Changes in sensorimotor regions of the cerebral cortex in congenital amusia: a case-control study
Perceiving pitch is a central function of the human auditory system; congenital amusia is a disorder of pitch perception. The underlying neural mechanisms of congenital amusia have been actively discussed. However, little attention has been paid to the changes in the motor rain within congenital amu...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Neural Regeneration Research |
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| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2021;volume=16;issue=3;spage=531;epage=536;aulast=Sun |
| _version_ | 1818553398826369024 |
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| author | Jun-Jie Sun Xue-Qun Pan Ru Yang Zhi-Shuai Jin Yi-Hui Li Jun Liu Da-Xing Wu |
| author_facet | Jun-Jie Sun Xue-Qun Pan Ru Yang Zhi-Shuai Jin Yi-Hui Li Jun Liu Da-Xing Wu |
| author_sort | Jun-Jie Sun |
| collection | DOAJ |
| description | Perceiving pitch is a central function of the human auditory system; congenital amusia is a disorder of pitch perception. The underlying neural mechanisms of congenital amusia have been actively discussed. However, little attention has been paid to the changes in the motor rain within congenital amusia. In this case-control study, 17 participants with congenital amusia and 14 healthy controls underwent functional magnetic resonance imaging while resting with their eyes closed. A voxel-based degree centrality method was used to identify abnormal functional network centrality by comparing degree centrality values between the congenital amusia group and the healthy control group. We found decreased degree centrality values in the right primary sensorimotor areas in participants with congenital amusia relative to controls, indicating potentially decreased centrality of the corresponding brain regions in the auditory-sensory motor feedback network. We found a significant positive correlation between the degree centrality values and the Montreal Battery of Evaluation of Amusia scores. In conclusion, our study identified novel, hitherto undiscussed candidate brain regions that may partly contribute to or be modulated by congenital amusia. Our evidence supports the view that sensorimotor coupling plays an important role in memory and musical discrimination. The study was approved by the Ethics Committee of the Second Xiangya Hospital, Central South University, China (No. WDX20180101GZ01) on February 9, 2019. |
| first_indexed | 2024-12-12T09:25:20Z |
| format | Article |
| id | doaj.art-e940a90cb037447abe5b3d1b363de38d |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-12-12T09:25:20Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-e940a90cb037447abe5b3d1b363de38d2022-12-22T00:29:04ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742021-01-0116353153610.4103/1673-5374.293154Changes in sensorimotor regions of the cerebral cortex in congenital amusia: a case-control studyJun-Jie SunXue-Qun PanRu YangZhi-Shuai JinYi-Hui LiJun LiuDa-Xing WuPerceiving pitch is a central function of the human auditory system; congenital amusia is a disorder of pitch perception. The underlying neural mechanisms of congenital amusia have been actively discussed. However, little attention has been paid to the changes in the motor rain within congenital amusia. In this case-control study, 17 participants with congenital amusia and 14 healthy controls underwent functional magnetic resonance imaging while resting with their eyes closed. A voxel-based degree centrality method was used to identify abnormal functional network centrality by comparing degree centrality values between the congenital amusia group and the healthy control group. We found decreased degree centrality values in the right primary sensorimotor areas in participants with congenital amusia relative to controls, indicating potentially decreased centrality of the corresponding brain regions in the auditory-sensory motor feedback network. We found a significant positive correlation between the degree centrality values and the Montreal Battery of Evaluation of Amusia scores. In conclusion, our study identified novel, hitherto undiscussed candidate brain regions that may partly contribute to or be modulated by congenital amusia. Our evidence supports the view that sensorimotor coupling plays an important role in memory and musical discrimination. The study was approved by the Ethics Committee of the Second Xiangya Hospital, Central South University, China (No. WDX20180101GZ01) on February 9, 2019.http://www.nrronline.org/article.asp?issn=1673-5374;year=2021;volume=16;issue=3;spage=531;epage=536;aulast=Suncongenital amusia; degree centrality; lifelong impairment; local functional connectivity; music discrimination; primary motor area; primary sensorimotor area; primary sensory area; resting-state functional magnetic resonance imaging; voxel-based analysis |
| spellingShingle | Jun-Jie Sun Xue-Qun Pan Ru Yang Zhi-Shuai Jin Yi-Hui Li Jun Liu Da-Xing Wu Changes in sensorimotor regions of the cerebral cortex in congenital amusia: a case-control study Neural Regeneration Research congenital amusia; degree centrality; lifelong impairment; local functional connectivity; music discrimination; primary motor area; primary sensorimotor area; primary sensory area; resting-state functional magnetic resonance imaging; voxel-based analysis |
| title | Changes in sensorimotor regions of the cerebral cortex in congenital amusia: a case-control study |
| title_full | Changes in sensorimotor regions of the cerebral cortex in congenital amusia: a case-control study |
| title_fullStr | Changes in sensorimotor regions of the cerebral cortex in congenital amusia: a case-control study |
| title_full_unstemmed | Changes in sensorimotor regions of the cerebral cortex in congenital amusia: a case-control study |
| title_short | Changes in sensorimotor regions of the cerebral cortex in congenital amusia: a case-control study |
| title_sort | changes in sensorimotor regions of the cerebral cortex in congenital amusia a case control study |
| topic | congenital amusia; degree centrality; lifelong impairment; local functional connectivity; music discrimination; primary motor area; primary sensorimotor area; primary sensory area; resting-state functional magnetic resonance imaging; voxel-based analysis |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2021;volume=16;issue=3;spage=531;epage=536;aulast=Sun |
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