Novel therapeutic approaches to correct retinal metabolic abnormalities in primary open-angle glaucoma and age-related macular degeneration
Common pathogenic aspects of age-related macular degeneration (AMD) and primary open-angle glaucoma (POAG), i.e., the role of free radicals inducing oxidative damage of the retina and optic nerve, are discussed. Factors that activate free radical reactions as well as multilevel antioxidant protectio...
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| Format: | Article |
| Language: | Russian |
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Ophthalmology Publishing Group
2015-01-01
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| Series: | Oftalʹmologiâ |
| Subjects: | |
| Online Access: | https://www.ophthalmojournal.com/opht/article/view/204 |
| _version_ | 1797875554870886400 |
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| author | K. A. Mirzabekova |
| author_facet | K. A. Mirzabekova |
| author_sort | K. A. Mirzabekova |
| collection | DOAJ |
| description | Common pathogenic aspects of age-related macular degeneration (AMD) and primary open-angle glaucoma (POAG), i.e., the role of free radicals inducing oxidative damage of the retina and optic nerve, are discussed. Factors that activate free radical reactions as well as multilevel antioxidant protection system are reviewed. Data derived from studies on current antioxidants that are used to treat and prevent dry AMD and glaucomatous optic nerve damage are compared. Neuroprotection for glaucoma will be considered soon as a basis for its treatment. B vitamins are generally included into therapeutic algorithms for glaucomatous optic neuropathy. While being metabolic therapeutics, they stimulate adaptive compensatory mechanisms and reduce the severity of various pathological processes, e.g., hypoxia, lipid peroxidation etc. Neurotrophic, antioxidant, and regenerative effects of B vitamins as wells as their involvement in metabolism, myelinsynthesis and other processes are of special importance for ophthalmologists. Currently, several vitamin and mineral supplements that differ in composition, dosage, and schedule are approved in Russia. SuperOptic, a biologically activeadditive, contains more free lutein (10 mg) and zeaxanthin (500 μg) as well as potent antioxidants (vitamin E and vitamin C), microelements (zinc and copper), and balanced vitamin B complex. These components play an important role in ocular health. SuperOptic can be recommended for the prevention and treatment of AMD and glaucomatous optic nerve damage. |
| first_indexed | 2024-04-10T01:49:23Z |
| format | Article |
| id | doaj.art-e93f34550111483d8333f69ea1706d38 |
| institution | Directory Open Access Journal |
| issn | 1816-5095 2500-0845 |
| language | Russian |
| last_indexed | 2024-04-10T01:49:23Z |
| publishDate | 2015-01-01 |
| publisher | Ophthalmology Publishing Group |
| record_format | Article |
| series | Oftalʹmologiâ |
| spelling | doaj.art-e93f34550111483d8333f69ea1706d382023-03-13T09:08:36ZrusOphthalmology Publishing GroupOftalʹmologiâ1816-50952500-08452015-01-01114414610.18008/1816-5095-2014-4-791-804202Novel therapeutic approaches to correct retinal metabolic abnormalities in primary open-angle glaucoma and age-related macular degenerationK. A. Mirzabekova0Федеральное государственное бюджетное учреждение Научно-исследовательский институт глазных болезней РАМН , Россолимо, д.11A,Б, 119021, Москва, Российская ФедерацияCommon pathogenic aspects of age-related macular degeneration (AMD) and primary open-angle glaucoma (POAG), i.e., the role of free radicals inducing oxidative damage of the retina and optic nerve, are discussed. Factors that activate free radical reactions as well as multilevel antioxidant protection system are reviewed. Data derived from studies on current antioxidants that are used to treat and prevent dry AMD and glaucomatous optic nerve damage are compared. Neuroprotection for glaucoma will be considered soon as a basis for its treatment. B vitamins are generally included into therapeutic algorithms for glaucomatous optic neuropathy. While being metabolic therapeutics, they stimulate adaptive compensatory mechanisms and reduce the severity of various pathological processes, e.g., hypoxia, lipid peroxidation etc. Neurotrophic, antioxidant, and regenerative effects of B vitamins as wells as their involvement in metabolism, myelinsynthesis and other processes are of special importance for ophthalmologists. Currently, several vitamin and mineral supplements that differ in composition, dosage, and schedule are approved in Russia. SuperOptic, a biologically activeadditive, contains more free lutein (10 mg) and zeaxanthin (500 μg) as well as potent antioxidants (vitamin E and vitamin C), microelements (zinc and copper), and balanced vitamin B complex. These components play an important role in ocular health. SuperOptic can be recommended for the prevention and treatment of AMD and glaucomatous optic nerve damage.https://www.ophthalmojournal.com/opht/article/view/204вмдантиоксидантылютеинзеаксантинокислительный стрессглаукома |
| spellingShingle | K. A. Mirzabekova Novel therapeutic approaches to correct retinal metabolic abnormalities in primary open-angle glaucoma and age-related macular degeneration Oftalʹmologiâ вмд антиоксиданты лютеин зеаксантин окислительный стресс глаукома |
| title | Novel therapeutic approaches to correct retinal metabolic abnormalities in primary open-angle glaucoma and age-related macular degeneration |
| title_full | Novel therapeutic approaches to correct retinal metabolic abnormalities in primary open-angle glaucoma and age-related macular degeneration |
| title_fullStr | Novel therapeutic approaches to correct retinal metabolic abnormalities in primary open-angle glaucoma and age-related macular degeneration |
| title_full_unstemmed | Novel therapeutic approaches to correct retinal metabolic abnormalities in primary open-angle glaucoma and age-related macular degeneration |
| title_short | Novel therapeutic approaches to correct retinal metabolic abnormalities in primary open-angle glaucoma and age-related macular degeneration |
| title_sort | novel therapeutic approaches to correct retinal metabolic abnormalities in primary open angle glaucoma and age related macular degeneration |
| topic | вмд антиоксиданты лютеин зеаксантин окислительный стресс глаукома |
| url | https://www.ophthalmojournal.com/opht/article/view/204 |
| work_keys_str_mv | AT kamirzabekova noveltherapeuticapproachestocorrectretinalmetabolicabnormalitiesinprimaryopenangleglaucomaandagerelatedmaculardegeneration |