Diisoprenyl Cyclohexene-Type Meroterpenoids with Cytotoxic Activity from a Mangrove Endophytic Fungus <i>Aspergillus</i> sp. GXNU-Y85
Five new diisoprenyl cyclohexene-type meroterpenoids, aspergienynes J–N (<b>1</b>–<b>5</b>), along with three known analogues (<b>6</b>–<b>8</b>), were obtained from the mangrove endophytic fungal strain <i>Aspergillus</i> sp. GXNU-Y85. The...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/22/2/58 |
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| author | Feng Qin Zi-Shuo Song Li Luo Xiang-Long Bo Fu-Rong Wu Mei-Jing Tan Fan-Fan Wang Xi-Shan Huang Heng-Shan Wang |
| author_facet | Feng Qin Zi-Shuo Song Li Luo Xiang-Long Bo Fu-Rong Wu Mei-Jing Tan Fan-Fan Wang Xi-Shan Huang Heng-Shan Wang |
| author_sort | Feng Qin |
| collection | DOAJ |
| description | Five new diisoprenyl cyclohexene-type meroterpenoids, aspergienynes J–N (<b>1</b>–<b>5</b>), along with three known analogues (<b>6</b>–<b>8</b>), were obtained from the mangrove endophytic fungal strain <i>Aspergillus</i> sp. GXNU-Y85. The chemical structures, including their absolute configurations, were established via spectroscopic data and comparison of experimental and calculated ECD spectra. Cytotoxicity assay results indicated that compound <b>8</b> had strong cytotoxicity against HeLa cancer cells, and its IC<sub>50</sub> value was 11.8 μM. In addition, flow cytometry analysis revealed that the cytotoxicity of <b>8</b> was due to the induction of G1 cell cycle arrest and apoptosis in HeLa cells. |
| first_indexed | 2024-03-07T22:24:12Z |
| format | Article |
| id | doaj.art-e942971e9fd94eb3ae5cf9145b391d0b |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-07T22:24:12Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-e942971e9fd94eb3ae5cf9145b391d0b2024-02-23T15:25:12ZengMDPI AGMarine Drugs1660-33972024-01-012225810.3390/md22020058Diisoprenyl Cyclohexene-Type Meroterpenoids with Cytotoxic Activity from a Mangrove Endophytic Fungus <i>Aspergillus</i> sp. GXNU-Y85Feng Qin0Zi-Shuo Song1Li Luo2Xiang-Long Bo3Fu-Rong Wu4Mei-Jing Tan5Fan-Fan Wang6Xi-Shan Huang7Heng-Shan Wang8State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources/Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, ChinaState Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources/Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, ChinaState Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources/Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, ChinaState Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources/Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, ChinaState Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources/Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, ChinaState Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources/Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, ChinaGuangxi Key Laboratory of Agricultural Resources Chemistry and Biotechnology, College of Chemistry and Food Science, Yulin Normal University, Yulin 537000, ChinaState Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources/Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, ChinaState Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources/Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education of China), Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, ChinaFive new diisoprenyl cyclohexene-type meroterpenoids, aspergienynes J–N (<b>1</b>–<b>5</b>), along with three known analogues (<b>6</b>–<b>8</b>), were obtained from the mangrove endophytic fungal strain <i>Aspergillus</i> sp. GXNU-Y85. The chemical structures, including their absolute configurations, were established via spectroscopic data and comparison of experimental and calculated ECD spectra. Cytotoxicity assay results indicated that compound <b>8</b> had strong cytotoxicity against HeLa cancer cells, and its IC<sub>50</sub> value was 11.8 μM. In addition, flow cytometry analysis revealed that the cytotoxicity of <b>8</b> was due to the induction of G1 cell cycle arrest and apoptosis in HeLa cells.https://www.mdpi.com/1660-3397/22/2/58mangrove endophytic fungus<i>Aspergillus</i> sp.meroterpenoidsanti-cancer activity |
| spellingShingle | Feng Qin Zi-Shuo Song Li Luo Xiang-Long Bo Fu-Rong Wu Mei-Jing Tan Fan-Fan Wang Xi-Shan Huang Heng-Shan Wang Diisoprenyl Cyclohexene-Type Meroterpenoids with Cytotoxic Activity from a Mangrove Endophytic Fungus <i>Aspergillus</i> sp. GXNU-Y85 Marine Drugs mangrove endophytic fungus <i>Aspergillus</i> sp. meroterpenoids anti-cancer activity |
| title | Diisoprenyl Cyclohexene-Type Meroterpenoids with Cytotoxic Activity from a Mangrove Endophytic Fungus <i>Aspergillus</i> sp. GXNU-Y85 |
| title_full | Diisoprenyl Cyclohexene-Type Meroterpenoids with Cytotoxic Activity from a Mangrove Endophytic Fungus <i>Aspergillus</i> sp. GXNU-Y85 |
| title_fullStr | Diisoprenyl Cyclohexene-Type Meroterpenoids with Cytotoxic Activity from a Mangrove Endophytic Fungus <i>Aspergillus</i> sp. GXNU-Y85 |
| title_full_unstemmed | Diisoprenyl Cyclohexene-Type Meroterpenoids with Cytotoxic Activity from a Mangrove Endophytic Fungus <i>Aspergillus</i> sp. GXNU-Y85 |
| title_short | Diisoprenyl Cyclohexene-Type Meroterpenoids with Cytotoxic Activity from a Mangrove Endophytic Fungus <i>Aspergillus</i> sp. GXNU-Y85 |
| title_sort | diisoprenyl cyclohexene type meroterpenoids with cytotoxic activity from a mangrove endophytic fungus i aspergillus i sp gxnu y85 |
| topic | mangrove endophytic fungus <i>Aspergillus</i> sp. meroterpenoids anti-cancer activity |
| url | https://www.mdpi.com/1660-3397/22/2/58 |
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