.981028/fullPWVnon-HDL-Carterial stiffnessvascular healthage-specific |
| spellingShingle | Jie Wang Jie Wang Rujia Miao Zhiheng Chen Jiangang Wang Hong Yuan Jing Li Zheng Huang Age-specific association between non-HDL-C and arterial stiffness in the Chinese population Frontiers in Cardiovascular Medicine PWV non-HDL-C arterial stiffness vascular health age-specific |
| title | Age-specific association between non-HDL-C and arterial stiffness in the Chinese population |
| title_full | Age-specific association between non-HDL-C and arterial stiffness in the Chinese population |
| title_fullStr | Age-specific association between non-HDL-C and arterial stiffness in the Chinese population |
| title_full_unstemmed | Age-specific association between non-HDL-C and arterial stiffness in the Chinese population |
| title_short | Age-specific association between non-HDL-C and arterial stiffness in the Chinese population |
| title_sort | age specific association between non hdl c and arterial stiffness in the chinese population |
| topic | PWV non-HDL-C arterial stiffness vascular health age-specific |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.981028/full |
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