What Is a Solitary Keratoacanthoma? A Benign Follicular Neoplasm, Frequently Associated with Squamous Cell Carcinoma
We present histopathological criteria for diagnosing keratoacanthoma (KA). In KA, four histological stages are recognized, which are the early/proliferative stage, well-developed stage, regressing stage and regressed stage. In diagnosing KA, we emphasize that KA consists of the proliferation of enla...
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MDPI AG
2021-10-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/11/10/1848 |
| _version_ | 1797514898680315904 |
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| author | Azusa Ogita Shin-ichi Ansai |
| author_facet | Azusa Ogita Shin-ichi Ansai |
| author_sort | Azusa Ogita |
| collection | DOAJ |
| description | We present histopathological criteria for diagnosing keratoacanthoma (KA). In KA, four histological stages are recognized, which are the early/proliferative stage, well-developed stage, regressing stage and regressed stage. In diagnosing KA, we emphasize that KA consists of the proliferation of enlarged pale pink cells with ground glass-like cytoplasm without nuclear atypia, other than crateriform architecture. KA sometimes exhibits malignant transformation within the lesions. We describe the characteristics of benign and malignant epithelial crateriform tumors that should be differentiated from KA. We also present the data of histopathological diagnosis of lesions clinically diagnosed as KA, its natural course and related lesions after partial biopsy, and incidence of crateriform epithelial neoplasms. Based on these data, we recommend complete excision of the lesion when KA is clinically suspected, especially when the lesion is located on a sun-exposed area of an elderly patient. If complete excision is impossible, partial excision of a sufficient specimen with intact architecture is required. In such a case, however, careful investigation after biopsy will be needed, even if the histopathological diagnosis is KA, because there is some possibility that a conventional SCC lesion remains in the residual tissue. |
| first_indexed | 2024-03-10T06:38:04Z |
| format | Article |
| id | doaj.art-e946a70c3a984e1fa23aa06148e09ccf |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T06:38:04Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-e946a70c3a984e1fa23aa06148e09ccf2023-11-22T17:57:42ZengMDPI AGDiagnostics2075-44182021-10-011110184810.3390/diagnostics11101848What Is a Solitary Keratoacanthoma? A Benign Follicular Neoplasm, Frequently Associated with Squamous Cell CarcinomaAzusa Ogita0Shin-ichi Ansai1Division of Dermatology and Dermatopathology, Nippon Medical School Musashi Kosugi Hospital, Kawasaki 211-8533, JapanDivision of Dermatology and Dermatopathology, Nippon Medical School Musashi Kosugi Hospital, Kawasaki 211-8533, JapanWe present histopathological criteria for diagnosing keratoacanthoma (KA). In KA, four histological stages are recognized, which are the early/proliferative stage, well-developed stage, regressing stage and regressed stage. In diagnosing KA, we emphasize that KA consists of the proliferation of enlarged pale pink cells with ground glass-like cytoplasm without nuclear atypia, other than crateriform architecture. KA sometimes exhibits malignant transformation within the lesions. We describe the characteristics of benign and malignant epithelial crateriform tumors that should be differentiated from KA. We also present the data of histopathological diagnosis of lesions clinically diagnosed as KA, its natural course and related lesions after partial biopsy, and incidence of crateriform epithelial neoplasms. Based on these data, we recommend complete excision of the lesion when KA is clinically suspected, especially when the lesion is located on a sun-exposed area of an elderly patient. If complete excision is impossible, partial excision of a sufficient specimen with intact architecture is required. In such a case, however, careful investigation after biopsy will be needed, even if the histopathological diagnosis is KA, because there is some possibility that a conventional SCC lesion remains in the residual tissue.https://www.mdpi.com/2075-4418/11/10/1848keratoacanthomasquamous cell carcinoma (SCC)keratoacanthoma-like SCCkeratoacanthoma with malignant transformationcrateriform neoplasmscrateriform verruca |
| spellingShingle | Azusa Ogita Shin-ichi Ansai What Is a Solitary Keratoacanthoma? A Benign Follicular Neoplasm, Frequently Associated with Squamous Cell Carcinoma Diagnostics keratoacanthoma squamous cell carcinoma (SCC) keratoacanthoma-like SCC keratoacanthoma with malignant transformation crateriform neoplasms crateriform verruca |
| title | What Is a Solitary Keratoacanthoma? A Benign Follicular Neoplasm, Frequently Associated with Squamous Cell Carcinoma |
| title_full | What Is a Solitary Keratoacanthoma? A Benign Follicular Neoplasm, Frequently Associated with Squamous Cell Carcinoma |
| title_fullStr | What Is a Solitary Keratoacanthoma? A Benign Follicular Neoplasm, Frequently Associated with Squamous Cell Carcinoma |
| title_full_unstemmed | What Is a Solitary Keratoacanthoma? A Benign Follicular Neoplasm, Frequently Associated with Squamous Cell Carcinoma |
| title_short | What Is a Solitary Keratoacanthoma? A Benign Follicular Neoplasm, Frequently Associated with Squamous Cell Carcinoma |
| title_sort | what is a solitary keratoacanthoma a benign follicular neoplasm frequently associated with squamous cell carcinoma |
| topic | keratoacanthoma squamous cell carcinoma (SCC) keratoacanthoma-like SCC keratoacanthoma with malignant transformation crateriform neoplasms crateriform verruca |
| url | https://www.mdpi.com/2075-4418/11/10/1848 |
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