Slik and the receptor tyrosine kinase Breathless mediate localized activation of Moesin in terminal tracheal cells.
A key element in the regulation of subcellular branching and tube morphogenesis of the Drosophila tracheal system is the organization of the actin cytoskeleton by the ERM protein Moesin. Activation of Moesin within specific subdomains of cells, critical for its interaction with actin, is a tightly c...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4111555?pdf=render |
| _version_ | 1818449655523966976 |
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| author | Fiona Paul Ukken Imola Aprill N JayaNandanan Maria Leptin |
| author_facet | Fiona Paul Ukken Imola Aprill N JayaNandanan Maria Leptin |
| author_sort | Fiona Paul Ukken |
| collection | DOAJ |
| description | A key element in the regulation of subcellular branching and tube morphogenesis of the Drosophila tracheal system is the organization of the actin cytoskeleton by the ERM protein Moesin. Activation of Moesin within specific subdomains of cells, critical for its interaction with actin, is a tightly controlled process and involves regulatory inputs from membrane proteins, kinases and phosphatases. The kinases that activate Moesin in tracheal cells are not known. Here we show that the Sterile-20 like kinase Slik, enriched at the luminal membrane, is necessary for the activation of Moesin at the luminal membrane and regulates branching and subcellular tube morphogenesis of terminal cells. Our results reveal the FGF-receptor Breathless as an additional necessary cue for the activation of Moesin in terminal cells. Breathless-mediated activation of Moesin is independent of the canonical MAP kinase pathway. |
| first_indexed | 2024-12-14T20:38:52Z |
| format | Article |
| id | doaj.art-e9552185f4404ed3aa202f666ef0cde7 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-14T20:38:52Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-e9552185f4404ed3aa202f666ef0cde72022-12-21T22:48:20ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0197e10332310.1371/journal.pone.0103323Slik and the receptor tyrosine kinase Breathless mediate localized activation of Moesin in terminal tracheal cells.Fiona Paul UkkenImola AprillN JayaNandananMaria LeptinA key element in the regulation of subcellular branching and tube morphogenesis of the Drosophila tracheal system is the organization of the actin cytoskeleton by the ERM protein Moesin. Activation of Moesin within specific subdomains of cells, critical for its interaction with actin, is a tightly controlled process and involves regulatory inputs from membrane proteins, kinases and phosphatases. The kinases that activate Moesin in tracheal cells are not known. Here we show that the Sterile-20 like kinase Slik, enriched at the luminal membrane, is necessary for the activation of Moesin at the luminal membrane and regulates branching and subcellular tube morphogenesis of terminal cells. Our results reveal the FGF-receptor Breathless as an additional necessary cue for the activation of Moesin in terminal cells. Breathless-mediated activation of Moesin is independent of the canonical MAP kinase pathway.http://europepmc.org/articles/PMC4111555?pdf=render |
| spellingShingle | Fiona Paul Ukken Imola Aprill N JayaNandanan Maria Leptin Slik and the receptor tyrosine kinase Breathless mediate localized activation of Moesin in terminal tracheal cells. PLoS ONE |
| title | Slik and the receptor tyrosine kinase Breathless mediate localized activation of Moesin in terminal tracheal cells. |
| title_full | Slik and the receptor tyrosine kinase Breathless mediate localized activation of Moesin in terminal tracheal cells. |
| title_fullStr | Slik and the receptor tyrosine kinase Breathless mediate localized activation of Moesin in terminal tracheal cells. |
| title_full_unstemmed | Slik and the receptor tyrosine kinase Breathless mediate localized activation of Moesin in terminal tracheal cells. |
| title_short | Slik and the receptor tyrosine kinase Breathless mediate localized activation of Moesin in terminal tracheal cells. |
| title_sort | slik and the receptor tyrosine kinase breathless mediate localized activation of moesin in terminal tracheal cells |
| url | http://europepmc.org/articles/PMC4111555?pdf=render |
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