A NIR‐II Photoactivatable “ROS Bomb” with High‐Density Cu2O‐Supported MoS2 Nanoflowers for Anticancer Therapy
Abstract The fast conversion of hydrogen peroxide (H2O2) into reactive oxygen species (ROS) at tumor sites is a promising anticancer strategy by manipulating nanomedicines with near‐infrared light in the second region (NIR‐II). However, this strategy is greatly compromised by the powerful antioxidan...
| Main Authors: | , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-08-01
|
| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202302208 |
| _version_ | 1797736241154752512 |
|---|---|
| author | Jia Huang Guiming Deng Shuya Wang Tianjiao Zhao Qiaohui Chen Yuqi Yang Yongqi Yang Jinping Zhang Yayun Nan Zhaoqian Liu Ke Cao Qiong Huang Kelong Ai |
| author_facet | Jia Huang Guiming Deng Shuya Wang Tianjiao Zhao Qiaohui Chen Yuqi Yang Yongqi Yang Jinping Zhang Yayun Nan Zhaoqian Liu Ke Cao Qiong Huang Kelong Ai |
| author_sort | Jia Huang |
| collection | DOAJ |
| description | Abstract The fast conversion of hydrogen peroxide (H2O2) into reactive oxygen species (ROS) at tumor sites is a promising anticancer strategy by manipulating nanomedicines with near‐infrared light in the second region (NIR‐II). However, this strategy is greatly compromised by the powerful antioxidant capacity of tumors and the limited ROS generation rate of nanomedicines. This dilemma mainly stems from the lack of an effective synthesis method to support high‐density copper‐based nanocatalysts on the surface of photothermal nanomaterials. Herein, a multifunctional nanoplatform (MCPQZ) with high–density cuprous (Cu2O) supported molybdenum disulfide (MoS2) nanoflowers (MC NFs) is developed for the efficient killing of tumors via a potent ROS storm by an innovative method. Under NIR‐II light irradiation, the ROS intensity and maximum reaction velocity (Vmax) produced by MC NFs are 21.6 and 33.8 times that of the non–irradiation group in vitro, which is much higher than most current nanomedicines. Moreover, the strong ROS storm in cancer cells is efficiently formed by MCPQZ (increased by 27.8 times compared to the control), thanks to the fact that MCPQZ effectively pre–weakens the multiple antioxidant systems of cancer cells. This work provides a novel insight to solve the bottleneck of ROS‐based cancer therapy. |
| first_indexed | 2024-03-12T13:10:47Z |
| format | Article |
| id | doaj.art-e957a803208c458f936b79e46c76c709 |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-03-12T13:10:47Z |
| publishDate | 2023-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-e957a803208c458f936b79e46c76c7092023-08-28T03:36:35ZengWileyAdvanced Science2198-38442023-08-011024n/an/a10.1002/advs.202302208A NIR‐II Photoactivatable “ROS Bomb” with High‐Density Cu2O‐Supported MoS2 Nanoflowers for Anticancer TherapyJia Huang0Guiming Deng1Shuya Wang2Tianjiao Zhao3Qiaohui Chen4Yuqi Yang5Yongqi Yang6Jinping Zhang7Yayun Nan8Zhaoqian Liu9Ke Cao10Qiong Huang11Kelong Ai12Department of Pharmacy Xiangya Hospital Central South University Changsha 410008 ChinaDepartment of infection and liver disease The First Hospital of Hunan University of Chinese Medicine Changsha 410007 ChinaDepartment of Pharmacology, Xiangya School of Pharmaceutical Sciences Central South University Changsha 410078 ChinaDepartment of Pharmacology, Xiangya School of Pharmaceutical Sciences Central South University Changsha 410078 ChinaDepartment of Pharmacology, Xiangya School of Pharmaceutical Sciences Central South University Changsha 410078 ChinaDepartment of Pharmacy Xiangya Hospital Central South University Changsha 410008 ChinaDepartment of Pharmacology, Xiangya School of Pharmaceutical Sciences Central South University Changsha 410078 ChinaDepartment of Pharmacy Xiangya Hospital Central South University Changsha 410008 ChinaGeriatric Medical Center People's Hospital of Ningxia Hui Autonomous Region Yinchuan Ningxia 750002 ChinaDepartment of Pharmacology, Xiangya School of Pharmaceutical Sciences Central South University Changsha 410078 ChinaDepartment of Oncology The Third Xiangya Hospital of Central South University Changsha 410013 ChinaDepartment of Pharmacy Xiangya Hospital Central South University Changsha 410008 ChinaDepartment of Pharmacology, Xiangya School of Pharmaceutical Sciences Central South University Changsha 410078 ChinaAbstract The fast conversion of hydrogen peroxide (H2O2) into reactive oxygen species (ROS) at tumor sites is a promising anticancer strategy by manipulating nanomedicines with near‐infrared light in the second region (NIR‐II). However, this strategy is greatly compromised by the powerful antioxidant capacity of tumors and the limited ROS generation rate of nanomedicines. This dilemma mainly stems from the lack of an effective synthesis method to support high‐density copper‐based nanocatalysts on the surface of photothermal nanomaterials. Herein, a multifunctional nanoplatform (MCPQZ) with high–density cuprous (Cu2O) supported molybdenum disulfide (MoS2) nanoflowers (MC NFs) is developed for the efficient killing of tumors via a potent ROS storm by an innovative method. Under NIR‐II light irradiation, the ROS intensity and maximum reaction velocity (Vmax) produced by MC NFs are 21.6 and 33.8 times that of the non–irradiation group in vitro, which is much higher than most current nanomedicines. Moreover, the strong ROS storm in cancer cells is efficiently formed by MCPQZ (increased by 27.8 times compared to the control), thanks to the fact that MCPQZ effectively pre–weakens the multiple antioxidant systems of cancer cells. This work provides a novel insight to solve the bottleneck of ROS‐based cancer therapy.https://doi.org/10.1002/advs.202302208chemodynamic therapycuprous oxidemolybdenum disulfidephotothermal therapysynergistic therapy |
| spellingShingle | Jia Huang Guiming Deng Shuya Wang Tianjiao Zhao Qiaohui Chen Yuqi Yang Yongqi Yang Jinping Zhang Yayun Nan Zhaoqian Liu Ke Cao Qiong Huang Kelong Ai A NIR‐II Photoactivatable “ROS Bomb” with High‐Density Cu2O‐Supported MoS2 Nanoflowers for Anticancer Therapy Advanced Science chemodynamic therapy cuprous oxide molybdenum disulfide photothermal therapy synergistic therapy |
| title | A NIR‐II Photoactivatable “ROS Bomb” with High‐Density Cu2O‐Supported MoS2 Nanoflowers for Anticancer Therapy |
| title_full | A NIR‐II Photoactivatable “ROS Bomb” with High‐Density Cu2O‐Supported MoS2 Nanoflowers for Anticancer Therapy |
| title_fullStr | A NIR‐II Photoactivatable “ROS Bomb” with High‐Density Cu2O‐Supported MoS2 Nanoflowers for Anticancer Therapy |
| title_full_unstemmed | A NIR‐II Photoactivatable “ROS Bomb” with High‐Density Cu2O‐Supported MoS2 Nanoflowers for Anticancer Therapy |
| title_short | A NIR‐II Photoactivatable “ROS Bomb” with High‐Density Cu2O‐Supported MoS2 Nanoflowers for Anticancer Therapy |
| title_sort | nir ii photoactivatable ros bomb with high density cu2o supported mos2 nanoflowers for anticancer therapy |
| topic | chemodynamic therapy cuprous oxide molybdenum disulfide photothermal therapy synergistic therapy |
| url | https://doi.org/10.1002/advs.202302208 |
| work_keys_str_mv | AT jiahuang aniriiphotoactivatablerosbombwithhighdensitycu2osupportedmos2nanoflowersforanticancertherapy AT guimingdeng aniriiphotoactivatablerosbombwithhighdensitycu2osupportedmos2nanoflowersforanticancertherapy AT shuyawang aniriiphotoactivatablerosbombwithhighdensitycu2osupportedmos2nanoflowersforanticancertherapy AT tianjiaozhao aniriiphotoactivatablerosbombwithhighdensitycu2osupportedmos2nanoflowersforanticancertherapy AT qiaohuichen aniriiphotoactivatablerosbombwithhighdensitycu2osupportedmos2nanoflowersforanticancertherapy AT yuqiyang aniriiphotoactivatablerosbombwithhighdensitycu2osupportedmos2nanoflowersforanticancertherapy AT yongqiyang aniriiphotoactivatablerosbombwithhighdensitycu2osupportedmos2nanoflowersforanticancertherapy AT jinpingzhang aniriiphotoactivatablerosbombwithhighdensitycu2osupportedmos2nanoflowersforanticancertherapy AT yayunnan aniriiphotoactivatablerosbombwithhighdensitycu2osupportedmos2nanoflowersforanticancertherapy AT zhaoqianliu aniriiphotoactivatablerosbombwithhighdensitycu2osupportedmos2nanoflowersforanticancertherapy AT kecao aniriiphotoactivatablerosbombwithhighdensitycu2osupportedmos2nanoflowersforanticancertherapy AT qionghuang aniriiphotoactivatablerosbombwithhighdensitycu2osupportedmos2nanoflowersforanticancertherapy AT kelongai aniriiphotoactivatablerosbombwithhighdensitycu2osupportedmos2nanoflowersforanticancertherapy AT jiahuang niriiphotoactivatablerosbombwithhighdensitycu2osupportedmos2nanoflowersforanticancertherapy AT guimingdeng niriiphotoactivatablerosbombwithhighdensitycu2osupportedmos2nanoflowersforanticancertherapy AT shuyawang niriiphotoactivatablerosbombwithhighdensitycu2osupportedmos2nanoflowersforanticancertherapy AT tianjiaozhao niriiphotoactivatablerosbombwithhighdensitycu2osupportedmos2nanoflowersforanticancertherapy AT qiaohuichen niriiphotoactivatablerosbombwithhighdensitycu2osupportedmos2nanoflowersforanticancertherapy AT yuqiyang niriiphotoactivatablerosbombwithhighdensitycu2osupportedmos2nanoflowersforanticancertherapy AT yongqiyang niriiphotoactivatablerosbombwithhighdensitycu2osupportedmos2nanoflowersforanticancertherapy AT jinpingzhang niriiphotoactivatablerosbombwithhighdensitycu2osupportedmos2nanoflowersforanticancertherapy AT yayunnan niriiphotoactivatablerosbombwithhighdensitycu2osupportedmos2nanoflowersforanticancertherapy AT zhaoqianliu niriiphotoactivatablerosbombwithhighdensitycu2osupportedmos2nanoflowersforanticancertherapy AT kecao niriiphotoactivatablerosbombwithhighdensitycu2osupportedmos2nanoflowersforanticancertherapy AT qionghuang niriiphotoactivatablerosbombwithhighdensitycu2osupportedmos2nanoflowersforanticancertherapy AT kelongai niriiphotoactivatablerosbombwithhighdensitycu2osupportedmos2nanoflowersforanticancertherapy |