Chrysin ameliorates synovitis and fibrosis of osteoarthritic fibroblast-like synoviocytes in rats through PERK/TXNIP/NLRP3 signaling

Chrysin ameliorates synovitis and fibrosis of osteoarthritic fibroblast-like synoviocytes in rats through PERK/TXNIP/NLRP3 signaling

Objective: Synovitis and fibrosis are common pathological features of knee osteoarthritis (KOA). The interaction of synovitis and fibrosis can promote KOA progression. Chrysin (CHR), a natural flavonoid, may treat inflammation and prevent fibrosis. However, the effect and mechanism of CHR in KOA syn...

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Bibliographic Details
Main Authors: Liang Ding, Taiyang Liao, Nan Yang, Yibao Wei, Runlin Xing, Peng Wu, Xiaochen Li, Jun Mao, Peimin Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Pharmacology
Subjects:
knee osteoarthritis
chrysin
synovitis
fibrosis
PERK/TXNIP/NLRP3
synovial fibroblasts
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1170243/full

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