Novel Development of Nanoparticles—A Promising Direction for Precise Tumor Management
Although the clinical application of nanoparticles is still limited by biological barriers and distribution, with the deepening of our understanding of nanoparticles over the past decades, people are gradually breaking through the previous limitations in the diagnosis and treatment of tumors, provid...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Pharmaceutics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4923/15/1/24 |
| _version_ | 1797437877294989312 |
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| author | Dengke Zhang Qingqing Tang Juan Chen Yanghui Wei Jiawei Chen |
| author_facet | Dengke Zhang Qingqing Tang Juan Chen Yanghui Wei Jiawei Chen |
| author_sort | Dengke Zhang |
| collection | DOAJ |
| description | Although the clinical application of nanoparticles is still limited by biological barriers and distribution, with the deepening of our understanding of nanoparticles over the past decades, people are gradually breaking through the previous limitations in the diagnosis and treatment of tumors, providing novel strategies for clinical decision makers. The transition of nanoparticles from passive targeting to active tumor-targeting by abundant surface-modified nanoparticles is also a development process of precision cancer treatment. Different particles can be used as targeted delivery tools of antitumor drugs. The mechanism of gold nanoparticles inducing apoptosis and cycle arrest of tumor cells has been discovered. Moreover, the unique photothermal effect of gold nanoparticles may be widely used in tumor therapy in the future, with less side effects on surrounding tissues. Lipid-based nanoparticles are expected to overcome the blood–brain barrier due to their special characteristics, while polymer-based nanoparticles show better biocompatibility and lower toxicity. In this paper, we discuss the development of nanoparticles in tumor therapy and the challenges that need to be addressed. |
| first_indexed | 2024-03-09T11:28:58Z |
| format | Article |
| id | doaj.art-e952ab2e20c7491587987398dd0e13f3 |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T11:28:58Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-e952ab2e20c7491587987398dd0e13f32023-11-30T23:56:37ZengMDPI AGPharmaceutics1999-49232022-12-011512410.3390/pharmaceutics15010024Novel Development of Nanoparticles—A Promising Direction for Precise Tumor ManagementDengke Zhang0Qingqing Tang1Juan Chen2Yanghui Wei3Jiawei Chen4Department of Surgery, The Eighth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510275, ChinaDepartment of Surgery, The Eighth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510275, ChinaDepartment of Medicine & Rehabilitation, Tung Wah Eastern Hospital, Hong Kong, ChinaDepartment of Surgery, The Eighth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510275, ChinaDepartment of Surgery, The Eighth Affiliated Hospital, Sun Yat-sen University, Guangzhou 510275, ChinaAlthough the clinical application of nanoparticles is still limited by biological barriers and distribution, with the deepening of our understanding of nanoparticles over the past decades, people are gradually breaking through the previous limitations in the diagnosis and treatment of tumors, providing novel strategies for clinical decision makers. The transition of nanoparticles from passive targeting to active tumor-targeting by abundant surface-modified nanoparticles is also a development process of precision cancer treatment. Different particles can be used as targeted delivery tools of antitumor drugs. The mechanism of gold nanoparticles inducing apoptosis and cycle arrest of tumor cells has been discovered. Moreover, the unique photothermal effect of gold nanoparticles may be widely used in tumor therapy in the future, with less side effects on surrounding tissues. Lipid-based nanoparticles are expected to overcome the blood–brain barrier due to their special characteristics, while polymer-based nanoparticles show better biocompatibility and lower toxicity. In this paper, we discuss the development of nanoparticles in tumor therapy and the challenges that need to be addressed.https://www.mdpi.com/1999-4923/15/1/24nanoparticlestumor-targetingantitumor drug |
| spellingShingle | Dengke Zhang Qingqing Tang Juan Chen Yanghui Wei Jiawei Chen Novel Development of Nanoparticles—A Promising Direction for Precise Tumor Management Pharmaceutics nanoparticles tumor-targeting antitumor drug |
| title | Novel Development of Nanoparticles—A Promising Direction for Precise Tumor Management |
| title_full | Novel Development of Nanoparticles—A Promising Direction for Precise Tumor Management |
| title_fullStr | Novel Development of Nanoparticles—A Promising Direction for Precise Tumor Management |
| title_full_unstemmed | Novel Development of Nanoparticles—A Promising Direction for Precise Tumor Management |
| title_short | Novel Development of Nanoparticles—A Promising Direction for Precise Tumor Management |
| title_sort | novel development of nanoparticles a promising direction for precise tumor management |
| topic | nanoparticles tumor-targeting antitumor drug |
| url | https://www.mdpi.com/1999-4923/15/1/24 |
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