In situ antigen modification-based target-redirected universal chimeric antigen receptor T (TRUE CAR-T) cell therapy in solid tumors

In situ antigen modification-based target-redirected universal chimeric antigen receptor T (TRUE CAR-T) cell therapy in solid tumors

Abstract Background Chimeric antigen receptor (CAR)-T cell therapy has demonstrated remarkable success in the treatment of hematologic malignancies, while the success has not yet been replicated in solid tumors. To some extent, the disappointing results can be attributed to the paucity and heterogen...

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Bibliographic Details
Main Authors: Zhichen Sun, Rutian Li, Yun Shen, Siyi Tan, Naiqing Ding, Ruihan Xu, Xinyue Wang, Jia Wei, Baorui Liu, Fanyan Meng
Format: Article
Language:English
Published: BMC 2022-03-01
Series:Journal of Hematology & Oncology
Subjects:
Fusogenic nanoparticles
Antigen modification
Universal CAR-T cells
Cancer mmunotherapies
Solid tumors
Online Access:https://doi.org/10.1186/s13045-022-01246-y

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