Hepatoprotective effects of Moringa oleifera Lam (Moringaceae) leaf extracts in streptozotocin-induced diabetes in rats
Effects of methanolic leaf extracts of Moringa oleifera (MO) on hepatic injury in streptozotocin (STZ)-induced diabetes were investigated.Male Wister rats were divided into 6 groups (n = 7). Animals in group A were orally treated daily with 3.0 ml/kg/body weight (BW) of distilled water, while B, E a...
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| Format: | Article |
| Language: | English |
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Elsevier
2019-06-01
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| Series: | Journal of Functional Foods |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464619301768 |
| _version_ | 1830090972260728832 |
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| author | Willy Tambwe Muzumbukilwa Manimbulu Nlooto Peter Mark Oroma Owira |
| author_facet | Willy Tambwe Muzumbukilwa Manimbulu Nlooto Peter Mark Oroma Owira |
| author_sort | Willy Tambwe Muzumbukilwa |
| collection | DOAJ |
| description | Effects of methanolic leaf extracts of Moringa oleifera (MO) on hepatic injury in streptozotocin (STZ)-induced diabetes were investigated.Male Wister rats were divided into 6 groups (n = 7). Animals in group A were orally treated daily with 3.0 ml/kg/body weight (BW) of distilled water, while B, E and F were similarly treated with 500, 250 and 500 mg/kg/BW of MO, respectively. Groups C-F were rendered diabetic by single intraperitoneal injections of 45 mg/kg/BW of STZ. Additionally, group D was treated with subcutaneous insulin (2.0 U/kg/BW, bid).Diabetic animals exhibited significant weight loss, polydipsia, impaired glucose tolerance, fasting hypoinsulinemia and impaired liver function tests compared to controls. Treatment with MO methanolic leaf extracts significantly improved weight loss, polydipsia, glucose tolerance and also liver function tests in diabetic animals.MO has dose-dependent antidiabetic and hepatoprotective effects. |
| first_indexed | 2024-12-16T17:11:31Z |
| format | Article |
| id | doaj.art-e94699c933b544b2a24f96fb895bc112 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-16T17:11:31Z |
| publishDate | 2019-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-e94699c933b544b2a24f96fb895bc1122022-12-21T22:23:23ZengElsevierJournal of Functional Foods1756-46462019-06-01577582Hepatoprotective effects of Moringa oleifera Lam (Moringaceae) leaf extracts in streptozotocin-induced diabetes in ratsWilly Tambwe Muzumbukilwa0Manimbulu Nlooto1Peter Mark Oroma Owira2Discipline of Pharmaceutical Sciences, School of Health Sciences, Westville Campus, University of KwaZulu-Natal, University Road, Durban 4001, South AfricaDiscipline of Pharmaceutical Sciences, School of Health Sciences, Westville Campus, University of KwaZulu-Natal, University Road, Durban 4001, South AfricaCorresponding author.; Discipline of Pharmaceutical Sciences, School of Health Sciences, Westville Campus, University of KwaZulu-Natal, University Road, Durban 4001, South AfricaEffects of methanolic leaf extracts of Moringa oleifera (MO) on hepatic injury in streptozotocin (STZ)-induced diabetes were investigated.Male Wister rats were divided into 6 groups (n = 7). Animals in group A were orally treated daily with 3.0 ml/kg/body weight (BW) of distilled water, while B, E and F were similarly treated with 500, 250 and 500 mg/kg/BW of MO, respectively. Groups C-F were rendered diabetic by single intraperitoneal injections of 45 mg/kg/BW of STZ. Additionally, group D was treated with subcutaneous insulin (2.0 U/kg/BW, bid).Diabetic animals exhibited significant weight loss, polydipsia, impaired glucose tolerance, fasting hypoinsulinemia and impaired liver function tests compared to controls. Treatment with MO methanolic leaf extracts significantly improved weight loss, polydipsia, glucose tolerance and also liver function tests in diabetic animals.MO has dose-dependent antidiabetic and hepatoprotective effects.http://www.sciencedirect.com/science/article/pii/S1756464619301768Moringa oleiferaDiabetesStreptozotocinLiver |
| spellingShingle | Willy Tambwe Muzumbukilwa Manimbulu Nlooto Peter Mark Oroma Owira Hepatoprotective effects of Moringa oleifera Lam (Moringaceae) leaf extracts in streptozotocin-induced diabetes in rats Journal of Functional Foods Moringa oleifera Diabetes Streptozotocin Liver |
| title | Hepatoprotective effects of Moringa oleifera Lam (Moringaceae) leaf extracts in streptozotocin-induced diabetes in rats |
| title_full | Hepatoprotective effects of Moringa oleifera Lam (Moringaceae) leaf extracts in streptozotocin-induced diabetes in rats |
| title_fullStr | Hepatoprotective effects of Moringa oleifera Lam (Moringaceae) leaf extracts in streptozotocin-induced diabetes in rats |
| title_full_unstemmed | Hepatoprotective effects of Moringa oleifera Lam (Moringaceae) leaf extracts in streptozotocin-induced diabetes in rats |
| title_short | Hepatoprotective effects of Moringa oleifera Lam (Moringaceae) leaf extracts in streptozotocin-induced diabetes in rats |
| title_sort | hepatoprotective effects of moringa oleifera lam moringaceae leaf extracts in streptozotocin induced diabetes in rats |
| topic | Moringa oleifera Diabetes Streptozotocin Liver |
| url | http://www.sciencedirect.com/science/article/pii/S1756464619301768 |
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