Local Application of Krill Oil Accelerates the Healing of Artificially Created Wounds in Diabetic Mice
Diabetes mellitus (DM) impairs the wound healing process, seriously threatening the health of the diabetic population. To date, few effective approaches have been developed for the treatment of diabetic wounds. Krill oil (KO) contains bioactive components that have potent anti-inflammatory and anti-...
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MDPI AG
2022-10-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/19/4139 |
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| author | Wenhao Hao Huali Meng Hui Li Yan Zheng Chunhong Song Ziping Jiang Xue Bai Zhiyue Zhang Lei Du Pei Liu Hao Wu |
| author_facet | Wenhao Hao Huali Meng Hui Li Yan Zheng Chunhong Song Ziping Jiang Xue Bai Zhiyue Zhang Lei Du Pei Liu Hao Wu |
| author_sort | Wenhao Hao |
| collection | DOAJ |
| description | Diabetes mellitus (DM) impairs the wound healing process, seriously threatening the health of the diabetic population. To date, few effective approaches have been developed for the treatment of diabetic wounds. Krill oil (KO) contains bioactive components that have potent anti-inflammatory and anti-oxidative activities. As prolonged inflammation is a crucial contributor to DM-impaired wound healing, we speculated that the local application of KO would accelerate diabetic wound healing. Therefore, KO was applied to artificially created wounds of type 2 diabetic mice induced by streptozotocin and high-fat diet. The diabetic mice had a delayed wound healing process compared with the non-diabetic control mice, with excessive inflammation, impaired collagen deposition, and depressed neovascularization in the wound area. These effects were dramatically reversed by KO. In vitro, KO blocked the TNF-α-induced macrophage inflammation, fibroblast dysfunction, and endothelial angiogenic impairment. The present study in mice suggests that KO local application could be a viable approach in the management of diabetic wounds. |
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| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T21:19:19Z |
| publishDate | 2022-10-01 |
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| series | Nutrients |
| spelling | doaj.art-e94511d51db74d6bb0f2161824e178062023-11-23T21:26:17ZengMDPI AGNutrients2072-66432022-10-011419413910.3390/nu14194139Local Application of Krill Oil Accelerates the Healing of Artificially Created Wounds in Diabetic MiceWenhao Hao0Huali Meng1Hui Li2Yan Zheng3Chunhong Song4Ziping Jiang5Xue Bai6Zhiyue Zhang7Lei Du8Pei Liu9Hao Wu10Department of Nutrition and Food Hygiene, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, ChinaDepartment of Nutrition and Food Hygiene, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, ChinaNMPA Key Laboratory for Technology Research and Evaluation of Drug Products, Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, ChinaResearch Center of Translational Medicine, Jinan Central Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250013, ChinaDepartment of Laboratory Animal Center, Central Hospital Affiliated to Shandong First Medical University, Jinan 250013, ChinaDepartment of Hand and Foot Surgery, The First Hospital of Jilin University, Changchun 130021, ChinaDepartment of Physical and Chemical Inspection, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, ChinaNMPA Key Laboratory for Technology Research and Evaluation of Drug Products, Key Laboratory of Chemical Biology (Ministry of Education), Department of Pharmaceutics, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan 250012, ChinaDepartment of Nutrition and Food Hygiene, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, ChinaDepartment of Plastic Surgery, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250012, ChinaDepartment of Nutrition and Food Hygiene, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, ChinaDiabetes mellitus (DM) impairs the wound healing process, seriously threatening the health of the diabetic population. To date, few effective approaches have been developed for the treatment of diabetic wounds. Krill oil (KO) contains bioactive components that have potent anti-inflammatory and anti-oxidative activities. As prolonged inflammation is a crucial contributor to DM-impaired wound healing, we speculated that the local application of KO would accelerate diabetic wound healing. Therefore, KO was applied to artificially created wounds of type 2 diabetic mice induced by streptozotocin and high-fat diet. The diabetic mice had a delayed wound healing process compared with the non-diabetic control mice, with excessive inflammation, impaired collagen deposition, and depressed neovascularization in the wound area. These effects were dramatically reversed by KO. In vitro, KO blocked the TNF-α-induced macrophage inflammation, fibroblast dysfunction, and endothelial angiogenic impairment. The present study in mice suggests that KO local application could be a viable approach in the management of diabetic wounds.https://www.mdpi.com/2072-6643/14/19/4139cutaneousdiabeteskrill oilskinwound healing |
| spellingShingle | Wenhao Hao Huali Meng Hui Li Yan Zheng Chunhong Song Ziping Jiang Xue Bai Zhiyue Zhang Lei Du Pei Liu Hao Wu Local Application of Krill Oil Accelerates the Healing of Artificially Created Wounds in Diabetic Mice Nutrients cutaneous diabetes krill oil skin wound healing |
| title | Local Application of Krill Oil Accelerates the Healing of Artificially Created Wounds in Diabetic Mice |
| title_full | Local Application of Krill Oil Accelerates the Healing of Artificially Created Wounds in Diabetic Mice |
| title_fullStr | Local Application of Krill Oil Accelerates the Healing of Artificially Created Wounds in Diabetic Mice |
| title_full_unstemmed | Local Application of Krill Oil Accelerates the Healing of Artificially Created Wounds in Diabetic Mice |
| title_short | Local Application of Krill Oil Accelerates the Healing of Artificially Created Wounds in Diabetic Mice |
| title_sort | local application of krill oil accelerates the healing of artificially created wounds in diabetic mice |
| topic | cutaneous diabetes krill oil skin wound healing |
| url | https://www.mdpi.com/2072-6643/14/19/4139 |
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