Treatment of major vein injury with the hemostatic fleece TachoSil by interposing a peritoneal patch to avoid vein thrombosis: A feasibility study in pigs
<b>Background</b> : Vein lacerations in awkward locations are difficult to repair and carry high mortality. The hemostatic fleece, TachoSil, is effective in preventing intraoperative bleeding in different settings, but has not been recommended for use in large vein injury. TachoSil with...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2011-01-01
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| Series: | Journal of Emergencies, Trauma and Shock |
| Subjects: | |
| Online Access: | http://www.onlinejets.org/article.asp?issn=0974-2700;year=2011;volume=4;issue=1;spage=77;epage=81;aulast=Dregelid |
| _version_ | 1818581918606688256 |
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| author | Dregelid Einar Pedersen Gustav |
| author_facet | Dregelid Einar Pedersen Gustav |
| author_sort | Dregelid Einar |
| collection | DOAJ |
| description | <b>Background</b> : Vein lacerations in awkward locations are difficult to repair and carry high mortality. The hemostatic fleece, TachoSil, is effective in preventing intraoperative bleeding in different settings, but has not been recommended for use in large vein injury. TachoSil with a peritoneal patch interposed to avoid vein thrombosis has been reported as a method to obtain hemostasis in vein laceration, but further studies of this method are needed. <b>Materials and Methods</b> : A 1.5 × 1 cm defect was created in the vena cava in five pigs. A 26 × 32 mm peritoneal patch was applied on the coagulant side of a 48 × 48 mm TachoSil sheet, and used to cover the defect. Light compression with a wet sponge was applied for 3 min. No vascular suturing was performed. <b>Results</b> : Successful hemostasis was obtained in four out of the five pigs although the minimum TachoSil gluing zone surrounding the peritoneal patch was only 0-2 mm. The fifth pig died of hemorrhage 30 min after surgery due to a 4-mm stretch with no TachoSil gluing zone outside the peritoneal patch. At six days postoperatively the peritoneal patch was well integrated into the vein wall. After 28 days, the peritoneal patch was almost indiscernible from surrounding vein endothelium. <b>Conclusions</b> : Vein wall defects can be repaired using TachoSil with a peritoneal patch interposed to prevent contact between the thrombogenic TachoSil sheet and the vein lumen. An adequate TachoSil gluing zone all around the patch is essential. |
| first_indexed | 2024-12-16T07:41:08Z |
| format | Article |
| id | doaj.art-e9486584f7494b4f90e4fce22ea52a9a |
| institution | Directory Open Access Journal |
| issn | 0974-2700 0974-519X |
| language | English |
| last_indexed | 2024-12-16T07:41:08Z |
| publishDate | 2011-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Emergencies, Trauma and Shock |
| spelling | doaj.art-e9486584f7494b4f90e4fce22ea52a9a2022-12-21T22:39:05ZengWolters Kluwer Medknow PublicationsJournal of Emergencies, Trauma and Shock0974-27000974-519X2011-01-01417781Treatment of major vein injury with the hemostatic fleece TachoSil by interposing a peritoneal patch to avoid vein thrombosis: A feasibility study in pigsDregelid EinarPedersen Gustav<b>Background</b> : Vein lacerations in awkward locations are difficult to repair and carry high mortality. The hemostatic fleece, TachoSil, is effective in preventing intraoperative bleeding in different settings, but has not been recommended for use in large vein injury. TachoSil with a peritoneal patch interposed to avoid vein thrombosis has been reported as a method to obtain hemostasis in vein laceration, but further studies of this method are needed. <b>Materials and Methods</b> : A 1.5 × 1 cm defect was created in the vena cava in five pigs. A 26 × 32 mm peritoneal patch was applied on the coagulant side of a 48 × 48 mm TachoSil sheet, and used to cover the defect. Light compression with a wet sponge was applied for 3 min. No vascular suturing was performed. <b>Results</b> : Successful hemostasis was obtained in four out of the five pigs although the minimum TachoSil gluing zone surrounding the peritoneal patch was only 0-2 mm. The fifth pig died of hemorrhage 30 min after surgery due to a 4-mm stretch with no TachoSil gluing zone outside the peritoneal patch. At six days postoperatively the peritoneal patch was well integrated into the vein wall. After 28 days, the peritoneal patch was almost indiscernible from surrounding vein endothelium. <b>Conclusions</b> : Vein wall defects can be repaired using TachoSil with a peritoneal patch interposed to prevent contact between the thrombogenic TachoSil sheet and the vein lumen. An adequate TachoSil gluing zone all around the patch is essential.http://www.onlinejets.org/article.asp?issn=0974-2700;year=2011;volume=4;issue=1;spage=77;epage=81;aulast=DregelidHemostatic agentTachosilvascular traumavein injuryvein repair |
| spellingShingle | Dregelid Einar Pedersen Gustav Treatment of major vein injury with the hemostatic fleece TachoSil by interposing a peritoneal patch to avoid vein thrombosis: A feasibility study in pigs Journal of Emergencies, Trauma and Shock Hemostatic agent Tachosil vascular trauma vein injury vein repair |
| title | Treatment of major vein injury with the hemostatic fleece TachoSil by interposing a peritoneal patch to avoid vein thrombosis: A feasibility study in pigs |
| title_full | Treatment of major vein injury with the hemostatic fleece TachoSil by interposing a peritoneal patch to avoid vein thrombosis: A feasibility study in pigs |
| title_fullStr | Treatment of major vein injury with the hemostatic fleece TachoSil by interposing a peritoneal patch to avoid vein thrombosis: A feasibility study in pigs |
| title_full_unstemmed | Treatment of major vein injury with the hemostatic fleece TachoSil by interposing a peritoneal patch to avoid vein thrombosis: A feasibility study in pigs |
| title_short | Treatment of major vein injury with the hemostatic fleece TachoSil by interposing a peritoneal patch to avoid vein thrombosis: A feasibility study in pigs |
| title_sort | treatment of major vein injury with the hemostatic fleece tachosil by interposing a peritoneal patch to avoid vein thrombosis a feasibility study in pigs |
| topic | Hemostatic agent Tachosil vascular trauma vein injury vein repair |
| url | http://www.onlinejets.org/article.asp?issn=0974-2700;year=2011;volume=4;issue=1;spage=77;epage=81;aulast=Dregelid |
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