Lipid indices as simple and clinically useful surrogate markers for insulin resistance in the U.S. population
Abstract This study aimed to compare the accuracy of novel lipid indices, including the visceral adiposity index (VAI), lipid accumulation product (LAP), triglycerides and glucose (TyG) index, TyG-body mass index (TyG-BMI), and TyG-waist circumference (TyG-WC), in identifying insulin resistance and...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-82053-2 |
| _version_ | 1818735362109865984 |
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| author | Juncheol Lee Bongyoung Kim Wonhee Kim Chiwon Ahn Hyun Young Choi Jae Guk Kim Jihoon Kim Hyungoo Shin Jun Goo Kang Shinje Moon |
| author_facet | Juncheol Lee Bongyoung Kim Wonhee Kim Chiwon Ahn Hyun Young Choi Jae Guk Kim Jihoon Kim Hyungoo Shin Jun Goo Kang Shinje Moon |
| author_sort | Juncheol Lee |
| collection | DOAJ |
| description | Abstract This study aimed to compare the accuracy of novel lipid indices, including the visceral adiposity index (VAI), lipid accumulation product (LAP), triglycerides and glucose (TyG) index, TyG-body mass index (TyG-BMI), and TyG-waist circumference (TyG-WC), in identifying insulin resistance and establish valid cutoff values. This cross-sectional study used the data of 11,378 adults, derived from the United States National Health and Nutrition Examination Survey (1999–2016). Insulin resistance was defined as a homeostasis model assessment-insulin resistance value above the 75th percentile for each sex and race/ethnicities. The area under the curves (AUCs) were as follows: VAI, 0.735; LAP, 0.796; TyG index, 0.723; TyG-BMI, 0.823, and; TyG-WC, 0.822. The AUCs for TyG-BMI and TyG-WC were significantly higher than those for VAI, LAP, and TyG index (vs. TyG-BMI, p < 0.001; vs. TyG-WC, p < 0.001). The cutoff values were as follows: VAI: men 1.65, women 1.65; LAP: men 42.5, women 42.5; TyG index: men 4.665, women 4.575; TyG-BMI: men 135.5, women 135.5; and TyG-WC: men 461.5, women 440.5. Given that lipid indices can be easily calculated with routine laboratory tests, these values may be useful markers for insulin resistance risk assessments in clinical settings. |
| first_indexed | 2024-12-18T00:20:03Z |
| format | Article |
| id | doaj.art-e93c1e25fd2a4e9bbd371bb541cf9e0d |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-18T00:20:03Z |
| publishDate | 2021-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-e93c1e25fd2a4e9bbd371bb541cf9e0d2022-12-21T21:27:22ZengNature PortfolioScientific Reports2045-23222021-01-011111910.1038/s41598-021-82053-2Lipid indices as simple and clinically useful surrogate markers for insulin resistance in the U.S. populationJuncheol Lee0Bongyoung Kim1Wonhee Kim2Chiwon Ahn3Hyun Young Choi4Jae Guk Kim5Jihoon Kim6Hyungoo Shin7Jun Goo Kang8Shinje Moon9Department of Emergency Medicine, Armed Forces Capital HospitalDepartment of Internal Medicine, Hanyang University College of MedicineDepartment of Emergency Medicine, Hallym UniversityDepartment of Emergency Medicine, College of Medicine, Chung-Ang UniversityDepartment of Emergency Medicine, Hallym UniversityDepartment of Emergency Medicine, Hallym UniversityDepartment of Thoracic and Cardiovascular Surgery, Hallym University College of MedicineDepartment of Emergency Medicine, College of Medicine, Hanyang University Guri HospitalDepartment of Internal Medicine, Hallym UniversityDepartment of Internal Medicine, Hallym UniversityAbstract This study aimed to compare the accuracy of novel lipid indices, including the visceral adiposity index (VAI), lipid accumulation product (LAP), triglycerides and glucose (TyG) index, TyG-body mass index (TyG-BMI), and TyG-waist circumference (TyG-WC), in identifying insulin resistance and establish valid cutoff values. This cross-sectional study used the data of 11,378 adults, derived from the United States National Health and Nutrition Examination Survey (1999–2016). Insulin resistance was defined as a homeostasis model assessment-insulin resistance value above the 75th percentile for each sex and race/ethnicities. The area under the curves (AUCs) were as follows: VAI, 0.735; LAP, 0.796; TyG index, 0.723; TyG-BMI, 0.823, and; TyG-WC, 0.822. The AUCs for TyG-BMI and TyG-WC were significantly higher than those for VAI, LAP, and TyG index (vs. TyG-BMI, p < 0.001; vs. TyG-WC, p < 0.001). The cutoff values were as follows: VAI: men 1.65, women 1.65; LAP: men 42.5, women 42.5; TyG index: men 4.665, women 4.575; TyG-BMI: men 135.5, women 135.5; and TyG-WC: men 461.5, women 440.5. Given that lipid indices can be easily calculated with routine laboratory tests, these values may be useful markers for insulin resistance risk assessments in clinical settings.https://doi.org/10.1038/s41598-021-82053-2 |
| spellingShingle | Juncheol Lee Bongyoung Kim Wonhee Kim Chiwon Ahn Hyun Young Choi Jae Guk Kim Jihoon Kim Hyungoo Shin Jun Goo Kang Shinje Moon Lipid indices as simple and clinically useful surrogate markers for insulin resistance in the U.S. population Scientific Reports |
| title | Lipid indices as simple and clinically useful surrogate markers for insulin resistance in the U.S. population |
| title_full | Lipid indices as simple and clinically useful surrogate markers for insulin resistance in the U.S. population |
| title_fullStr | Lipid indices as simple and clinically useful surrogate markers for insulin resistance in the U.S. population |
| title_full_unstemmed | Lipid indices as simple and clinically useful surrogate markers for insulin resistance in the U.S. population |
| title_short | Lipid indices as simple and clinically useful surrogate markers for insulin resistance in the U.S. population |
| title_sort | lipid indices as simple and clinically useful surrogate markers for insulin resistance in the u s population |
| url | https://doi.org/10.1038/s41598-021-82053-2 |
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