Tumor mineralization-based cancer diagnosis and therapy
Biomineralization is a phenomenon that involves the deposition of inorganic ions onto organic substrates, resulting in the formation of hard tissue materials. Tumor mineralization, on the other hand, encompasses two key aspects: tumor calcification and tumor iron mineralization. The occurrence of sp...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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EDP Sciences
2024-01-01
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| Series: | Visualized Cancer Medicine |
| Subjects: | |
| Online Access: | https://vcm.edpsciences.org/articles/vcm/full_html/2024/01/vcm20230008/vcm20230008.html |
| _version_ | 1797315619997089792 |
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| author | Hu Zhenyu Han Jiahang Li Muzhi Wang Haoyu Shou Hao Wu Jicheng Tang Ning Zhang Qingyan Wang Ben |
| author_facet | Hu Zhenyu Han Jiahang Li Muzhi Wang Haoyu Shou Hao Wu Jicheng Tang Ning Zhang Qingyan Wang Ben |
| author_sort | Hu Zhenyu |
| collection | DOAJ |
| description | Biomineralization is a phenomenon that involves the deposition of inorganic ions onto organic substrates, resulting in the formation of hard tissue materials. Tumor mineralization, on the other hand, encompasses two key aspects: tumor calcification and tumor iron mineralization. The occurrence of spontaneous tumor calcification and regional lymph node calcification in colorectal cancer, lung cancer, and glioblastoma has been established as a favorable prognostic factor in clinical settings. Building upon this understanding, we propose the concept and advance the development of a compound that artificially induces bionic mineralization around the surface of cancer cells. This process has demonstrated exceptional efficacy in inhibiting the growth and metastasis of cervical, breast, and lung tumors. Moreover, it has exhibited outstanding performance in the early-stage diagnosis of cancer. Consequently, we anticipate that this concept holds significant potential for cancer-targeted mineralization therapy and diagnosis, offering a novel avenue for the development of anticancer drugs. |
| first_indexed | 2024-03-08T03:06:26Z |
| format | Article |
| id | doaj.art-e93cb05b24ec4d8fba2fbb2ae7e03e9a |
| institution | Directory Open Access Journal |
| issn | 2740-4218 |
| language | English |
| last_indexed | 2024-03-08T03:06:26Z |
| publishDate | 2024-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | Visualized Cancer Medicine |
| spelling | doaj.art-e93cb05b24ec4d8fba2fbb2ae7e03e9a2024-02-13T08:38:59ZengEDP SciencesVisualized Cancer Medicine2740-42182024-01-015210.1051/vcm/2024001vcm20230008Tumor mineralization-based cancer diagnosis and therapyHu Zhenyu0Han Jiahang1Li Muzhi2Wang Haoyu3Shou Hao4Wu Jicheng5Tang Ning6Zhang Qingyan7Wang Ben8https://orcid.org/0000-0002-4134-1835Zhejiang University School of MedicineZhejiang University School of MedicineZhejiang University School of MedicineZhejiang University School of MedicineCancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), The Second Affiliated Hospital, Zhejiang University School of MedicineCancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), The Second Affiliated Hospital, Zhejiang University School of MedicineCancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), The Second Affiliated Hospital, Zhejiang University School of MedicineCancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), The Second Affiliated Hospital, Zhejiang University School of MedicineCancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), The Second Affiliated Hospital, Zhejiang University School of MedicineBiomineralization is a phenomenon that involves the deposition of inorganic ions onto organic substrates, resulting in the formation of hard tissue materials. Tumor mineralization, on the other hand, encompasses two key aspects: tumor calcification and tumor iron mineralization. The occurrence of spontaneous tumor calcification and regional lymph node calcification in colorectal cancer, lung cancer, and glioblastoma has been established as a favorable prognostic factor in clinical settings. Building upon this understanding, we propose the concept and advance the development of a compound that artificially induces bionic mineralization around the surface of cancer cells. This process has demonstrated exceptional efficacy in inhibiting the growth and metastasis of cervical, breast, and lung tumors. Moreover, it has exhibited outstanding performance in the early-stage diagnosis of cancer. Consequently, we anticipate that this concept holds significant potential for cancer-targeted mineralization therapy and diagnosis, offering a novel avenue for the development of anticancer drugs.https://vcm.edpsciences.org/articles/vcm/full_html/2024/01/vcm20230008/vcm20230008.htmltumor mineralizationtumor calcificationbiomineralizationcancer diagnosiscancer therapy |
| spellingShingle | Hu Zhenyu Han Jiahang Li Muzhi Wang Haoyu Shou Hao Wu Jicheng Tang Ning Zhang Qingyan Wang Ben Tumor mineralization-based cancer diagnosis and therapy Visualized Cancer Medicine tumor mineralization tumor calcification biomineralization cancer diagnosis cancer therapy |
| title | Tumor mineralization-based cancer diagnosis and therapy |
| title_full | Tumor mineralization-based cancer diagnosis and therapy |
| title_fullStr | Tumor mineralization-based cancer diagnosis and therapy |
| title_full_unstemmed | Tumor mineralization-based cancer diagnosis and therapy |
| title_short | Tumor mineralization-based cancer diagnosis and therapy |
| title_sort | tumor mineralization based cancer diagnosis and therapy |
| topic | tumor mineralization tumor calcification biomineralization cancer diagnosis cancer therapy |
| url | https://vcm.edpsciences.org/articles/vcm/full_html/2024/01/vcm20230008/vcm20230008.html |
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