Taking a Breather: Advances in Interleukin 5 Inhibition for Asthma Relief
Interleukin 5 (IL-5) is a major cytokine responsible for eosinophil proliferation, migration and degranulation. Eosinophils play a considerable role in the manifestation of type 2 asthma, and therefore this makes IL-5 a unique and clinically important target for therapeutic intervention. Due to the...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/19/11166 |
| _version_ | 1797479172092723200 |
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| author | Oliver William Massey Cenk Suphioglu |
| author_facet | Oliver William Massey Cenk Suphioglu |
| author_sort | Oliver William Massey |
| collection | DOAJ |
| description | Interleukin 5 (IL-5) is a major cytokine responsible for eosinophil proliferation, migration and degranulation. Eosinophils play a considerable role in the manifestation of type 2 asthma, and therefore this makes IL-5 a unique and clinically important target for therapeutic intervention. Due to the critical role that IL-5 plays in all areas of eosinophil activity, it has been identified and targeted by three therapeutics, Mepolizumab, Benralizumab and Reslizumab. This review describes the IL-5 pathway and presents the clinical trial history of the three IL-5 inhibitors, to provide insight into the role of IL-5 in clinical asthma presentation. Additionally, this review aims to foster further investigation into the IL-5 pathway by describing current novel therapeutic discovery strategies with monoclonal antibodies. |
| first_indexed | 2024-03-09T21:42:38Z |
| format | Article |
| id | doaj.art-e94c369b92684eb5a69865cc578a94cc |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T21:42:38Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-e94c369b92684eb5a69865cc578a94cc2023-11-23T20:28:29ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-09-0123191116610.3390/ijms231911166Taking a Breather: Advances in Interleukin 5 Inhibition for Asthma ReliefOliver William Massey0Cenk Suphioglu1NeuroAllergy Research Laboratory (NARL), School of Life and Environmental Sciences, Faculty of Science, Engineering and Built Environment, Deakin University, 75 Pigdons Road, Geelong, VIC 3216, AustraliaNeuroAllergy Research Laboratory (NARL), School of Life and Environmental Sciences, Faculty of Science, Engineering and Built Environment, Deakin University, 75 Pigdons Road, Geelong, VIC 3216, AustraliaInterleukin 5 (IL-5) is a major cytokine responsible for eosinophil proliferation, migration and degranulation. Eosinophils play a considerable role in the manifestation of type 2 asthma, and therefore this makes IL-5 a unique and clinically important target for therapeutic intervention. Due to the critical role that IL-5 plays in all areas of eosinophil activity, it has been identified and targeted by three therapeutics, Mepolizumab, Benralizumab and Reslizumab. This review describes the IL-5 pathway and presents the clinical trial history of the three IL-5 inhibitors, to provide insight into the role of IL-5 in clinical asthma presentation. Additionally, this review aims to foster further investigation into the IL-5 pathway by describing current novel therapeutic discovery strategies with monoclonal antibodies.https://www.mdpi.com/1422-0067/23/19/11166Interleukin-5asthmaMepolizumabBenralizumabReslizumabeosinophilic inflammation |
| spellingShingle | Oliver William Massey Cenk Suphioglu Taking a Breather: Advances in Interleukin 5 Inhibition for Asthma Relief International Journal of Molecular Sciences Interleukin-5 asthma Mepolizumab Benralizumab Reslizumab eosinophilic inflammation |
| title | Taking a Breather: Advances in Interleukin 5 Inhibition for Asthma Relief |
| title_full | Taking a Breather: Advances in Interleukin 5 Inhibition for Asthma Relief |
| title_fullStr | Taking a Breather: Advances in Interleukin 5 Inhibition for Asthma Relief |
| title_full_unstemmed | Taking a Breather: Advances in Interleukin 5 Inhibition for Asthma Relief |
| title_short | Taking a Breather: Advances in Interleukin 5 Inhibition for Asthma Relief |
| title_sort | taking a breather advances in interleukin 5 inhibition for asthma relief |
| topic | Interleukin-5 asthma Mepolizumab Benralizumab Reslizumab eosinophilic inflammation |
| url | https://www.mdpi.com/1422-0067/23/19/11166 |
| work_keys_str_mv | AT oliverwilliammassey takingabreatheradvancesininterleukin5inhibitionforasthmarelief AT cenksuphioglu takingabreatheradvancesininterleukin5inhibitionforasthmarelief |