Association between Vascular Endothelial Markers and Carotid Intima-Media Thickness in Children and Adolescents with Type 1 Diabetes Mellitus
Introduction: Type 1 Diabetes Mellitus (T1DM) is one of the important risk factor for cardiovascular disease. Endothelial dysfunction and increased Carotid Intima-Media Thickness (CIMT) result in cardiovascular complications. Vascular Cell Adhesion Molecule-1 (VCAM-1) and Intercellular Adhesion...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
JCDR Research and Publications Private Limited
2017-09-01
|
Series: | Journal of Clinical and Diagnostic Research |
Subjects: | |
Online Access: | https://jcdr.net/articles/PDF/10541/26623_CE(RA1)_F(T)_PF1_[NE_VT_AP]_PFA(MJ_AP).pdf |
Summary: | Introduction: Type 1 Diabetes Mellitus (T1DM) is one of the
important risk factor for cardiovascular disease. Endothelial
dysfunction and increased Carotid Intima-Media Thickness
(CIMT) result in cardiovascular complications. Vascular Cell
Adhesion Molecule-1 (VCAM-1) and Intercellular Adhesion
Molecule-1 (ICAM-1) are two adhesion molecules that are
markers of early atherosclerosis and play a significant role in
developing atherosclerosis.
Aim: To evaluate CIMT and its association with the levels of
ICAM-1 and VCAM-1 in children and adolescents with T1DM.
Materials and Methods: In this descriptive, cross-sectional
study conducted between April 2013 and September 2014, 29
children aged 7-20 years with T1DM for at least two years and
29 age and sex-matched, healthy individuals were evaluated.
Plasma level of ICAM-1 and VCAM-1 was measured by ELISA,
and CIMT via Doppler ultrasound was also assessed. The data
were analysed by t-test and Pearson’s correlation coefficient in
SPSS 16.0 (p≤0.05).
Results: Independent t-test indicated that there is a significant
difference in ICAM-1 level between the patients and controls
(p<0.001). Further, CIMT was significantly higher in diabetic
subject (p<0.001). CIMT was not significantly associated with
the level of VCAM-1 and ICAM-1 in the patients (p>0.5).
Conclusion: ICAM-1 and VCAM-1 were not associated with
CIMT but, CIMT and level of ICAM-1 were significantly, higher
in diabetic patients, and therefore could be used as useful
tools for identification of early atherosclerosis in children and
adolescents with T1DM. |
---|---|
ISSN: | 2249-782X 0973-709X |