Robust Beam Selection Based on Water Equivalent Thickness Analysis in Passive Scattering Carbon-Ion Radiotherapy for Pancreatic Cancer
Carbon-ion radiotherapy (CIRT) is one of the most effective radiotherapeutic modalities. This study aimed to select robust-beam configurations (BC) by water equivalent thickness (WET) analysis in passive CIRT for pancreatic cancer. The study analyzed 110 computed tomography (CT) images and 600 dose...
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MDPI AG
2023-04-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/9/2520 |
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| author | Yuan Zhou Makoto Sakai Yang Li Yoshiki Kubota Masahiko Okamoto Shintaro Shiba Shohei Okazaki Toshiaki Matsui Tatsuya Ohno |
| author_facet | Yuan Zhou Makoto Sakai Yang Li Yoshiki Kubota Masahiko Okamoto Shintaro Shiba Shohei Okazaki Toshiaki Matsui Tatsuya Ohno |
| author_sort | Yuan Zhou |
| collection | DOAJ |
| description | Carbon-ion radiotherapy (CIRT) is one of the most effective radiotherapeutic modalities. This study aimed to select robust-beam configurations (BC) by water equivalent thickness (WET) analysis in passive CIRT for pancreatic cancer. The study analyzed 110 computed tomography (CT) images and 600 dose distributions of eight patients with pancreatic cancer. The robustness in the beam range was evaluated using both planning and daily CT images, and two robust BCs for the rotating gantry and fixed port were selected. The planned, daily, and accumulated doses were calculated and compared after bone matching (BM) and tumor matching (TM). The dose-volume parameters for the target and organs at risk (OARs) were evaluated. Posterior oblique beams (120–240°) in the supine position and anteroposterior beams (0° and 180°) in the prone position were the most robust to WET changes. The mean CTV V95% reductions with TM were −3.8% and −5.2% with the BC for gantry and the BC for fixed ports, respectively. Despite ensuring robustness, the dose to the OARs increased slightly with WET-based BCs but remained below the dose constraint. The robustness of dose distribution can be improved by BCs that are robust to ΔWET. Robust BC with TM improves the accuracy of passive CIRT for pancreatic cancer. |
| first_indexed | 2024-03-11T04:22:42Z |
| format | Article |
| id | doaj.art-e951a354d7954848ab0e1de724d6359b |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T04:22:42Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-e951a354d7954848ab0e1de724d6359b2023-11-17T22:40:51ZengMDPI AGCancers2072-66942023-04-01159252010.3390/cancers15092520Robust Beam Selection Based on Water Equivalent Thickness Analysis in Passive Scattering Carbon-Ion Radiotherapy for Pancreatic CancerYuan Zhou0Makoto Sakai1Yang Li2Yoshiki Kubota3Masahiko Okamoto4Shintaro Shiba5Shohei Okazaki6Toshiaki Matsui7Tatsuya Ohno8Graduate School of Medicine, Gunma University, Maebashi 371-8511, JapanGunma University Heavy Ion Medical Center, Maebashi 371-8511, JapanGunma University Heavy Ion Medical Center, Maebashi 371-8511, JapanGunma University Heavy Ion Medical Center, Maebashi 371-8511, JapanGraduate School of Medicine, Gunma University, Maebashi 371-8511, JapanGraduate School of Medicine, Gunma University, Maebashi 371-8511, JapanGraduate School of Medicine, Gunma University, Maebashi 371-8511, JapanGraduate School of Medicine, Gunma University, Maebashi 371-8511, JapanGraduate School of Medicine, Gunma University, Maebashi 371-8511, JapanCarbon-ion radiotherapy (CIRT) is one of the most effective radiotherapeutic modalities. This study aimed to select robust-beam configurations (BC) by water equivalent thickness (WET) analysis in passive CIRT for pancreatic cancer. The study analyzed 110 computed tomography (CT) images and 600 dose distributions of eight patients with pancreatic cancer. The robustness in the beam range was evaluated using both planning and daily CT images, and two robust BCs for the rotating gantry and fixed port were selected. The planned, daily, and accumulated doses were calculated and compared after bone matching (BM) and tumor matching (TM). The dose-volume parameters for the target and organs at risk (OARs) were evaluated. Posterior oblique beams (120–240°) in the supine position and anteroposterior beams (0° and 180°) in the prone position were the most robust to WET changes. The mean CTV V95% reductions with TM were −3.8% and −5.2% with the BC for gantry and the BC for fixed ports, respectively. Despite ensuring robustness, the dose to the OARs increased slightly with WET-based BCs but remained below the dose constraint. The robustness of dose distribution can be improved by BCs that are robust to ΔWET. Robust BC with TM improves the accuracy of passive CIRT for pancreatic cancer.https://www.mdpi.com/2072-6694/15/9/2520water equivalent thicknesspancreatic cancerrobust beam configurationcarbon-ion radiotherapyaccumulated dose distributionangular dependency |
| spellingShingle | Yuan Zhou Makoto Sakai Yang Li Yoshiki Kubota Masahiko Okamoto Shintaro Shiba Shohei Okazaki Toshiaki Matsui Tatsuya Ohno Robust Beam Selection Based on Water Equivalent Thickness Analysis in Passive Scattering Carbon-Ion Radiotherapy for Pancreatic Cancer Cancers water equivalent thickness pancreatic cancer robust beam configuration carbon-ion radiotherapy accumulated dose distribution angular dependency |
| title | Robust Beam Selection Based on Water Equivalent Thickness Analysis in Passive Scattering Carbon-Ion Radiotherapy for Pancreatic Cancer |
| title_full | Robust Beam Selection Based on Water Equivalent Thickness Analysis in Passive Scattering Carbon-Ion Radiotherapy for Pancreatic Cancer |
| title_fullStr | Robust Beam Selection Based on Water Equivalent Thickness Analysis in Passive Scattering Carbon-Ion Radiotherapy for Pancreatic Cancer |
| title_full_unstemmed | Robust Beam Selection Based on Water Equivalent Thickness Analysis in Passive Scattering Carbon-Ion Radiotherapy for Pancreatic Cancer |
| title_short | Robust Beam Selection Based on Water Equivalent Thickness Analysis in Passive Scattering Carbon-Ion Radiotherapy for Pancreatic Cancer |
| title_sort | robust beam selection based on water equivalent thickness analysis in passive scattering carbon ion radiotherapy for pancreatic cancer |
| topic | water equivalent thickness pancreatic cancer robust beam configuration carbon-ion radiotherapy accumulated dose distribution angular dependency |
| url | https://www.mdpi.com/2072-6694/15/9/2520 |
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