Butyric acid bacteria culture solution improves hyperglycemia in alloxan-induced diabetes mellitus rats
Butyric acid bacteria (BAB) are the primary intestinal flora present in all mammalian digestive tracts. Prior studies have found the association between decreased intestinal BAB population and development of diabetes, and BAB was suggested as a new treatment of type 2 diabetes. However, few studies...
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| Format: | Article |
| Language: | English |
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Kafkas University, Faculty of Veterinary Medicine
2021-09-01
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| Series: | Kafkas Universitesi Veteriner Fakültesi Dergisi |
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| Online Access: | https://vetdergikafkas.org/pdf.php?id=2838 |
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| author | Kazumi SHIMADA Sakiko HARA Seijirow GOYA Ahmed S. MANDOUR Pitipat KITPIPATKUN Lina HAMABE Akiko UEMURA Joe TAKIZAWA Ryou TANAKA |
| author_facet | Kazumi SHIMADA Sakiko HARA Seijirow GOYA Ahmed S. MANDOUR Pitipat KITPIPATKUN Lina HAMABE Akiko UEMURA Joe TAKIZAWA Ryou TANAKA |
| author_sort | Kazumi SHIMADA |
| collection | DOAJ |
| description | Butyric acid bacteria (BAB) are the primary intestinal flora present in all mammalian digestive tracts. Prior studies have found the association between decreased intestinal BAB population and development of diabetes, and BAB was suggested as a new treatment of type 2 diabetes. However, few studies have examined the effect of BAB on type 1 diabetes (DM1), which is frequently diagnosed in pet animals. Therefore, the aim of this study was to examine the therapeutic effects of BAB culture solution in the DM1 model. Thirty female rats were included for induction of DM1 by alloxan (200 mg/kg, IP). After one week, DM1 was developed in 13 rats (blood glucose level >300 mg/dL) which were then treated with BAB culture solution at a dose rate of 300 μL/kg/day for two weeks. The result revealed a reduction in blood glucose level (P<0.05) and improvement of polydipsia and polyuria in six diabetic rats; meanwhile, 7 rats did not respond to the treatment. The blood pressure showed no change. In conclusion, the administration of BAB culture solution alleviates symptoms of DM1 by improving glycemic control in the model. The effectiveness of BAB as an alternative or supportive therapy for the treatment of DM1 needs further studies on pet animals. |
| first_indexed | 2024-03-13T04:39:50Z |
| format | Article |
| id | doaj.art-e951498994a64bb6bdd932bccbd21cc8 |
| institution | Directory Open Access Journal |
| issn | 1309-2251 |
| language | English |
| last_indexed | 2024-03-13T04:39:50Z |
| publishDate | 2021-09-01 |
| publisher | Kafkas University, Faculty of Veterinary Medicine |
| record_format | Article |
| series | Kafkas Universitesi Veteriner Fakültesi Dergisi |
| spelling | doaj.art-e951498994a64bb6bdd932bccbd21cc82023-06-19T06:29:11ZengKafkas University, Faculty of Veterinary MedicineKafkas Universitesi Veteriner Fakültesi Dergisi1309-22512021-09-0127556757310.9775/kvfd.2021.258672838Butyric acid bacteria culture solution improves hyperglycemia in alloxan-induced diabetes mellitus ratsKazumi SHIMADA0Sakiko HARA1Seijirow GOYA2Ahmed S. MANDOUR3Pitipat KITPIPATKUN4Lina HAMABE5Akiko UEMURA6Joe TAKIZAWA7Ryou TANAKA8Laboratory of Veterinary Surgery, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, JAPANLaboratory of Veterinary Surgery, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, JAPANLaboratory of Veterinary Surgery, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, JAPANLaboratory of Veterinary Surgery, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, JAPANLaboratory of Veterinary Surgery, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, JAPANLaboratory of Veterinary Surgery, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, JAPANLaboratory of Veterinary Surgery, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, JAPANACE BIO PRODUCT CO., LTD, Tokyo, JAPANLaboratory of Veterinary Surgery, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, JAPANButyric acid bacteria (BAB) are the primary intestinal flora present in all mammalian digestive tracts. Prior studies have found the association between decreased intestinal BAB population and development of diabetes, and BAB was suggested as a new treatment of type 2 diabetes. However, few studies have examined the effect of BAB on type 1 diabetes (DM1), which is frequently diagnosed in pet animals. Therefore, the aim of this study was to examine the therapeutic effects of BAB culture solution in the DM1 model. Thirty female rats were included for induction of DM1 by alloxan (200 mg/kg, IP). After one week, DM1 was developed in 13 rats (blood glucose level >300 mg/dL) which were then treated with BAB culture solution at a dose rate of 300 μL/kg/day for two weeks. The result revealed a reduction in blood glucose level (P<0.05) and improvement of polydipsia and polyuria in six diabetic rats; meanwhile, 7 rats did not respond to the treatment. The blood pressure showed no change. In conclusion, the administration of BAB culture solution alleviates symptoms of DM1 by improving glycemic control in the model. The effectiveness of BAB as an alternative or supportive therapy for the treatment of DM1 needs further studies on pet animals.https://vetdergikafkas.org/pdf.php?id=2838alloxanbutyric acid bacteriahyperglycemiarat diabetes model |
| spellingShingle | Kazumi SHIMADA Sakiko HARA Seijirow GOYA Ahmed S. MANDOUR Pitipat KITPIPATKUN Lina HAMABE Akiko UEMURA Joe TAKIZAWA Ryou TANAKA Butyric acid bacteria culture solution improves hyperglycemia in alloxan-induced diabetes mellitus rats Kafkas Universitesi Veteriner Fakültesi Dergisi alloxan butyric acid bacteria hyperglycemia rat diabetes model |
| title | Butyric acid bacteria culture solution improves hyperglycemia in alloxan-induced diabetes mellitus rats |
| title_full | Butyric acid bacteria culture solution improves hyperglycemia in alloxan-induced diabetes mellitus rats |
| title_fullStr | Butyric acid bacteria culture solution improves hyperglycemia in alloxan-induced diabetes mellitus rats |
| title_full_unstemmed | Butyric acid bacteria culture solution improves hyperglycemia in alloxan-induced diabetes mellitus rats |
| title_short | Butyric acid bacteria culture solution improves hyperglycemia in alloxan-induced diabetes mellitus rats |
| title_sort | butyric acid bacteria culture solution improves hyperglycemia in alloxan induced diabetes mellitus rats |
| topic | alloxan butyric acid bacteria hyperglycemia rat diabetes model |
| url | https://vetdergikafkas.org/pdf.php?id=2838 |
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