Neuropeptides in Nematodes: Presence, Localization, and Effect on Locomotor Behavior
The investigations of the presence and distribution of neuropeptides in free-living and parasitic nematodes from various systematic groups have begun in the late 1980s. As a result of numerous studies, the family of FMRFamide-like peptides (FLPs) or FMRFamide-relative peptides (FaRPs) has been ident...
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| Format: | Article |
| Language: | English |
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Kazan Federal University
2015-06-01
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| Series: | Učënye Zapiski Kazanskogo Universiteta. Seriâ Estestvennye Nauki |
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| Online Access: | http://kpfu.ru/portal/docs/F2033076467/157_2_est_2_e.pdf |
| _version_ | 1797694632313749504 |
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| author | Malyutina T.A. Terenina N.B. Kreshchenko N.D. |
| author_facet | Malyutina T.A. Terenina N.B. Kreshchenko N.D. |
| author_sort | Malyutina T.A. |
| collection | DOAJ |
| description | The investigations of the presence and distribution of neuropeptides in free-living and parasitic nematodes from various systematic groups have begun in the late 1980s. As a result of numerous studies, the family of FMRFamide-like peptides (FLPs) or FMRFamide-relative peptides (FaRPs) has been identi-fied. FLPs are relatively short peptides (typically < 20 amino acids) ending with a carboxyterminal RFamide motif. FMRFamide-like peptides are one of the largest and most diverse neuropeptide families, which members demonstrate the structural conservatism within all types of animals, including Nemathel-minthes (class Nematoda). It has been shown that many FMRFamide-like neuropeptides in free-living and parasitic species have a high level of structural conservatism, which does not depend on their life cycle, thereby suggesting that FLPs perform important biological functions in nematodes. The literature review is dedicated to analysis of the action of some relatively short FMRFamide-like neuropeptides isolated from free-living and zooparasitic nematodes on the locomotor behavior of the nematode Ascaris suum. Possible application of nematode FLPs or their synthetic structural analogs as anthelminthic drugs is discussed. |
| first_indexed | 2024-03-12T02:59:35Z |
| format | Article |
| id | doaj.art-e947226bf7154cb0813323249977e33f |
| institution | Directory Open Access Journal |
| issn | 1815-6169 2500-218X |
| language | English |
| last_indexed | 2024-03-12T02:59:35Z |
| publishDate | 2015-06-01 |
| publisher | Kazan Federal University |
| record_format | Article |
| series | Učënye Zapiski Kazanskogo Universiteta. Seriâ Estestvennye Nauki |
| spelling | doaj.art-e947226bf7154cb0813323249977e33f2023-09-03T14:55:48ZengKazan Federal UniversityUčënye Zapiski Kazanskogo Universiteta. Seriâ Estestvennye Nauki1815-61692500-218X2015-06-0115723548Neuropeptides in Nematodes: Presence, Localization, and Effect on Locomotor BehaviorMalyutina T.A.0Terenina N.B.1Kreshchenko N.D.2A.N. Severtsov Institute of Ecology and Evolution, Russian Academy of Sciences, Moscow, 119071 RussiaA.N. Severtsov Institute of Ecology and Evolution, Russian Academy of Sciences, Moscow, 119071 RussiaInstitute of Cell Biophysics, Russian Academy of Sciences, Pushchino, 142290 RussiaThe investigations of the presence and distribution of neuropeptides in free-living and parasitic nematodes from various systematic groups have begun in the late 1980s. As a result of numerous studies, the family of FMRFamide-like peptides (FLPs) or FMRFamide-relative peptides (FaRPs) has been identi-fied. FLPs are relatively short peptides (typically < 20 amino acids) ending with a carboxyterminal RFamide motif. FMRFamide-like peptides are one of the largest and most diverse neuropeptide families, which members demonstrate the structural conservatism within all types of animals, including Nemathel-minthes (class Nematoda). It has been shown that many FMRFamide-like neuropeptides in free-living and parasitic species have a high level of structural conservatism, which does not depend on their life cycle, thereby suggesting that FLPs perform important biological functions in nematodes. The literature review is dedicated to analysis of the action of some relatively short FMRFamide-like neuropeptides isolated from free-living and zooparasitic nematodes on the locomotor behavior of the nematode Ascaris suum. Possible application of nematode FLPs or their synthetic structural analogs as anthelminthic drugs is discussed.http://kpfu.ru/portal/docs/F2033076467/157_2_est_2_e.pdfnematodesneuropeptidesFMRFamide-related peptidereceptorslocomotions |
| spellingShingle | Malyutina T.A. Terenina N.B. Kreshchenko N.D. Neuropeptides in Nematodes: Presence, Localization, and Effect on Locomotor Behavior Učënye Zapiski Kazanskogo Universiteta. Seriâ Estestvennye Nauki nematodes neuropeptides FMRFamide-related peptide receptors locomotions |
| title | Neuropeptides in Nematodes: Presence, Localization, and Effect on Locomotor Behavior |
| title_full | Neuropeptides in Nematodes: Presence, Localization, and Effect on Locomotor Behavior |
| title_fullStr | Neuropeptides in Nematodes: Presence, Localization, and Effect on Locomotor Behavior |
| title_full_unstemmed | Neuropeptides in Nematodes: Presence, Localization, and Effect on Locomotor Behavior |
| title_short | Neuropeptides in Nematodes: Presence, Localization, and Effect on Locomotor Behavior |
| title_sort | neuropeptides in nematodes presence localization and effect on locomotor behavior |
| topic | nematodes neuropeptides FMRFamide-related peptide receptors locomotions |
| url | http://kpfu.ru/portal/docs/F2033076467/157_2_est_2_e.pdf |
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