A biopotential optrode array: operation principles and simulations
Abstract We propose an optical electrode ’optrode’ sensor array for biopotential measurements. The transduction mechanism is based on deformed helix ferroelectric liquid crystals which realign, altering the optrode’s light reflectance properties, relative to applied potential fields of biological ce...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-02-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-018-20182-x |
| _version_ | 1818345813383839744 |
|---|---|
| author | Amr Al Abed Hrishikesh Srinivas Josiah Firth François Ladouceur Nigel H. Lovell Leonardo Silvestri |
| author_facet | Amr Al Abed Hrishikesh Srinivas Josiah Firth François Ladouceur Nigel H. Lovell Leonardo Silvestri |
| author_sort | Amr Al Abed |
| collection | DOAJ |
| description | Abstract We propose an optical electrode ’optrode’ sensor array for biopotential measurements. The transduction mechanism is based on deformed helix ferroelectric liquid crystals which realign, altering the optrode’s light reflectance properties, relative to applied potential fields of biological cells and tissue. A computational model of extracellular potential recording by the optrode including the electro-optical transduction mechanism is presented, using a combination of time-domain and frequency-domain finite element analysis. Simulations indicate that the device has appropriate temporal response to faithfully transduce neuronal spikes, and spatial resolution to capture impulse propagation along a single neuron. These simulations contribute to the development of multi-channel optrode arrays for spatio-temporal mapping of electric events in excitable biological tissue. |
| first_indexed | 2024-12-13T17:08:20Z |
| format | Article |
| id | doaj.art-e93b9bd01c724a949669ad35b777e33a |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-13T17:08:20Z |
| publishDate | 2018-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-e93b9bd01c724a949669ad35b777e33a2022-12-21T23:37:37ZengNature PortfolioScientific Reports2045-23222018-02-018111610.1038/s41598-018-20182-xA biopotential optrode array: operation principles and simulationsAmr Al Abed0Hrishikesh Srinivas1Josiah Firth2François Ladouceur3Nigel H. Lovell4Leonardo Silvestri5Graduate School of Biomedical Engineering, UNSWGraduate School of Biomedical Engineering, UNSWSchool of Electrical Engineering and Telecommunications, UNSWSchool of Electrical Engineering and Telecommunications, UNSWGraduate School of Biomedical Engineering, UNSWGraduate School of Biomedical Engineering, UNSWAbstract We propose an optical electrode ’optrode’ sensor array for biopotential measurements. The transduction mechanism is based on deformed helix ferroelectric liquid crystals which realign, altering the optrode’s light reflectance properties, relative to applied potential fields of biological cells and tissue. A computational model of extracellular potential recording by the optrode including the electro-optical transduction mechanism is presented, using a combination of time-domain and frequency-domain finite element analysis. Simulations indicate that the device has appropriate temporal response to faithfully transduce neuronal spikes, and spatial resolution to capture impulse propagation along a single neuron. These simulations contribute to the development of multi-channel optrode arrays for spatio-temporal mapping of electric events in excitable biological tissue.https://doi.org/10.1038/s41598-018-20182-x |
| spellingShingle | Amr Al Abed Hrishikesh Srinivas Josiah Firth François Ladouceur Nigel H. Lovell Leonardo Silvestri A biopotential optrode array: operation principles and simulations Scientific Reports |
| title | A biopotential optrode array: operation principles and simulations |
| title_full | A biopotential optrode array: operation principles and simulations |
| title_fullStr | A biopotential optrode array: operation principles and simulations |
| title_full_unstemmed | A biopotential optrode array: operation principles and simulations |
| title_short | A biopotential optrode array: operation principles and simulations |
| title_sort | biopotential optrode array operation principles and simulations |
| url | https://doi.org/10.1038/s41598-018-20182-x |
| work_keys_str_mv | AT amralabed abiopotentialoptrodearrayoperationprinciplesandsimulations AT hrishikeshsrinivas abiopotentialoptrodearrayoperationprinciplesandsimulations AT josiahfirth abiopotentialoptrodearrayoperationprinciplesandsimulations AT francoisladouceur abiopotentialoptrodearrayoperationprinciplesandsimulations AT nigelhlovell abiopotentialoptrodearrayoperationprinciplesandsimulations AT leonardosilvestri abiopotentialoptrodearrayoperationprinciplesandsimulations AT amralabed biopotentialoptrodearrayoperationprinciplesandsimulations AT hrishikeshsrinivas biopotentialoptrodearrayoperationprinciplesandsimulations AT josiahfirth biopotentialoptrodearrayoperationprinciplesandsimulations AT francoisladouceur biopotentialoptrodearrayoperationprinciplesandsimulations AT nigelhlovell biopotentialoptrodearrayoperationprinciplesandsimulations AT leonardosilvestri biopotentialoptrodearrayoperationprinciplesandsimulations |