The Impact of Environmental and Genetic Factors on Bone Quality in Monozygotic and Dizygotic Twins
The purpose of the research was to assess the genetic and environmental influences on bone properties. One hundred thirty-two pairs of twins (99/33 monozygotic/dizygotic) underwent anthropometric measurements and phalangeal quantitative ultrasound (DBM Sonic 1200, Igea, Italy) measuring the amplitud...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-09-01
|
| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/10/10/2360 |
| _version_ | 1827651488840679424 |
|---|---|
| author | Elżbieta Tabor Małgorzata Bach Aleksandra Werner Bogna Drozdzowska Wojciech Pluskiewicz |
| author_facet | Elżbieta Tabor Małgorzata Bach Aleksandra Werner Bogna Drozdzowska Wojciech Pluskiewicz |
| author_sort | Elżbieta Tabor |
| collection | DOAJ |
| description | The purpose of the research was to assess the genetic and environmental influences on bone properties. One hundred thirty-two pairs of twins (99/33 monozygotic/dizygotic) underwent anthropometric measurements and phalangeal quantitative ultrasound (DBM Sonic 1200, Igea, Italy) measuring the amplitude speed of sound (AD-SoS, m/s). The mean age was 16.78 ± 12.35 years for monozygotic twins and 14.30 ± 8 years for dizygotic. Interpair and intrapair correlations between twins were calculated. In the groups of monozygotic and dizygotic twins, Ad-SoS correlated significantly with age (r = 0.56–0.73, <i>p</i> < 0.05), weight (r = 0.73–0.78, <i>p</i> < 0.05), and height (r = 0.80–0.81, <i>p</i> < 0.05). The strongest intrapair correlation (r = 0.99–0.998) was noted in monozygotic females for Ad-SoS, weight, and height. There was a statistically significant correlation between the intrapair difference of Ad-SoS and age but only in the groups of monozygotic and dizygotic females (r = 0.281, r<sup>2</sup> = 0.079, and <i>p</i> = 0.028; r = 0.544, r<sup>2</sup> = 0.296, and <i>p</i> = 0.01, respectively). After age adjustment, it was estimated that 28.62% of Ad-SoS in women and 13.2% of Ad-SoS in men was explained by genetic influence, leading to the conclusion that Ad-SoS changed with age, weight, and height. The strongest correlation between pairs of twins was observed in monozygotic twins. The differences in bone values between female twins arose with age, which indicated the role of environmental factors. |
| first_indexed | 2024-03-09T20:40:22Z |
| format | Article |
| id | doaj.art-e94678acba1743e088f62cf1787a5899 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T20:40:22Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-e94678acba1743e088f62cf1787a58992023-11-23T23:01:45ZengMDPI AGBiomedicines2227-90592022-09-011010236010.3390/biomedicines10102360The Impact of Environmental and Genetic Factors on Bone Quality in Monozygotic and Dizygotic TwinsElżbieta Tabor0Małgorzata Bach1Aleksandra Werner2Bogna Drozdzowska3Wojciech Pluskiewicz4Department and Clinic of Internal Diseases, Diabetology, and Nephrology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, PolandDepartment of Applied Informatics, Silesian University of Technology, 44-100 Gliwice, PolandDepartment of Applied Informatics, Silesian University of Technology, 44-100 Gliwice, PolandDepartment of Pathomorphology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, PolandMetabolic Bone Diseases Unit, Department and Clinic of Internal Diseases, Diabetology, and Nephrology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, PolandThe purpose of the research was to assess the genetic and environmental influences on bone properties. One hundred thirty-two pairs of twins (99/33 monozygotic/dizygotic) underwent anthropometric measurements and phalangeal quantitative ultrasound (DBM Sonic 1200, Igea, Italy) measuring the amplitude speed of sound (AD-SoS, m/s). The mean age was 16.78 ± 12.35 years for monozygotic twins and 14.30 ± 8 years for dizygotic. Interpair and intrapair correlations between twins were calculated. In the groups of monozygotic and dizygotic twins, Ad-SoS correlated significantly with age (r = 0.56–0.73, <i>p</i> < 0.05), weight (r = 0.73–0.78, <i>p</i> < 0.05), and height (r = 0.80–0.81, <i>p</i> < 0.05). The strongest intrapair correlation (r = 0.99–0.998) was noted in monozygotic females for Ad-SoS, weight, and height. There was a statistically significant correlation between the intrapair difference of Ad-SoS and age but only in the groups of monozygotic and dizygotic females (r = 0.281, r<sup>2</sup> = 0.079, and <i>p</i> = 0.028; r = 0.544, r<sup>2</sup> = 0.296, and <i>p</i> = 0.01, respectively). After age adjustment, it was estimated that 28.62% of Ad-SoS in women and 13.2% of Ad-SoS in men was explained by genetic influence, leading to the conclusion that Ad-SoS changed with age, weight, and height. The strongest correlation between pairs of twins was observed in monozygotic twins. The differences in bone values between female twins arose with age, which indicated the role of environmental factors.https://www.mdpi.com/2227-9059/10/10/2360twinsmonozygoticdizygoticbonequantitative ultrasound |
| spellingShingle | Elżbieta Tabor Małgorzata Bach Aleksandra Werner Bogna Drozdzowska Wojciech Pluskiewicz The Impact of Environmental and Genetic Factors on Bone Quality in Monozygotic and Dizygotic Twins Biomedicines twins monozygotic dizygotic bone quantitative ultrasound |
| title | The Impact of Environmental and Genetic Factors on Bone Quality in Monozygotic and Dizygotic Twins |
| title_full | The Impact of Environmental and Genetic Factors on Bone Quality in Monozygotic and Dizygotic Twins |
| title_fullStr | The Impact of Environmental and Genetic Factors on Bone Quality in Monozygotic and Dizygotic Twins |
| title_full_unstemmed | The Impact of Environmental and Genetic Factors on Bone Quality in Monozygotic and Dizygotic Twins |
| title_short | The Impact of Environmental and Genetic Factors on Bone Quality in Monozygotic and Dizygotic Twins |
| title_sort | impact of environmental and genetic factors on bone quality in monozygotic and dizygotic twins |
| topic | twins monozygotic dizygotic bone quantitative ultrasound |
| url | https://www.mdpi.com/2227-9059/10/10/2360 |
| work_keys_str_mv | AT elzbietatabor theimpactofenvironmentalandgeneticfactorsonbonequalityinmonozygoticanddizygotictwins AT małgorzatabach theimpactofenvironmentalandgeneticfactorsonbonequalityinmonozygoticanddizygotictwins AT aleksandrawerner theimpactofenvironmentalandgeneticfactorsonbonequalityinmonozygoticanddizygotictwins AT bognadrozdzowska theimpactofenvironmentalandgeneticfactorsonbonequalityinmonozygoticanddizygotictwins AT wojciechpluskiewicz theimpactofenvironmentalandgeneticfactorsonbonequalityinmonozygoticanddizygotictwins AT elzbietatabor impactofenvironmentalandgeneticfactorsonbonequalityinmonozygoticanddizygotictwins AT małgorzatabach impactofenvironmentalandgeneticfactorsonbonequalityinmonozygoticanddizygotictwins AT aleksandrawerner impactofenvironmentalandgeneticfactorsonbonequalityinmonozygoticanddizygotictwins AT bognadrozdzowska impactofenvironmentalandgeneticfactorsonbonequalityinmonozygoticanddizygotictwins AT wojciechpluskiewicz impactofenvironmentalandgeneticfactorsonbonequalityinmonozygoticanddizygotictwins |