Review Hepatoprotektor Rosela (Hibiscus sabdariffa): Aktivitas, Mekanisme Aksi dan Toksisitas
Liver cirrhosis has become the international health problem that causes significant mortality. Handling using herbs from various countries has been done, one of them by consuming roselle (Hibiscus sabdariffa) calyx extract. H. sabdariffa contains anthocyanins, flavonoids, tannins, and ascorbic acid...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Universitas Tadulako
2017-12-01
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| Series: | Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) |
| Subjects: | |
| Online Access: | http://jurnal.untad.ac.id/jurnal/index.php/Galenika/article/view/8610 |
| _version_ | 1818602021171757056 |
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| author | Steffi Liem Jutti Levita |
| author_facet | Steffi Liem Jutti Levita |
| author_sort | Steffi Liem |
| collection | DOAJ |
| description | Liver cirrhosis has become the international health problem that causes significant mortality. Handling using herbs from various countries has been done, one of them by consuming roselle (Hibiscus sabdariffa) calyx extract. H. sabdariffa contains anthocyanins, flavonoids, tannins, and ascorbic acid that function as hepatoprotector. H. sabdariffacalyx extract may inhibit the increasing of various clinical parameters, such as ALT, AST, ALP, and LDH in various inducer types, ie acetaminophen, CCl4, CdCl2, DNPH, and TAA. The mechanism of action of H. sabdariffacalyx extract are as an antioxidant, inhibition of cytochrome enzyme, induction of phase II metabolism enzymes, increase cell viability percentage, increase CAT, GSH and decrease protein expression of pJNK, tBid and Bax. However, the consumption of H. sabdariffacalyx extract may also cause acute, subchronic, and chronic toxicity depending on the given dose. |
| first_indexed | 2024-12-16T13:00:39Z |
| format | Article |
| id | doaj.art-e93de5750ffc416b8b6e09981111cc55 |
| institution | Directory Open Access Journal |
| issn | 2442-7284 2442-8744 |
| language | English |
| last_indexed | 2024-12-16T13:00:39Z |
| publishDate | 2017-12-01 |
| publisher | Universitas Tadulako |
| record_format | Article |
| series | Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) |
| spelling | doaj.art-e93de5750ffc416b8b6e09981111cc552022-12-21T22:30:51ZengUniversitas TadulakoJurnal Farmasi Galenika (Galenika Journal of Pharmacy)2442-72842442-87442017-12-013210311710.22487/j24428744.0.v0.i0.86107252Review Hepatoprotektor Rosela (Hibiscus sabdariffa): Aktivitas, Mekanisme Aksi dan ToksisitasSteffi Liem0Jutti LevitaUniversitas PadjajaranLiver cirrhosis has become the international health problem that causes significant mortality. Handling using herbs from various countries has been done, one of them by consuming roselle (Hibiscus sabdariffa) calyx extract. H. sabdariffa contains anthocyanins, flavonoids, tannins, and ascorbic acid that function as hepatoprotector. H. sabdariffacalyx extract may inhibit the increasing of various clinical parameters, such as ALT, AST, ALP, and LDH in various inducer types, ie acetaminophen, CCl4, CdCl2, DNPH, and TAA. The mechanism of action of H. sabdariffacalyx extract are as an antioxidant, inhibition of cytochrome enzyme, induction of phase II metabolism enzymes, increase cell viability percentage, increase CAT, GSH and decrease protein expression of pJNK, tBid and Bax. However, the consumption of H. sabdariffacalyx extract may also cause acute, subchronic, and chronic toxicity depending on the given dose.http://jurnal.untad.ac.id/jurnal/index.php/Galenika/article/view/8610Hibiscus sabdariffa, roselle, hepatoprotective, toxicity |
| spellingShingle | Steffi Liem Jutti Levita Review Hepatoprotektor Rosela (Hibiscus sabdariffa): Aktivitas, Mekanisme Aksi dan Toksisitas Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Hibiscus sabdariffa, roselle, hepatoprotective, toxicity |
| title | Review Hepatoprotektor Rosela (Hibiscus sabdariffa): Aktivitas, Mekanisme Aksi dan Toksisitas |
| title_full | Review Hepatoprotektor Rosela (Hibiscus sabdariffa): Aktivitas, Mekanisme Aksi dan Toksisitas |
| title_fullStr | Review Hepatoprotektor Rosela (Hibiscus sabdariffa): Aktivitas, Mekanisme Aksi dan Toksisitas |
| title_full_unstemmed | Review Hepatoprotektor Rosela (Hibiscus sabdariffa): Aktivitas, Mekanisme Aksi dan Toksisitas |
| title_short | Review Hepatoprotektor Rosela (Hibiscus sabdariffa): Aktivitas, Mekanisme Aksi dan Toksisitas |
| title_sort | review hepatoprotektor rosela hibiscus sabdariffa aktivitas mekanisme aksi dan toksisitas |
| topic | Hibiscus sabdariffa, roselle, hepatoprotective, toxicity |
| url | http://jurnal.untad.ac.id/jurnal/index.php/Galenika/article/view/8610 |
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