Longitudinal visual functional recovery in compressive optic neuropathy in patients with primary pituitary microadenoma after endoscopic transnasal surgery
Background: Neoplasms of the chiasmal and optic nerve region can result in compressive optic neuropathy with reduced visual acuity (VA), visual field defects and primary descending optic atrophy. Anterior visual pathway compression by the neoplasm is an absolute indication for surgical intervention....
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| Format: | Article |
| Language: | English |
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Ukrainian Society of Ophthalmologists
2021-06-01
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| Series: | Journal of Ophthalmology |
| Subjects: | |
| Online Access: | https://www.ozhurnal.com/en/archive/2021/3/5-fulltext |
| _version_ | 1797654531099590656 |
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| author | K. S. Iegorova M. O. Guk L.D. Pichkur L.V. Zadoianyi V.N. Konakh |
| author_facet | K. S. Iegorova M. O. Guk L.D. Pichkur L.V. Zadoianyi V.N. Konakh |
| author_sort | K. S. Iegorova |
| collection | DOAJ |
| description | Background: Neoplasms of the chiasmal and optic nerve region can result in compressive optic neuropathy with reduced visual acuity (VA), visual field defects and primary descending optic atrophy. Anterior visual pathway compression by the neoplasm is an absolute indication for surgical intervention.
Purpose: To review the phases of visual functional recovery in compressive optic neuropathy in patients with primary pituitary microadenoma after endoscopic transnasal surgery.
Material and Methods: We retrospectively reviewed the records of 225 patients who were treated for pituitary adenoma at the Romodanov Neurosurgery Institute from 2017 through 2019. All patients (450 eyes) had optic nerve/chiasm complex (ONCC) compression, reduced VA and/or visual field defects preoperatively and underwent surgical decompression of the ONCC. The time points for eye examination were day 1 or 2 after hospitalization (time point 0), and day 5, 6 or 7 (early postoperative examination; time point 1), month 1 (time point 2), month 3 (time point 3), month 6 (time point 4), and month 12 (time point 5) after surgery.
Results: In the majority of patients, decompression of the ONCC resulted in an improvement in or recovery of vision. There was a significant difference (p < 0.05) in VA and mean defect (MD) between time point 1 (VA: 0.74 ± 0.02; MD: 7.85 ± 0.29 dB) and time point 3 (VA: 0.8 ± 0.01; MD: 6.37 ± 0.28 dB). Moreover, there was a significant difference in MD between time point 1 (7.85 ± 0.29 dB) and time point 2 (6.91 ± 0.28 dB), and between time point 2 and time point 4 (6.08 ± 0.28 dB).
Conclusion: After surgical decompression of the ONCC, we observed the two phases of visual functional recovery: fast (as long as several days) and delayed (until 6 months). There was practically no further improvement in visual functions after month 6. |
| first_indexed | 2024-03-11T17:00:49Z |
| format | Article |
| id | doaj.art-e94bfe3e13004a1ab3047eb47be76835 |
| institution | Directory Open Access Journal |
| issn | 2412-8740 |
| language | English |
| last_indexed | 2024-03-11T17:00:49Z |
| publishDate | 2021-06-01 |
| publisher | Ukrainian Society of Ophthalmologists |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj.art-e94bfe3e13004a1ab3047eb47be768352023-10-20T10:35:06ZengUkrainian Society of OphthalmologistsJournal of Ophthalmology2412-87402021-06-013283310.31288/oftalmolzh202132833Longitudinal visual functional recovery in compressive optic neuropathy in patients with primary pituitary microadenoma after endoscopic transnasal surgery K. S. Iegorova0M. O. Guk1L.D. Pichkur 2L.V. Zadoianyi3V.N. Konakh4SI «Romodanov Neurosurgery Institute of the National Academy of Medical Sciences of Ukraine»SI «Romodanov Neurosurgery Institute of the National Academy of Medical Sciences of Ukraine»SI «Romodanov Neurosurgery Institute of the National Academy of Medical Sciences of Ukraine»SI «Romodanov Neurosurgery Institute of the National Academy of Medical Sciences of Ukraine»Bogomolets National Medical UniversityBackground: Neoplasms of the chiasmal and optic nerve region can result in compressive optic neuropathy with reduced visual acuity (VA), visual field defects and primary descending optic atrophy. Anterior visual pathway compression by the neoplasm is an absolute indication for surgical intervention. Purpose: To review the phases of visual functional recovery in compressive optic neuropathy in patients with primary pituitary microadenoma after endoscopic transnasal surgery. Material and Methods: We retrospectively reviewed the records of 225 patients who were treated for pituitary adenoma at the Romodanov Neurosurgery Institute from 2017 through 2019. All patients (450 eyes) had optic nerve/chiasm complex (ONCC) compression, reduced VA and/or visual field defects preoperatively and underwent surgical decompression of the ONCC. The time points for eye examination were day 1 or 2 after hospitalization (time point 0), and day 5, 6 or 7 (early postoperative examination; time point 1), month 1 (time point 2), month 3 (time point 3), month 6 (time point 4), and month 12 (time point 5) after surgery. Results: In the majority of patients, decompression of the ONCC resulted in an improvement in or recovery of vision. There was a significant difference (p < 0.05) in VA and mean defect (MD) between time point 1 (VA: 0.74 ± 0.02; MD: 7.85 ± 0.29 dB) and time point 3 (VA: 0.8 ± 0.01; MD: 6.37 ± 0.28 dB). Moreover, there was a significant difference in MD between time point 1 (7.85 ± 0.29 dB) and time point 2 (6.91 ± 0.28 dB), and between time point 2 and time point 4 (6.08 ± 0.28 dB). Conclusion: After surgical decompression of the ONCC, we observed the two phases of visual functional recovery: fast (as long as several days) and delayed (until 6 months). There was practically no further improvement in visual functions after month 6.https://www.ozhurnal.com/en/archive/2021/3/5-fulltextskull-base tumorspituitary asenomachiasmal syndromecompressive optic atrophyphases of visual functional recoveryendoscopic transnasal surgery |
| spellingShingle | K. S. Iegorova M. O. Guk L.D. Pichkur L.V. Zadoianyi V.N. Konakh Longitudinal visual functional recovery in compressive optic neuropathy in patients with primary pituitary microadenoma after endoscopic transnasal surgery Journal of Ophthalmology skull-base tumors pituitary asenoma chiasmal syndrome compressive optic atrophy phases of visual functional recovery endoscopic transnasal surgery |
| title | Longitudinal visual functional recovery in compressive optic neuropathy in patients with primary pituitary microadenoma after endoscopic transnasal surgery |
| title_full | Longitudinal visual functional recovery in compressive optic neuropathy in patients with primary pituitary microadenoma after endoscopic transnasal surgery |
| title_fullStr | Longitudinal visual functional recovery in compressive optic neuropathy in patients with primary pituitary microadenoma after endoscopic transnasal surgery |
| title_full_unstemmed | Longitudinal visual functional recovery in compressive optic neuropathy in patients with primary pituitary microadenoma after endoscopic transnasal surgery |
| title_short | Longitudinal visual functional recovery in compressive optic neuropathy in patients with primary pituitary microadenoma after endoscopic transnasal surgery |
| title_sort | longitudinal visual functional recovery in compressive optic neuropathy in patients with primary pituitary microadenoma after endoscopic transnasal surgery |
| topic | skull-base tumors pituitary asenoma chiasmal syndrome compressive optic atrophy phases of visual functional recovery endoscopic transnasal surgery |
| url | https://www.ozhurnal.com/en/archive/2021/3/5-fulltext |
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