Investigation of Suitable Detection Angles for Carbon-Ion Radiotherapy Monitoring in Depth by Means of Secondary-Ion Tracking
The dose conformity of carbon-ion beam radiotherapy, which allows the reduction of the dose deposition in healthy tissue and the escalation of the dose to the tumor, is associated with a high sensitivity to anatomical changes during and between treatment irradiations. Thus, the monitoring of inter-f...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.780221/full |
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| author | Laura Ghesquière-Diérickx Laura Ghesquière-Diérickx Laura Ghesquière-Diérickx Annika Schlechter Annika Schlechter Annika Schlechter Renato Félix-Bautista Renato Félix-Bautista Renato Félix-Bautista Tim Gehrke Tim Gehrke Gernot Echner Gernot Echner Laurent Kelleter Laurent Kelleter Mária Martišíková Mária Martišíková |
| author_facet | Laura Ghesquière-Diérickx Laura Ghesquière-Diérickx Laura Ghesquière-Diérickx Annika Schlechter Annika Schlechter Annika Schlechter Renato Félix-Bautista Renato Félix-Bautista Renato Félix-Bautista Tim Gehrke Tim Gehrke Gernot Echner Gernot Echner Laurent Kelleter Laurent Kelleter Mária Martišíková Mária Martišíková |
| author_sort | Laura Ghesquière-Diérickx |
| collection | DOAJ |
| description | The dose conformity of carbon-ion beam radiotherapy, which allows the reduction of the dose deposition in healthy tissue and the escalation of the dose to the tumor, is associated with a high sensitivity to anatomical changes during and between treatment irradiations. Thus, the monitoring of inter-fractional anatomical changes is crucial to ensure the dose conformity, to potentially reduce the size of the safety margins around the tumor and ultimately to reduce the irradiation of healthy tissue. To do so, monitoring methods of carbon-ion radiotherapy in depth using secondary-ion tracking are being investigated. In this work, the detection and localization of a small air cavity of 2 mm thickness were investigated at different detection angles of the mini-tracker relative to the beam axis. The experiments were conducted with a PMMA head phantom at the Heidelberg Ion-Beam Therapy Center (HIT) in Germany. In a clinic-like irradiation of a single field of 3 Gy (RBE), secondary-ion emission profiles were measured by a 2 cm2 mini-tracker composed of two silicon pixel detectors. Two positions of the cavity in the head phantom were studied: in front and in the middle of the tumor volume. The significance of the cavity detection was found to be increased at smaller detection angles, while the accuracy of the cavity localization was improved at larger detection angles. Detection angles of 20° – 30° were found to be a good compromise for accessing both, the detectability and the position of the air cavity along the depth in the head of a patient. |
| first_indexed | 2024-12-19T05:37:42Z |
| format | Article |
| id | doaj.art-e9455f4ae4a94465abad1e7875eb2805 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-19T05:37:42Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-e9455f4ae4a94465abad1e7875eb28052022-12-21T20:34:06ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-11-011110.3389/fonc.2021.780221780221Investigation of Suitable Detection Angles for Carbon-Ion Radiotherapy Monitoring in Depth by Means of Secondary-Ion TrackingLaura Ghesquière-Diérickx0Laura Ghesquière-Diérickx1Laura Ghesquière-Diérickx2Annika Schlechter3Annika Schlechter4Annika Schlechter5Renato Félix-Bautista6Renato Félix-Bautista7Renato Félix-Bautista8Tim Gehrke9Tim Gehrke10Gernot Echner11Gernot Echner12Laurent Kelleter13Laurent Kelleter14Mária Martišíková15Mária Martišíková16Department of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, GermanyNational Center for Radiation Research in Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, GermanyHeidelberg Medical Faculty, University of Heidelberg, Heidelberg, GermanyDepartment of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, GermanyNational Center for Radiation Research in Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, GermanyFaculty of Physics and Astronomy, Heidelberg University, Heidelberg, GermanyDepartment of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, GermanyNational Center for Radiation Research in Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, GermanyFaculty of Physics and Astronomy, Heidelberg University, Heidelberg, GermanyDepartment of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, GermanyNational Center for Radiation Research in Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, GermanyDepartment of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, GermanyNational Center for Radiation Research in Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, GermanyDepartment of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, GermanyNational Center for Radiation Research in Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, GermanyDepartment of Medical Physics in Radiation Oncology, German Cancer Research Center (DKFZ), Heidelberg, GermanyNational Center for Radiation Research in Oncology (NCRO), Heidelberg Institute for Radiation Oncology (HIRO), Heidelberg, GermanyThe dose conformity of carbon-ion beam radiotherapy, which allows the reduction of the dose deposition in healthy tissue and the escalation of the dose to the tumor, is associated with a high sensitivity to anatomical changes during and between treatment irradiations. Thus, the monitoring of inter-fractional anatomical changes is crucial to ensure the dose conformity, to potentially reduce the size of the safety margins around the tumor and ultimately to reduce the irradiation of healthy tissue. To do so, monitoring methods of carbon-ion radiotherapy in depth using secondary-ion tracking are being investigated. In this work, the detection and localization of a small air cavity of 2 mm thickness were investigated at different detection angles of the mini-tracker relative to the beam axis. The experiments were conducted with a PMMA head phantom at the Heidelberg Ion-Beam Therapy Center (HIT) in Germany. In a clinic-like irradiation of a single field of 3 Gy (RBE), secondary-ion emission profiles were measured by a 2 cm2 mini-tracker composed of two silicon pixel detectors. Two positions of the cavity in the head phantom were studied: in front and in the middle of the tumor volume. The significance of the cavity detection was found to be increased at smaller detection angles, while the accuracy of the cavity localization was improved at larger detection angles. Detection angles of 20° – 30° were found to be a good compromise for accessing both, the detectability and the position of the air cavity along the depth in the head of a patient.https://www.frontiersin.org/articles/10.3389/fonc.2021.780221/fullcarbon-ion radiotherapyin-vivo treatment monitoringinter-fractional anatomical changessecondary-ion trackingbeam fragmentationsilicon pixel detector |
| spellingShingle | Laura Ghesquière-Diérickx Laura Ghesquière-Diérickx Laura Ghesquière-Diérickx Annika Schlechter Annika Schlechter Annika Schlechter Renato Félix-Bautista Renato Félix-Bautista Renato Félix-Bautista Tim Gehrke Tim Gehrke Gernot Echner Gernot Echner Laurent Kelleter Laurent Kelleter Mária Martišíková Mária Martišíková Investigation of Suitable Detection Angles for Carbon-Ion Radiotherapy Monitoring in Depth by Means of Secondary-Ion Tracking Frontiers in Oncology carbon-ion radiotherapy in-vivo treatment monitoring inter-fractional anatomical changes secondary-ion tracking beam fragmentation silicon pixel detector |
| title | Investigation of Suitable Detection Angles for Carbon-Ion Radiotherapy Monitoring in Depth by Means of Secondary-Ion Tracking |
| title_full | Investigation of Suitable Detection Angles for Carbon-Ion Radiotherapy Monitoring in Depth by Means of Secondary-Ion Tracking |
| title_fullStr | Investigation of Suitable Detection Angles for Carbon-Ion Radiotherapy Monitoring in Depth by Means of Secondary-Ion Tracking |
| title_full_unstemmed | Investigation of Suitable Detection Angles for Carbon-Ion Radiotherapy Monitoring in Depth by Means of Secondary-Ion Tracking |
| title_short | Investigation of Suitable Detection Angles for Carbon-Ion Radiotherapy Monitoring in Depth by Means of Secondary-Ion Tracking |
| title_sort | investigation of suitable detection angles for carbon ion radiotherapy monitoring in depth by means of secondary ion tracking |
| topic | carbon-ion radiotherapy in-vivo treatment monitoring inter-fractional anatomical changes secondary-ion tracking beam fragmentation silicon pixel detector |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2021.780221/full |
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