The Analysis of Apoptosis in Ameloblastoma: Evaluation of Bcl-2, Bcl-X, Bax, Bak
The apoptotic behavior of ameloblastomas was studied using antibodies against the apoptosis related proteins, Bcl-2, Bcl-X, Bax and Bak. Most of the outer layer cells were predominantly stained by the antimodulating proteins, Bax and Bak. Among the Bcl-2 family, Bcl-2 was the most ubiquitously expre...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Faculty of Dentistry, Universitas Indonesia
2015-08-01
|
| Series: | Journal of Dentistry Indonesia |
| Online Access: | http://jdentistry.ui.ac.id/index.php/JDI/article/view/648 |
| _version_ | 1811338433990230016 |
|---|---|
| author | Ferry Sandra Norifumi Naksmura Hiroshi Takeuchi Takeshi Misuyasu Yuji Shiratsuchi Masamichi Ohishi |
| author_facet | Ferry Sandra Norifumi Naksmura Hiroshi Takeuchi Takeshi Misuyasu Yuji Shiratsuchi Masamichi Ohishi |
| author_sort | Ferry Sandra |
| collection | DOAJ |
| description | The apoptotic behavior of ameloblastomas was studied using antibodies against the apoptosis related proteins, Bcl-2, Bcl-X, Bax and Bak. Most of the outer layer cells were predominantly stained by the antimodulating proteins, Bax and Bak. Among the Bcl-2 family, Bcl-2 was the most ubiquitously expressed protein in ameloblastomas, while Bcl-X was expressed in the greatest concentrations. The acanthomatous areas overexpressed the apoptosis modulating proteins, especially Bak. The outer layer, whose cells had higher apoptotic inhibitor activity than inner layer cells, is suggested to be an active part. |
| first_indexed | 2024-04-13T18:10:42Z |
| format | Article |
| id | doaj.art-e951581fa5ef4006be2e5fbbfe31c8c9 |
| institution | Directory Open Access Journal |
| issn | 1693-9697 2355-4800 |
| language | English |
| last_indexed | 2024-04-13T18:10:42Z |
| publishDate | 2015-08-01 |
| publisher | Faculty of Dentistry, Universitas Indonesia |
| record_format | Article |
| series | Journal of Dentistry Indonesia |
| spelling | doaj.art-e951581fa5ef4006be2e5fbbfe31c8c92022-12-22T02:35:54ZengFaculty of Dentistry, Universitas IndonesiaJournal of Dentistry Indonesia1693-96972355-48002015-08-017248348510.14693/jdi.v20i3.648545The Analysis of Apoptosis in Ameloblastoma: Evaluation of Bcl-2, Bcl-X, Bax, BakFerry Sandra0Norifumi Naksmura1Hiroshi Takeuchi2Takeshi Misuyasu3Yuji Shiratsuchi4Masamichi Ohishi5Department of Oral and Maxillofacial Surgery, Station for Collaborative Research, Faculty of Dentistry, Kyushu University, FukuokaDepartment of Oral and Maxillofacial Surgery, Station for Collaborative Research, Faculty of Dentistry, Kyushu University, FukuokaDepartment of Oral Biochemistry, Station for Collaborative Research, Faculty of Dentistry, Kyushu University, FukuokaDepartment of Oral Biochemistry, Station for Collaborative Research, Faculty of Dentistry, Kyushu University, FukuokaDepartment of Oral and Maxillofacial Surgery, Station for Collaborative Research, Faculty of Dentistry, Kyushu University, FukuokaDepartment of Oral and Maxillofacial Surgery, Station for Collaborative Research, Faculty of Dentistry, Kyushu University, FukuokaThe apoptotic behavior of ameloblastomas was studied using antibodies against the apoptosis related proteins, Bcl-2, Bcl-X, Bax and Bak. Most of the outer layer cells were predominantly stained by the antimodulating proteins, Bax and Bak. Among the Bcl-2 family, Bcl-2 was the most ubiquitously expressed protein in ameloblastomas, while Bcl-X was expressed in the greatest concentrations. The acanthomatous areas overexpressed the apoptosis modulating proteins, especially Bak. The outer layer, whose cells had higher apoptotic inhibitor activity than inner layer cells, is suggested to be an active part.http://jdentistry.ui.ac.id/index.php/JDI/article/view/648 |
| spellingShingle | Ferry Sandra Norifumi Naksmura Hiroshi Takeuchi Takeshi Misuyasu Yuji Shiratsuchi Masamichi Ohishi The Analysis of Apoptosis in Ameloblastoma: Evaluation of Bcl-2, Bcl-X, Bax, Bak Journal of Dentistry Indonesia |
| title | The Analysis of Apoptosis in Ameloblastoma: Evaluation of Bcl-2, Bcl-X, Bax, Bak |
| title_full | The Analysis of Apoptosis in Ameloblastoma: Evaluation of Bcl-2, Bcl-X, Bax, Bak |
| title_fullStr | The Analysis of Apoptosis in Ameloblastoma: Evaluation of Bcl-2, Bcl-X, Bax, Bak |
| title_full_unstemmed | The Analysis of Apoptosis in Ameloblastoma: Evaluation of Bcl-2, Bcl-X, Bax, Bak |
| title_short | The Analysis of Apoptosis in Ameloblastoma: Evaluation of Bcl-2, Bcl-X, Bax, Bak |
| title_sort | analysis of apoptosis in ameloblastoma evaluation of bcl 2 bcl x bax bak |
| url | http://jdentistry.ui.ac.id/index.php/JDI/article/view/648 |
| work_keys_str_mv | AT ferrysandra theanalysisofapoptosisinameloblastomaevaluationofbcl2bclxbaxbak AT norifuminaksmura theanalysisofapoptosisinameloblastomaevaluationofbcl2bclxbaxbak AT hiroshitakeuchi theanalysisofapoptosisinameloblastomaevaluationofbcl2bclxbaxbak AT takeshimisuyasu theanalysisofapoptosisinameloblastomaevaluationofbcl2bclxbaxbak AT yujishiratsuchi theanalysisofapoptosisinameloblastomaevaluationofbcl2bclxbaxbak AT masamichiohishi theanalysisofapoptosisinameloblastomaevaluationofbcl2bclxbaxbak AT ferrysandra analysisofapoptosisinameloblastomaevaluationofbcl2bclxbaxbak AT norifuminaksmura analysisofapoptosisinameloblastomaevaluationofbcl2bclxbaxbak AT hiroshitakeuchi analysisofapoptosisinameloblastomaevaluationofbcl2bclxbaxbak AT takeshimisuyasu analysisofapoptosisinameloblastomaevaluationofbcl2bclxbaxbak AT yujishiratsuchi analysisofapoptosisinameloblastomaevaluationofbcl2bclxbaxbak AT masamichiohishi analysisofapoptosisinameloblastomaevaluationofbcl2bclxbaxbak |